Author(s): Wajid Ahmad, Rihan Jawed

Email(s): Email ID Not Available

DOI: 10.52711/0975-4377.2022.00022   

Address: Wajid Ahmad*, Rihan Jawed
Department of Pharmaceutics, Institute of Pharmacy, Ankara, Turkey.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2022


ABSTRACT:
The present study aimed to develop an immediate release of Zolmitriptan hydrochloride oral jellies for the treatment of severe migraine. The jellies were prepared by using chitosan hydrochloride with different concentration as a polymer and propylene glycol as a co-polymer. The prepared jellies were evaluated for its various physio-chemical parameters such as pH, appearance, viscosity, in vitro drug release and drug content. The pH of the prepared formulations was found to be in the range of 7.5-8.1. The appearance of the prepared formulations was transparent to opaque. The viscosity of the prepared jellies was found to be in the range of 273600 - 542335 CPS. The drug content of the prepared jellies was found to be more than 97%. The in vitro drug release immediate release with increased concentration of Chitosan Hydrochloride, and the drug release were found to be more than 60% in 15 minutes. This present studies concluded that Zolmitriptan hydrochloride oral jellies can be a better alternative for oral dispersible tablets and it could produce improved bioavailability as compared to other fast releasing dosage form. From the above studies of various parameters, it was concluded that the FJ5 formulation was found to be optimized formulation.


Cite this article:
Wajid Ahmad, Rihan Jawed. Formulation and Evaluation of Chewable Oral Jelly containing Zolmitriptan hydrochloride. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):139-4. doi: 10.52711/0975-4377.2022.00022

Cite(Electronic):
Wajid Ahmad, Rihan Jawed. Formulation and Evaluation of Chewable Oral Jelly containing Zolmitriptan hydrochloride. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):139-4. doi: 10.52711/0975-4377.2022.00022   Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-2-7


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