Author(s): Wajid Ahmad, Rihan Jawed

Email(s): Email ID Not Available

DOI: 10.52711/0975-4377.2022.00022   

Address: Wajid Ahmad*, Rihan Jawed
Department of Pharmaceutics, Institute of Pharmacy, Ankara, Turkey.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2022


ABSTRACT:
The present study aimed to develop an immediate release of Zolmitriptan hydrochloride oral jellies for the treatment of severe migraine. The jellies were prepared by using chitosan hydrochloride with different concentration as a polymer and propylene glycol as a co-polymer. The prepared jellies were evaluated for its various physio-chemical parameters such as pH, appearance, viscosity, in vitro drug release and drug content. The pH of the prepared formulations was found to be in the range of 7.5-8.1. The appearance of the prepared formulations was transparent to opaque. The viscosity of the prepared jellies was found to be in the range of 273600 - 542335 CPS. The drug content of the prepared jellies was found to be more than 97%. The in vitro drug release immediate release with increased concentration of Chitosan Hydrochloride, and the drug release were found to be more than 60% in 15 minutes. This present studies concluded that Zolmitriptan hydrochloride oral jellies can be a better alternative for oral dispersible tablets and it could produce improved bioavailability as compared to other fast releasing dosage form. From the above studies of various parameters, it was concluded that the FJ5 formulation was found to be optimized formulation.


Cite this article:
Wajid Ahmad, Rihan Jawed. Formulation and Evaluation of Chewable Oral Jelly containing Zolmitriptan hydrochloride. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):139-4. doi: 10.52711/0975-4377.2022.00022

Cite(Electronic):
Wajid Ahmad, Rihan Jawed. Formulation and Evaluation of Chewable Oral Jelly containing Zolmitriptan hydrochloride. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):139-4. doi: 10.52711/0975-4377.2022.00022   Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-2-7


REFERENCE:
1.    Aminoff, Roger P. Simon, David A. Greenberg, Michael J. Clinical neurology (7 ed.). New York, N.Y: Lange Medical Books/McGraw-Hill. (2009) pp. 85–88.
2.    Malviya VR, Pande SD, Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-629.
3.    Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
4.    Raja Manali M, Dhiren P, Oral medicated jelly: a recent advancement in formulation, An International Journal of Pharmaceutical Sciences, 2016; 7(2):13-20.
5.    Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
6.    Raut S, Uplanchiwar V, Bhadoria S, Gahane A, Jain SK, Patil S. Comparative evaluation of zidovudine loaded hydrogels and emulgels. Research Journal of Pharmacy and Technology. 2012;5(1):41-5.
7.    Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
8.    Kumar L. An Overview on Preparation and Evaluation of Microparticulated Intra-Vaginal Gel. Research Journal of Pharmacy and Technology. 2009;2(1):48-51.
9.    Shah RR, Magdum CS, Wadkar KA, Naikwade NS. Fluconazole topical microemulsion: preparation and evaluation. Research Journal of Pharmacy and Technology. 2009;2(2):353-7.
10.    Shete AS, Mohite VL, Yadav AV. Preparation and Evaluation of Mucilage of Ocimum Basilicum as a Gelling Agent. Research Journal of Pharmacy and Technology. 2008;1(3):201-3.
11.    Yadav AV, Urade MN. Preparation and evaluation of chitosan containing mucoadhesive buccal films of venlafaxine hydrochloride. Research Journal of Pharmacy and Technology. 2010;3(4):1213-7.
12.    Begum SA, Sree VP, Anusha V, Veronica ZK, Sree PV, Prameela K, Nazeema MD, Padmalatha K. Formulation and evaluation of pediatric oral soft jellies of salbutamol sulphate. Research Journal of Pharmacy and Technology. 2018;11(11):4939-45.
13.    Charyulu RN, Devi PP, Jose J, Shetty AV. Formulation and evaluation of mucoadhesive oral gel containing miconazole nitrate for oral candidiasis. Research Journal of Pharmacy and Technology. 2013;6(11):1251-7.
14.    Kumar R, Jose J, Mahin MM, Raut R, Masurkar S, Swamy VB. Formulation and Evaluation of Gels from Gum of Cissus refescence. Research Journal of Pharmacy and Technology. 2012;5(3):415-23.
15.    Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 1;14(3):1535-41.
16.    Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
17.    Singh S. Drug Stability Testing and Shelf-life Determination According to International Guidelines. Pharm. Technol. 1999; 23:68-88
18.    Singh S, Bakshi M. Development of stability-indicating assay methods-A critical review. J. Pharm. Biomed. Anal. 2002; 28:1011-1040.
19.    Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31;14(10):5345-50.
20.    Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.

Recomonded Articles:

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Ashok Thulluru, K. Saravanakumar, Ch. S. Phani Kumar, Nawaz Mahammed, D. Sreeja, G. Bhuvanesh, N. Vamsi Chowdary, Nayeema Khowser Shaik

DOI: 10.5958/0975-4377.2019.00049.1         Access: Open Access Read More

Author(s): Varsha R. Sandhan, S.B. Gondkar, R. B. Saudagar

DOI:         Access: Open Access Read More

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Author(s): Masheer Ahmed Khan

DOI:         Access: Open Access Read More

Author(s): Shoaib Ahmad

DOI: 10.5958/0975-4377.2016.00041.0         Access: Open Access Read More

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0         Access: Open Access Read More

Author(s): V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren

DOI:         Access: Open Access Read More

Author(s): Abhijit Chormale, Dharmendra Mundhada, Rajesh Mujoriya

DOI: 10.5958/0975-4377.2015.00026.9         Access: Open Access Read More

Author(s): Samadhan K. Deore, Rajendra K Surawase, Avish Maru

DOI: 10.5958/0975-4377.2019.00045.4         Access: Open Access Read More

Author(s): Nakkala Balaji , V. Sai Kishore , Kasani Hari Krishna Gouda

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags