Author(s): Pallavi Wadaskar, Pallavi Kharkar, Pallavi Ispade

Email(s): Email ID Not Available

DOI: 10.52711/0975-4377.2022.00016   

Address: Pallavi Wadaskar*, Pallavi Kharkar, Pallavi Ispade
P.R. Pote Patil College of Pharmacy, Kathora Road Amravati-444604.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2022


ABSTRACT:
Crystallo-co-agglomeration (CCA) is an innovative technique developed with the intention to produce the drugs with good micromeritic and mechanical characteristics. Yohimbine Hydrochlorideis an anti-retroviral drug with poor dissolution and poor flow properties. Hence the aim of the study is to prepare the crystallo co-agglomerates of Yohimbine Hydrochloridewhich may improve the properties of Yohimbine Hydrochloride.The present study was carried out in order to develop pharmaceutically equivalent, stable, and quality improved agglomerates of Yohimbine Hydrochloridewith enhanced solubility wettability, dissolution rate, flow properties and mechanical properties using hydrophilic polymers and to characterize the physico-chemical properties of prepared crystallo-co-agglomeration.The present work was carried out using PVA and PEG 6000 as the polymers in different ratios by crystallo-co agglomeration method. The various evaluations of prepared agglomerates like micromeritics of the agglomerates such as flowability, packability and compatibility were dramatically improved. The dissolution and disintegration rate of agglomerate was increased in presence of PEG 6000 than compared with PVA.TheYohimbine Hydrochloridepolymer agglomerates were successfully prepared by crystallo-co-agglomeration technique and it was concluded that crystallo-co-agglomeration technique can be successfully employed as an alternative to conventional wet agglomeration.


Cite this article:
Pallavi Wadaskar, Pallavi Kharkar, Pallavi Ispade. Preparation and Evaluation of Yohimbine Hydrochloride Agglomerates by Crystallo Co-Agglomeration technique. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):105-0. doi: 10.52711/0975-4377.2022.00016

Cite(Electronic):
Pallavi Wadaskar, Pallavi Kharkar, Pallavi Ispade. Preparation and Evaluation of Yohimbine Hydrochloride Agglomerates by Crystallo Co-Agglomeration technique. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):105-0. doi: 10.52711/0975-4377.2022.00016   Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-2-1


REFERENCE:
1.    Sarath CC, Thomas JT, Vipin KV, Amitha S, (2016). Crystallo Co-agglomeration: An effective tool to change powder characteristics of Indomethacin IP. Int. J. Pharm. and Pharma. Res. IJPR, 7(4):197-207.
2.    Ranpise AA, Chaudhari SP, Phatak AA, Kadam PM. A review on spherical crystallization-the novel agglomeration technique. Research Journal of Pharmacy and Technology. 2012;5(10):1275-80.
3.    Rathi SG, Zala SA, Vaja MD, Vaghela SS. Formulation and evaluation of spherical crystal agglomerates of Lurasidone Hydrochloride. Research Journal of Pharmacy and Technology. 2021 Mar 1;14(3):1238-46.
4.    Butcher RL, Fugo NW. Endocrine Stimulating Effects of Yohimbine-HCl. Proceedings of the Society for Experimental Biology and Medicine. 1963 Aug;113(4):844-8.
5.    Riley AJ, Goodman RE, Kellett JM, Orr R. Double blind trial of yohimbine hydrochloride in the treatment of erection inadequacy. Sexual and Marital Therapy. 1989 Jan 1;4(1):17-26.
6.    Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
7.    Putta SK. Spherical agglomeration of telmisartan by quasi emulsion solvent diffusion technique to improve the solubility and dissolution rate. Research Journal of Pharmacy and Technology. 2016; 9(12): 2427-36.
8.    Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8): 624-9.
9.    Thati J, Chinta S. A Review on Spherical Crystallization Mechanisms and Characterization. Research Journal of Pharmacy and Technology. 2018; 11(1):412-7.
10.    Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020; 6(2): 94-100.
11.    Patil SV, Sahoo SK. Spherical Crystallization: a method to improve tabletability. Research Journal of Pharmacy and Technology. 2009; 2(2): 234-7.
12.    Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31; 13(3): 4942-51.
13.    Ranpise AA, Chaudhari SP, Phatak AA, Kadam PM. A review on spherical crystallization-the novel agglomeration technique. Research Journal of Pharmacy and Technology. 2012;5(10):1275-80.
14.    Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
15.    Jadhav NR, Paradkar AR, Shah GN. Adsorption studies of bromhexine hydrochloride on talc. Research J. Pharm. and Tech. 2013 Nov 28;6(11):1247-50.
16.    Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
17.    Gambhire MS, Gambhire VM, Maske K. Dissolution enhancement of clarithromycin by formation of surfactant containing microparticles. Research Journal of Pharmacy and Technology. 2010;3(1):199-201.
18.    Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.

Recomonded Articles:

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2017.00022.2         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7         Access: Open Access Read More

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI:         Access: Open Access Read More

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8         Access: Open Access Read More

Author(s): P. Lekshmi, K. Pramod, K.C. Ajithkumar

DOI: 10.5958/0975-4377.2016.00007.0         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2018.00036.8         Access: Open Access Read More

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X         Access: Open Access Read More

Author(s): Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe

DOI:         Access: Open Access Read More

Author(s): Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge

DOI: 10.5958/0975-4377.2018.00032.0         Access: Open Access Read More

Author(s): Viswanadham Manasa, K.Vanitha, M. Venkataswamy, P. Prabhakar, Alluri Ramesh

DOI: 10.5958/0975-4377.2016.00002.1         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags