Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Liquisolid Compact Techniques: A Review

Author(s): Amol S. Deshmukh, Vinod G. Mahale, Vijay R. Mahajan

Email(s): meamoldeshmukh@rediffmail.com

DOI: Not Available

Address: Amol S. Deshmukh*, Vinod G. Mahale, Vijay R. Mahajan
Department of Pharmaceutics, SMBT College of Pharmacy, Nandi Hills, Dhamangaon, Igatpuri, Nasik, India *Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2014

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ABSTRACT:
Oral drug administration has been one of the most convenient and widely accepted route of delivery for most of the therapeutic agents. It is one of the most extensively used routes of drug administration because of its obvious advantages of ease of administration, improved patient compliance, and convenience. The bioavailability of many poorly water-soluble drugs is limited by their dissolution rates which are in turn controlled by the effective surface area present for dissolution. The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects of drug development. A more recent technique, “powdered solution technology” or “Liquisolid technology”, has been applied to prepare water-insoluble drugs into rapid-release solid dosage forms. The limited solubility of drugs is a challenging issue for industry, during the development of the ideal solid dosage form unit. Liquisolid technique is a novel and promising approach to overcome this consequence. The technique is based upon the dissolving the insoluble drug in the nonvolatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptably flowing and compressible powders. The selection of non toxic hydrophilic solvent, carrier, coating materials and its ratios are independent of the individual chemical moieties. The increased bioavailability is due to either increased surface area of drug available for release, an increased aqueous solubility of the drug, or improved wettability of the drug particles.


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Cite this article:
Amol S. Deshmukh, Vinod G. Mahale, Vijay R. Mahajan. Liquisolid Compact Techniques: A Review. Res. J. Pharm. Dosage Form. and Tech. 6(3):July- Sept. 2014; Page 161-166.

Cite(Electronic):
Amol S. Deshmukh, Vinod G. Mahale, Vijay R. Mahajan. Liquisolid Compact Techniques: A Review. Res. J. Pharm. Dosage Form. and Tech. 6(3):July- Sept. 2014; Page 161-166.   Available on: https://rjpdft.com/AbstractView.aspx?PID=2014-6-3-3


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DOI: 10.5958/0975-4377 

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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