Liquisolid Technique for Enhancing Dissolution Rate: A Review

A.D. Deshmukh; S.R. Wasankar; R.M. Burghate; M.A. Ughade

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

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Liquisolid Technique for Enhancing Dissolution Rate: A Review

Author(s): A.D. Deshmukh, S.R. Wasankar, R.M. Burghate, M.A. Ughade

Email(s): abhishekpharma0289@gmail.com

DOI: Not Available

Address: A.D. Deshmukh*, S.R. Wasankar, R.M. Burghate, M.A. Ughade
Vidyabharti College of Pharmacy, Camp Road, Amravati, Maharashtra, 444602
*Corresponding Author

Published In: Volume - 5, Issue - 1, Year - 2013

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ABSTRACT:
The bioavailability of many poorly water-soluble drugs is limited by their dissolution rates which are in turn controlled by the effective surface area present for dissolution Therapeutic effectiveness of a drug depends upon the bioavailability. Solubility is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. The enhancement of oral bioavailability of poorly water soluble drugs remains one of the most challenging aspects of drug development. A more recent technique, “Liquisolid technology” or “powdered solution technology” has been applied to prepare water-insoluble drugs into rapid-release solid dosage forms. The technique is based upon the dissolving the insoluble drug in the nonvolatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptably flowing and compressible powders.

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Cite this article:
A.D. Deshmukh, S.R. Wasankar, R.M. Burghate, M.A. Ughade. Liquisolid Technique for Enhancing Dissolution Rate: A Review. Research J. Pharma. Dosage Forms and Tech. 2013; 5(1): 01-06.

Cite(Electronic):
A.D. Deshmukh, S.R. Wasankar, R.M. Burghate, M.A. Ughade. Liquisolid Technique for Enhancing Dissolution Rate: A Review. Research J. Pharma. Dosage Forms and Tech. 2013; 5(1): 01-06. Available on: https://rjpdft.com/AbstractView.aspx?PID=2013-5-1-1

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DOI: 10.5958/0975-4377