Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Solubility Enhancement of Poorly Aqueous Soluble Drug-Simvastatin by Using Chitosan

Author(s): Seema V. Pattewar

Email(s): dpattewar@yahoo.com

DOI: Not Available

Address: Seema V. Pattewar*
Sanjivani Institute of Pharmacy and Research, Kopargaon, India-423603
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2012

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ABSTRACT:
The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) to produce cost effective formulation. Physical mixture, co-grinding method, spray drying method are compared. Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.


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Cite this article:
Seema V. Pattewar. Solubility Enhancement of Poorly Aqueous Soluble Drug-Simvastatin by Using Chitosan. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1):56-61 .

Cite(Electronic):
Seema V. Pattewar. Solubility Enhancement of Poorly Aqueous Soluble Drug-Simvastatin by Using Chitosan. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1):56-61 .   Available on: https://rjpdft.com/AbstractView.aspx?PID=2012-4-1-10


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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

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DOI: 10.5958/0975-4377 

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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