Author(s): Seema V. Pattewar

Email(s): dpattewar@yahoo.com

DOI: Not Available

Address: Seema V. Pattewar*
Sanjivani Institute of Pharmacy and Research, Kopargaon, India-423603
*Corresponding Author

Published In:   Volume - 4,      Issue - 1,     Year - 2012


ABSTRACT:
The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) to produce cost effective formulation. Physical mixture, co-grinding method, spray drying method are compared. Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.


Cite this article:
Seema V. Pattewar. Solubility Enhancement of Poorly Aqueous Soluble Drug-Simvastatin by Using Chitosan. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1):56-61 .


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