Development of Controlled Release Floating Beads of Ibuprofen using Ionotropic Gelation Technique

P.S. Salve

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Development of Controlled Release Floating Beads of Ibuprofen using Ionotropic Gelation Technique

Author(s): P.S. Salve

Email(s): pramodsalve77@yahoo.com

DOI: Not Available

Address: P.S. Salve*
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Mahatma Fuley Shaikshanik Parisar, Amravati Road, Nagpur – 440 033 (MS)
*Corresponding Author:

Published In: Volume - 3, Issue - 6, Year - 2011

View HTML

View PDF

ABSTRACT:
The floating beads of ibuprofen were developed to provide controlled release in stomach. The beads were developed by ionotropic gelation of low methoxy pectin with calcium ions. The drug loading was kept at 25, 50 and 75 %w/w of low methoxy pectin (LMP). Sesame oil was used to provide floating characteristic in 10, 20 and 30 %w/w of (LMP). The beads were cross-linked with 2, 4 and 10 %w/v CaCl2 solution and further coated with 1 %w/v solution of deacetylated chitosan in 3 %w/v acetic acid. The interaction of low methoxy pectin with calcium ions and deacetylated chitosan was studied by differential scanning calorimetry, x-ray diffraction spectroscopy and FT-IR spectroscopy. The in-vitro buoyancy studies were carried in pH 1.2 buffer. The polymeric beads containing 20 and 30 %w/v oil showed excellent floating while beads containing 10 %w/v oil were found to be non-floating. The dissolution studies were carried in pH 1.2 buffer, pH 1.2 buffer containing 1% SLS and pH 6.8 phosphate buffer. A significantly low amount of drug release was observed in pH 1.2 buffer due to limited solubility of obuprofen in acidic media and faster drug release was observed in pH 6.8 phosphate buffer. A faster drug release was observed in pH 1.2 buffer containing sodium lauryl sulphate.

Keywords:

Cite this article:
P.S. Salve. Development of Controlled Release Floating Beads of Ibuprofen using Ionotropic Gelation Technique. Research J. Pharma. Dosage Forms and Tech. 2011; 3(6): 260-268.

Recomonded Articles:

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

Pharmaceutical Suspensions: Pharmacist has the Very Best Possible Formulation for the Job at Hand.

Author(s): Praneta Desale

DOI: Access: Open Access Read More

Comparative Standardization of Two Marketed Preparation of Gulwel churna

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2 Access: Open Access Read More

Formulation and Evaluation of Ondansetron Floating Tablet

Author(s): Lokesh Patle

DOI: 10.5958/0975-4377.2017.00028.3 Access: Open Access Read More

Co-Processed Excipients for Tabletting

Author(s): P. Lekshmi, K. Pramod, K.C. Ajithkumar

DOI: 10.5958/0975-4377.2016.00007.0 Access: Open Access Read More

Microemulsion: A Current Review

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5 Access: Open Access Read More

Formulation and Evaluation of Floating Matrix Tablets of Acyclovir using 32 Factorial Design

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0 Access: Open Access Read More

Formulation and Evaluation of Diclofenac Suspension by Using Natural Suspending Agents

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X Access: Open Access Read More

Formulation Development and Evaluation of Floating Drug Delivery System for H2-Blocker Drug (Roxatidine Acetate)

Author(s): Rajesh Mujoriya, Dharmendra Mundhada, Sangram Pawar

DOI: 10.5958/0975-4377.2016.00026.4 Access: Open Access Read More

Formulation and Evaluation of Effervescent Floating Tablets of Procainamide

Author(s): B. Saraswathi, R. Jagadeesh Reddy, P. Swathi, G. Manasa

DOI: 10.5958/0975-4377.2017.00025.8 Access: Open Access Read More

Evaluation Study of Sustained Release Ocular Insert of Brimonidine Tartrate and Timolol

Author(s): R. Z. Mujoriya, M. D. Kshirsagar

DOI: 10.5958/0975-4377.2016.00032.X Access: Open Access Read More

Designing and Evaluation of Floating Microspheres of Verapamil Hydrochloride: Effect of Methocel

Author(s): Manish P Patel, MM Patel, KN Patel, DR Patel,UL Patel

DOI: Access: Open Access Read More

Glimepiride Micro balloons: A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Author(s): Rutuja R. Shah, Rutuja S. Shah, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00030.1 Access: Open Access Read More

Preparation and Evaluation of Pantoprazole sodium floating microspheres

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI: Access: Open Access Read More

Evaluation of Seed Mucilage of Hibiscus Sabdariffa Linn as Tablet Binder

Author(s): Ch. Anupama, P. Padmakumari, K. Abbulu, Arti Mohan, A. Ppratyusha

DOI: Access: Open Access Read More

A Short Review on the Formulation of Transdermal Dermal Drug Delivery System (TDDS)

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9 Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377