Development of Controlled Release Floating Beads of Ibuprofen using Ionotropic Gelation Technique

P.S. Salve

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Development of Controlled Release Floating Beads of Ibuprofen using Ionotropic Gelation Technique

Author(s): P.S. Salve

Email(s): pramodsalve77@yahoo.com

DOI: Not Available

Address: P.S. Salve*
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Mahatma Fuley Shaikshanik Parisar, Amravati Road, Nagpur – 440 033 (MS)
*Corresponding Author:

Published In: Volume - 3, Issue - 6, Year - 2011

View HTML

View PDF

ABSTRACT:
The floating beads of ibuprofen were developed to provide controlled release in stomach. The beads were developed by ionotropic gelation of low methoxy pectin with calcium ions. The drug loading was kept at 25, 50 and 75 %w/w of low methoxy pectin (LMP). Sesame oil was used to provide floating characteristic in 10, 20 and 30 %w/w of (LMP). The beads were cross-linked with 2, 4 and 10 %w/v CaCl2 solution and further coated with 1 %w/v solution of deacetylated chitosan in 3 %w/v acetic acid. The interaction of low methoxy pectin with calcium ions and deacetylated chitosan was studied by differential scanning calorimetry, x-ray diffraction spectroscopy and FT-IR spectroscopy. The in-vitro buoyancy studies were carried in pH 1.2 buffer. The polymeric beads containing 20 and 30 %w/v oil showed excellent floating while beads containing 10 %w/v oil were found to be non-floating. The dissolution studies were carried in pH 1.2 buffer, pH 1.2 buffer containing 1% SLS and pH 6.8 phosphate buffer. A significantly low amount of drug release was observed in pH 1.2 buffer due to limited solubility of obuprofen in acidic media and faster drug release was observed in pH 6.8 phosphate buffer. A faster drug release was observed in pH 1.2 buffer containing sodium lauryl sulphate.

Keywords:

Cite this article:
P.S. Salve. Development of Controlled Release Floating Beads of Ibuprofen using Ionotropic Gelation Technique. Research J. Pharma. Dosage Forms and Tech. 2011; 3(6): 260-268.

Cite(Electronic):
P.S. Salve. Development of Controlled Release Floating Beads of Ibuprofen using Ionotropic Gelation Technique. Research J. Pharma. Dosage Forms and Tech. 2011; 3(6): 260-268. Available on: https://rjpdft.com/AbstractView.aspx?PID=2011-3-6-4

Recomonded Articles:

Pharmaceutical Suspensions: Pharmacist has the Very Best Possible Formulation for the Job at Hand.

Author(s): Praneta Desale

DOI: Access: Open Access Read More

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

A Systematic Review on COVID 19 Treatment and Management

Author(s): Isha Shah, Nensi Raytthatha, Jigar Vyas, Umesh Upadhyay

DOI: 10.52711/0975-4377.2021.00039 Access: Open Access Read More

A Brief Review on Intra-Uterine Drug Delivery Systems

Author(s): Suyash Ingle, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha

DOI: 10.5958/0975-4377.2021.00013.6 Access: Open Access Read More

Formulation and Evaluation of Ondansetron Floating Tablet

Author(s): Lokesh Patle

DOI: 10.5958/0975-4377.2017.00028.3 Access: Open Access Read More

Comparative Standardization of Two Marketed Preparation of Gulwel churna

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2 Access: Open Access Read More

Microemulsion: A Current Review

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5 Access: Open Access Read More

Preparation and Evaluation of Pantoprazole sodium floating microspheres

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI: Access: Open Access Read More

Taste Masking, Formulation and Evaluation of Orally Disintegrating Tablet of Anti-histaminic Drug

Author(s): Tejas Shah

DOI: Access: Open Access Read More

Glimepiride Micro balloons: A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Author(s): Rutuja R. Shah, Rutuja S. Shah, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00030.1 Access: Open Access Read More

Formulation Development and Evaluation of Floating Drug Delivery System for H2-Blocker Drug (Roxatidine Acetate)

Author(s): Rajesh Mujoriya, Dharmendra Mundhada, Sangram Pawar

DOI: 10.5958/0975-4377.2016.00026.4 Access: Open Access Read More

Formulation and Evaluation of Floating Matrix Tablets of Acyclovir using 32 Factorial Design

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0 Access: Open Access Read More

Pellets as Controlled Release Drug Delivery System: A Review

Author(s): Sapkal SR, Jaiswal SB, Chandewar AV, Gaikwad SB, Pathan AM

DOI: Access: Open Access Read More

Formulation and Evaluation of Diclofenac Suspension by Using Natural Suspending Agents

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X Access: Open Access Read More

Development and Optimization of Floating Tablets Containing Rebamipide

Author(s): Jigar Vyas, Jai Mehta, Neha Pal, Kapil Daxini

DOI: 10.5958/0975-4377.2020.00002.6 Access: Open Access Read More

Co-Processed Excipients for Tabletting

Author(s): P. Lekshmi, K. Pramod, K.C. Ajithkumar

DOI: 10.5958/0975-4377.2016.00007.0 Access: Open Access Read More

A Short Review on the Formulation of Transdermal Dermal Drug Delivery System (TDDS)

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9 Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377