Development of Controlled Release Floating Beads of Ibuprofen using Ionotropic Gelation Technique

P.S. Salve

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

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Development of Controlled Release Floating Beads of Ibuprofen using Ionotropic Gelation Technique

Author(s): P.S. Salve

Email(s): pramodsalve77@yahoo.com

DOI: Not Available

Address: P.S. Salve*
Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Mahatma Fuley Shaikshanik Parisar, Amravati Road, Nagpur – 440 033 (MS)
*Corresponding Author:

Published In: Volume - 3, Issue - 6, Year - 2011

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ABSTRACT:
The floating beads of ibuprofen were developed to provide controlled release in stomach. The beads were developed by ionotropic gelation of low methoxy pectin with calcium ions. The drug loading was kept at 25, 50 and 75 %w/w of low methoxy pectin (LMP). Sesame oil was used to provide floating characteristic in 10, 20 and 30 %w/w of (LMP). The beads were cross-linked with 2, 4 and 10 %w/v CaCl2 solution and further coated with 1 %w/v solution of deacetylated chitosan in 3 %w/v acetic acid. The interaction of low methoxy pectin with calcium ions and deacetylated chitosan was studied by differential scanning calorimetry, x-ray diffraction spectroscopy and FT-IR spectroscopy. The in-vitro buoyancy studies were carried in pH 1.2 buffer. The polymeric beads containing 20 and 30 %w/v oil showed excellent floating while beads containing 10 %w/v oil were found to be non-floating. The dissolution studies were carried in pH 1.2 buffer, pH 1.2 buffer containing 1% SLS and pH 6.8 phosphate buffer. A significantly low amount of drug release was observed in pH 1.2 buffer due to limited solubility of obuprofen in acidic media and faster drug release was observed in pH 6.8 phosphate buffer. A faster drug release was observed in pH 1.2 buffer containing sodium lauryl sulphate.

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Cite this article:
P.S. Salve. Development of Controlled Release Floating Beads of Ibuprofen using Ionotropic Gelation Technique. Research J. Pharma. Dosage Forms and Tech. 2011; 3(6): 260-268.

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DOI: 10.5958/0975-4377