Compatibility Studies Between Gatifloxacin and Pharmaceutical Excipients through Differential Scanning Calorimetry and Infra Red Spectroscopy

Rajendra Jangde; Rahul Singhour; SJ Daharwal

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Compatibility Studies Between Gatifloxacin and Pharmaceutical Excipients through Differential Scanning Calorimetry and Infra Red Spectroscopy

Author(s): Rajendra Jangde, Rahul Singhour, SJ Daharwal

Email(s): rjangdepy@gmail.com

DOI: Not Available

Address: Rajendra Jangde1*, Rahul Singhour2 and SJ Daharwal1
1University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492010 India
2Aristo Pharmaceutical Mandideep, Bhopal (M.P.), India
*Corresponding Author

Published In: Volume - 2, Issue - 1, Year - 2010

View HTML

View PDF

ABSTRACT:
Proper formulation is an important aspect of any dosage form design. FT-IR and Differential scanning calorimeter were used to evaluate the compatibility of Gatifloxacin and selected Excipients used in the development of suspensions formulation. In the first phase of Differential scanning calorimeter was used in the any interaction. In the next phase, excipients defined as prototype formula were tested for their compatibility with Gatifloxacin. Based on the results, methyl paraben and polyvinyl pyrrolidone were found show interaction with Gatifloxacin. Results of Differential scanning calorimeter and FT-IR demonstrated incompatibility between Gatifloxacin and MethylParaben. All the excipients defined in the prototype formula were found to be compatible with Gatifloxacin. Using the Excipients that were found to be compatible with Gatifloxacin. FT-IR and Differential scanning calorimetry was used to investigate the physicochemical compatibility between Gatifloxacin and various used in suspension manufacturing. The Gatifloxacin found to be compatatible with polyvinyl alcohol and acacia. Although interactions of Gatifloxacin with methyl paraben, polyvinyl pyrrolidone were observed. It cannot be conclusive stasted that interactions incompatibility will occur during storage at room temperature.

Keywords:

Cite this article:
Rajendra Jangde, Rahul Singhour, SJ Daharwal. Compatibility Studies Between Gatifloxacin and Pharmaceutical Excipients through Differential Scanning Calorimetry and Infra Red Spectroscopy. Research J. Pharma. Dosage Forms and Tech. 2010; 2(1):103-106

Recomonded Articles:

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

Formulation Development and Evaluation of Capsule Containing Fluclaxacillin Sodium and Amoxicillin Trihydrate with Enteric Coated Granules of Lactic Acid Bacillus

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI: Access: Open Access Read More

Formulation and Evaluation of Fast Dissolving Tablets of Trimetazidine Dihydrochloride Using Natural and Synthetic Superdisintegrants

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6 Access: Open Access Read More

Formulation and Development of Ethyl cellulose coated Pectin based Capecitabine Loaded Microspheres for Colorectal Cancer

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7 Access: Open Access Read More

Formulation and Evaluation of Fast Dissolving Tablets containing Clopidogrel bisulfate using holy basil seeds as a natural superdisintegrant

Author(s): Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge

DOI: 10.5958/0975-4377.2018.00032.0 Access: Closed Access Read More

Glimepiride Micro balloons: A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Author(s): Rutuja R. Shah, Rutuja S. Shah, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00030.1 Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377