Compatibility Studies Between Gatifloxacin and Pharmaceutical Excipients through Differential Scanning Calorimetry and Infra Red Spectroscopy

Rajendra Jangde; Rahul Singhour; SJ Daharwal

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

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Compatibility Studies Between Gatifloxacin and Pharmaceutical Excipients through Differential Scanning Calorimetry and Infra Red Spectroscopy

Author(s): Rajendra Jangde, Rahul Singhour, SJ Daharwal

Email(s): rjangdepy@gmail.com

DOI: Not Available

Address: Rajendra Jangde1*, Rahul Singhour2 and SJ Daharwal1
1University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492010 India
2Aristo Pharmaceutical Mandideep, Bhopal (M.P.), India
*Corresponding Author

Published In: Volume - 2, Issue - 1, Year - 2010

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ABSTRACT:
Proper formulation is an important aspect of any dosage form design. FT-IR and Differential scanning calorimeter were used to evaluate the compatibility of Gatifloxacin and selected Excipients used in the development of suspensions formulation. In the first phase of Differential scanning calorimeter was used in the any interaction. In the next phase, excipients defined as prototype formula were tested for their compatibility with Gatifloxacin. Based on the results, methyl paraben and polyvinyl pyrrolidone were found show interaction with Gatifloxacin. Results of Differential scanning calorimeter and FT-IR demonstrated incompatibility between Gatifloxacin and MethylParaben. All the excipients defined in the prototype formula were found to be compatible with Gatifloxacin. Using the Excipients that were found to be compatible with Gatifloxacin. FT-IR and Differential scanning calorimetry was used to investigate the physicochemical compatibility between Gatifloxacin and various used in suspension manufacturing. The Gatifloxacin found to be compatatible with polyvinyl alcohol and acacia. Although interactions of Gatifloxacin with methyl paraben, polyvinyl pyrrolidone were observed. It cannot be conclusive stasted that interactions incompatibility will occur during storage at room temperature.

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Cite this article:
Rajendra Jangde, Rahul Singhour, SJ Daharwal. Compatibility Studies Between Gatifloxacin and Pharmaceutical Excipients through Differential Scanning Calorimetry and Infra Red Spectroscopy. Research J. Pharma. Dosage Forms and Tech. 2010; 2(1):103-106

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DOI: 10.5958/0975-4377