Volume No. :   1

Issue No. :  3

Year :  2009

ISSN Print :  0975-234X

ISSN Online :  0975-4377


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Effect of Superdisintegrants on Olanzapine Oro-Dispersible Tablets

Address:   Satish K Mandlik*, Mehul M Joshi, Dinesh S Nandare, Pramod S Jagtap and Kishor S Jain
Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon Bk, Pune-411041
*Corresponding Author

This study investigated to compare the disintegration efficiency for the 5 classes of superdisintegrants represented by Cros-carmellose Sodium (CCS), Cros-povidone (CP), Polacrilin K (PK), Sodium Starch Glycolate (SSG), and L-Hydroxy Propyl Cellulose (L-HPC). Tablets were prepared by direct compression method. Effect of 5 superdisintegrants on disintegration time, dissolution parameters, and friability has been studied. Among all the superdisintegrants, a PK containing tablets has shown faster disintegration followed by SSG. Tablets containing L-HPC disintegrated after PK and SSG containing tablets. Where as disintegration time and dissolution parameters increased with increase in the level of Cros-carmellose in tablets. However the disintegration time value did not reflect in dissolution parameter values of cros-povidone tablets and release was dependent on aggregate size in dissolution medium.
Orodispersible Tablets, Olanzapine, Superdisintegrants.
Satish K Mandlik, Mehul M Joshi, Dinesh S Nandare, Pramod S Jagtap, Kishor S Jain. Effect of Superdisintegrants on Olanzapine Oro-Dispersible Tablets. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):233-235.
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