Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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To Study the effect of Cross linking of Sodium Alginate on the Rate of Drug Release

Author(s): Aachal Kolhe, Akshda Chauhan, Aishwarya Dongre

Email(s): Email ID Not Available

DOI: 10.52711/0975-4377.2022.00020   

Address: Aachal Kolhe*, Akshda Chauhan, Aishwarya Dongre
P.R. Pote Patil College of Pharmacy, Amravati, Kathora Road, Amravati-444604.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2022

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ABSTRACT:
Verapamil hydrochloride (VH) is a calcium channel blocking agent used in the treatment of hypertension, cardiac arrhythmia and angina pectoris. The short half life and high frequency of administration of VH makes it a suitable candidate for designing sustained drug delivery system. The aim of the present investigation was to develop a sustained release matrix tablet of verapamil hydrochloride (VH) using sodium alginate and cross linked sodium alginate and to evaluate the drug release kinetics. In order to achieve the required sustained release profile, the tablets were prepared by a wet granulation method. The formulated tablets were characterized for pre-compression and post-compression parameters and they were in the acceptable limits. The drug release data obtained after an in vitro dissolution study was fitted to various release kinetic models in order to evaluate the release mechanism and kinetics. The criterion for selecting the best fit model was linearity (coefficient of correlation). Drug release mechanism was found to follow a complex mixture of diffusion, swelling and erosion. The dosage form holds the potential to control the release rate of drug and extend the duration of action of a drug.


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Cite this article:
Aachal Kolhe, Akshda Chauhan, Aishwarya Dongre. To Study the effect of Cross linking of Sodium Alginate on the Rate of Drug Release. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):127-2. doi: 10.52711/0975-4377.2022.00020

Cite(Electronic):
Aachal Kolhe, Akshda Chauhan, Aishwarya Dongre. To Study the effect of Cross linking of Sodium Alginate on the Rate of Drug Release. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):127-2. doi: 10.52711/0975-4377.2022.00020   Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-2-5


REFERENCES:
1.    Sayed E, Haj-Ahmad R, Ruparelia K, Arshad MS, Chang MW, Ahmad Z. Porous inorganic drug delivery systems—A review. Aaps Pharmscitech. 2017 Jul;18(5):1507-25.
2.    Lee BJ, Ryu SG, Cui JH. Formulation and release characteristics of hydroxypropyl methylcellulose matrix tablet containing melatonin. Drug Development and Industrial Pharmacy. 1999 Jan 1;25(4):493-501.
3.    Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
4.    Barde LN, Mulye SV, Roy AA, Wankhede VP, Gabhane KB, Mathur VB, Shivhare UD, Bhusari KP. Development and In Vitro Evaluation of Extended Release Matrix Tablet of Metoprolol Succinate. Research Journal of Pharmacy and Technology. 2010;3(3):748-52.
5.    Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
6.    Kılıçarslan M, Baykara T. The effect of the drug/polymer ratio on the properties of the verapamil HCl loaded microspheres. International Journal of Pharmaceutics. 2003 Feb 18;252(1-2):99-109.
7.    Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
8.    Bawankar DL, Deshmane SV, More SM, Channawar MA, Chandewar AV, Shreekanth J. Design and Characterization of Extended Release Ranolazine Matrix Tablet. Research Journal of Pharmacy and Technology. 2009;2(4):756-61.
9.    Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
10.    Mahaparale PR, Kuchekar BS. Sustained release wax matrix tablet of Metoprolol succinate. Research Journal of Pharmacy and Technology. 2012;5(11):1408-12.
11.    Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
12.    Kathija M, Narayanaswamy VB. Formulation and Evaluation of Gastroretentive Matrix Tablet of Nifedipine. Research Journal of Pharmacy and Technology. 2015 May 28;8(5):549-53.
13.    Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
14.    Jawahar N, Vinothaboosan R, Venkatesh N, Kalirajan R, Eagappanath T. Design and Evaluation of Sustained Release Hydrophilic Polymer Matrix Tablet of Glucosamine Sulphate. Research Journal of Pharmacy and Technology. 2009;2(3):463-5.
15.    Bhoyar PK, Patil RP, Barokar AA, Baheti JR, Khandare RA, Gedam SS. Formulation and In-Vitro Evaluation of Aceclofenac Matrix Tablet For Colon Specific Drug Delivery: By Using Dextrin. Research Journal of Pharmacy and Technology. 2011;4(4):527-9.
16.    Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
17.    Hingmire LP, Deshmukh VN, Sakarkar DM. Development and evaluation of sustained release matrix Tablets using natural polymer as release modifier. Research Journal of Pharmacy and Technology. 2008;1(3):193-6.
18.    Shinde RV, Pawar JB, Kadam SD, Landge DA, Rahul A, Kulkarni V, Patil VG, Pawar GR. Development and In Vitro Evaluation of Sustained Release Matrix Tablet Formulations of Metoprolol Tartrate. Research Journal of Pharmacy and Technology. 2010;3(2):512-7.

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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