Development and Characterization of Lipospheres Containing Repaglinide

Misbah Nikhath; Vazir Ashfaq Ahmed

doi:10.52711/0975-4377.2022.00018

Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)

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Development and Characterization of Lipospheres Containing Repaglinide

Author(s): Misbah Nikhath, Vazir Ashfaq Ahmed

Email(s): misbahmissu143@gmail.com

DOI: 10.52711/0975-4377.2022.00018

Address: Misbah Nikhath, Vazir Ashfaq Ahmed
Department of Pharmaceutics, M.M.U College of Pharmacy, Ramanagaram.
*Corresponding Author

Published In: Volume - 14, Issue - 2, Year - 2022

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ABSTRACT:
Lipospheres formulation is an aqueous micro dispersion of solid water insoluble spherical micro the lipospheres are prepared of solid hydrophobic triglycerides with a monolayer of phospholipids embedded on the shell of the particle. Repaglinide is a water insoluble ant diabetic drug which belongs to the class of medications known as meglitinides. An attempt was made to develop and characterized the lipospheres in order to enhance the bioavailability of a highly permeable and a poorly soluble anti-diabetic drug by using different concentrations of bees wax, stearic acid, cetyl alcohol, tween 80 and phospholipids coat such as soybean phosphotidylcholine. The lipospheres were prepared by solvent evaporation technique and characterized for particle size, scanning electron microscopy, % entrapment efficiency, % yield, % drug content, in vitro drug release and stability study. All the formulation gave the satisfactory result in terms of particle size, entrapment efficiency and drug content. Lipospheres were substantially stable after 3 months storage at 2–8°C.

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Cite this article:
Misbah Nikhath, Vazir Ashfaq Ahmed. Development and Characterization of Lipospheres Containing Repaglinide. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):117-2. doi: 10.52711/0975-4377.2022.00018

Cite(Electronic):
Misbah Nikhath, Vazir Ashfaq Ahmed. Development and Characterization of Lipospheres Containing Repaglinide. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(2):117-2. doi: 10.52711/0975-4377.2022.00018 Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-2-3

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DOI: 10.5958/0975-4377