Author(s): Neha O. Mankar, Yogita R. Mandlik, Chandrashekhar B. Chauriya

Email(s): nmankar48@gmail.com

DOI: 10.52711/0975-4377.2021.00021   

Address: Neha O. Mankar, Yogita R. Mandlik, Chandrashekhar B. Chauriya
Ravi Institute of Diploma in Pharmacy, Mahadula, Koradi, Nagpur.
*Corresponding Author

Published In:   Volume - 13,      Issue - 2,     Year - 2021


ABSTRACT:
Citrus limonoids (CLs) are a group of highly oxygenated terpenoid found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, pumellos, oranges, grapefruits, bergamots, and mandarins. [10] The term limonoids was derived from limonin, which is the first tetranortriterpenoid obtained from bitter principles of citrus [6]. CLs are found as both free aglycones and corresponding -D glucosides, the former mostly occurring in seeds while the latter are formed during fruit maturation. Conversion of agycon to glycon is carried out by two enzymes, uridine diphosphoglucose- limonoid glycosyl t ransferase and limonoid D-ring lactone hydrolase. [8,9]. Glucosides have an open D ring to accommodate an attached glucose moiety; in aglycones the D-ring is closed [9] Citrus fruits are particularly high in a class of phytochemicals known as the limonoids1and recent research suggests that limonoids appearto possess substantial anticancer activity. [7] The present review focused on pharmacological studies of citrus limonoids as an anticancer agent.


Cite this article:
Neha O. Mankar, Yogita R. Mandlik, Chandrashekhar B. Chauriya. Limonoids as an effective Anticancer Agent: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(2):118-0. doi: 10.52711/0975-4377.2021.00021

Cite(Electronic):
Neha O. Mankar, Yogita R. Mandlik, Chandrashekhar B. Chauriya. Limonoids as an effective Anticancer Agent: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(2):118-0. doi: 10.52711/0975-4377.2021.00021   Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-2-6


REFERENCES:
1. Hasegawa S, Fong C, Herman Z, and Miyak M. Publication Date: M 1992, Glucosides of limonoids doi: 10.1021/bk-1992-0490.ch00
2. Miller E, Taylor S, Berry C, Zimmerman J, and Hasegawa S.; 2000, Citrus Limonoids: Increasing Importance as Anticancer Agents, : doi: 10.1021/bk-2000-0758.ch010
3. Jacob R, Hasegawa S and Manners G.; 2000 The Potential of Citrus Limonoids as Anticancer Agents Perishables Handling Quarterly Issue No. 102
4. Miller E, Porter J, Binnie W, Guo I, and Hasegawa S.; 2004, Further Studies on the Anticancer Activity of Citrus Limonoids, J. Agric. Food Chem., 52, 4908−4912
5. Poulose S, Harris E, and Patil B.; 2005, Citrus Limonoids Induce Apoptosis in Human Neuroblastoma Cells and Have Radical Scavenging Activity, J. Nutr. 135: 870–877, 
6. Roy A. and Saraf S.; 2006 Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom Biol. Pharm. Bull. 29(2) 191—201 
7. Ejaz S, Ejaz A, Matsuda k and Chae Woong Lim.; 2006 Limonoids as cancer chemopreventive agents Sci Food Agric 86:339–345, DOI: 10.1002/jsfa.2396
8. Poulose S, Harris E, & Patil B.; 2009, Antiproliferative Effects of Citrus Limonoids Against Human Neuroblastoma and Colonic Adenocarcinoma Cells, Nutrition and Cancer, 56:1, 103-112, DOI: 10.1207/s15327914nc5601_14
9. Gyawali R and Kim K..; 2014, Anticancer Phytochemicals of Citrus Fruits –A Review, DOI Number 10.5958/2277-940X..00079.5
10. Gualdani R, Cavalluzzi M, Lentini G, Habtemariam S.; 2016. The Chemistry and Pharmacology of Citrus Limonoids, DOI: 10.3390/molecules21111530
11. Gualdani R, Cavalluzzi M, Lentini G.; 2016 The Chemistry and Pharmacology of Citrus Limonoids 2016 Molecules, 21, 1530, 8 of 39
12. Patel M, Tripathy S, Mukhopadhyay K, Wangjam T, Cabang A, Morris J, and Wargovich M.; 2018, A Supercritical CO2 Extract of Neem Leaf (A. indica) and its Bioactive Liminoid, Nimbolide, Suppresses Colon Cancer in Preclinical Models by Modulating Pro-inflammatory Pathways DOI 10.1002/mc.22832
13. Sophia J, Kowshik J and Nagini S.; 2018, Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer, Cell Death & Disease volume 9, Article number: 1087 
14. Patra A, Satpathy S, and Hussain M.; 2019 Nanodelivery and anticancer effect of a limonoid, nimbolide, in breast and pancreatic cancer cells Int J Nanomedicine.; 14: 8095–8104
15. United state patent 29 may 2001 patent no.US 6, 239, 114, B1

Recomonded Articles:

Author(s): Saikumar Y., Saikishore V., Pavani K., Sairam D.T., Sindhura A.

DOI:         Access: Open Access Read More

Author(s): Swati S Talokar, Rohan R Vakhariya

DOI: 10.5958/0975-4377.2017.00001.5         Access: Open Access Read More

Author(s): Shoaib Ahmad

DOI: 10.5958/0975-4377.2016.00041.0         Access: Open Access Read More

Author(s): Haribansh Narayan Singh, Shivangi Saxena, Sunil Singh, Ajit Kumar Yadav

DOI:         Access: Open Access Read More

Author(s): Kiran R. Birajdar, Satish K. Mandlik

DOI: 10.5958/0975-4377.2017.00015.5         Access: Open Access Read More

Author(s): Chinmaya Keshari Sahoo, Surepalli Rammohan Rao, Muvvala Sudhakar, D. Venkata Ramana, Kanhu Charan Panda

DOI: 10.5958/0975-4377.2017.00024.6         Access: Open Access Read More

Author(s): P. B. Suruse, M. K. Kale, N. J. Duragkar, A. Gundawar

DOI:         Access: Open Access Read More

Author(s): Borkar Sudarshan, Shende Vikas, Chatap Viveknand, Sawant Vilas, R Suresh, Dama Ganesh

DOI:         Access: Open Access Read More

Author(s): P. Parveen, P. Usha, V. Vasu Naik, Sk. Shaheda Sultana, M. Gayatri Ramya

DOI:         Access: Open Access Read More

Author(s): Muthukumaran P., Abirami C. , Priyatharsini

DOI:         Access: Open Access Read More

Author(s): Rajesh Mujoriya , Ramesh Babu Bodla

DOI:         Access: Open Access Read More

Author(s): Namdeo G. Shinde, Nayana V. Pimpodkar

DOI: 10.5958/0975-4377.2015.00011.7         Access: Open Access Read More

Author(s): Mohit Soni, Daisy Sharma, Tejvir Kaur, Sandeep Kumar, GD Gupta

DOI:         Access: Open Access Read More

Author(s): P.Sivannarayana, A. Prameela Rani, V. Saikishore, Ch.VenuBabu, V. SriRekha

DOI:         Access: Open Access Read More

Author(s): Santosh J Pawar, Pruthviraj S Pawar, Sachin B Jadhav, Alkunte AS , Patil SM

DOI:         Access: Open Access Read More

Author(s): Anusha. V

DOI:         Access: Open Access Read More

Author(s): Vazir Ashfaq Ahmed, H.G. Shiv Kumar, K.L.K. Paranjothy, Mohd. Khaleel

DOI:         Access: Open Access Read More

Author(s): M. Sunitha Reddy, Sama Mallikarjun Reddy, A. Mahesh Chandra, B. Sai Santhosh, Ch. Surekha, K. Naveen

DOI:         Access: Open Access Read More

Author(s): Trilochan Satapathy, Prasanna Kumar Panda

DOI:         Access: Open Access Read More

Author(s): Anilkumar J Shinde, Harinath N More

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags