Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Formulation and Evaluation of Antidiabetic Herbal Capsules

Author(s): P. B. Suruse, M. K. Kale, N. J. Duragkar, A. Gundawar

Email(s): pravinsuruse@gmail.com

DOI: Not Available

Address: P. B. Suruse*, M. K. Kale, N. J. Duragkar and A. Gundawar
Sharad Pawar College of Pharmacy, Wanadongri, Hingna Road, Nagpur- 441 110 (MS), India.
*Corresponding Author:

Published In:   Volume - 4,      Issue - 2,     Year - 2012

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ABSTRACT:
The work presented here deals with formulation and evaluation of herbal antidiabetic capsule containing dried extracts of Gymnema sylvestre, Mucuna prurience and Ginkgo biloba. Phytochemical screenings of all three extracts were performed and their purity was checked by TLC, HPTLC and also by gravimetric method. While formulating the capsules three batches were selected with different concentration of extracts of Gymnema sylvestre and same quantity of Mucuna prurience and Ginkgo biloba extracts. The antidiabetic activity of three formulations was performed on diabetic rats to find out the better activity than others. The formulation 3 has given the better result as compared to formulation 1 and 2. For the pharmacological evaluation, all the experiments were designed and conducted as per CPCSEA and IAEC guidelines. The single dose study of optimized formulation shows a significant decrease in serum glucose level at 2, 4, 6 and 24 h while comparing with only extract of Gymnema sylvestre and standard antidiabetic drug Glibenclamide. The optimized formulation showed much better result as compared to extract of Gymnema sylvestre. Physical and chemical evaluation of optimized formulation has been performed and compared the peaks of standard drug with extracts and formulation by HPTLC analysis.


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Cite this article:
Formulation and Evaluation of Antidiabetic Herbal Capsules. P. B. Suruse, M. K. Kale, N. J. Duragkar, A. Gundawar. Research J. Pharma. Dosage Forms and Tech. 2011; 4(2): 113-118.

Cite(Electronic):
Formulation and Evaluation of Antidiabetic Herbal Capsules. P. B. Suruse, M. K. Kale, N. J. Duragkar, A. Gundawar. Research J. Pharma. Dosage Forms and Tech. 2011; 4(2): 113-118.   Available on: https://rjpdft.com/AbstractView.aspx?PID=2012-4-2-7


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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

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DOI: 10.5958/0975-4377 

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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