Ophthalmic Drug Delivery of Diclofenac Potassium from Different Polymer Formulations: In Situ Sol Gels

Vazir Ashfaq Ahmed; H.G. Shiv Kumar; K.L.K. Paranjothy; Mohd. Khaleel

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Ophthalmic Drug Delivery of Diclofenac Potassium from Different Polymer Formulations: In Situ Sol Gels

Author(s): Vazir Ashfaq Ahmed, H.G. Shiv Kumar, K.L.K. Paranjothy, Mohd. Khaleel

Email(s): vazirahmed@yahoo.co.in

DOI: Not Available

Address: Vazir Ashfaq Ahmed1*, H.G. Shiv Kumar2, K.L.K. Paranjothy3 and Mohd. Khaleel1
1Dept of Pharmaceutics, MMU College of Pharmacy, Ramanagram, Karnataka- India
2J.S.S. College of Pharmacy, Mysore, Karnataka- India
3AL-AMEEN College of Pharmacy, Bangalore, Karnataka- India
*Corresponding Author

Published In: Volume - 1, Issue - 2, Year - 2009

View HTML

View PDF

ABSTRACT:
The major purpose of this study was to investigate the effect of different polymers-based solutions as the in situ gelling vehicles for ophthalmic drug delivery. The rheological properties, in vitro release as well as in vivo studies by using various polymer solutions, like carbopol, pluronic and carbopol/pluronic solution, were evaluated. The optimum concentration of carbopol solution was 0.3% (w/v), pluronic solution was 13% (w/v). The mixture of 0.3% carbopol and 13% (w/v), pluronic solutions showed a significant enhancement in gel strength in the physiological condition; this gel mixture was also found to be free flowing . Both the in vitro release and in vivo pharmacological studies indicated that the carbopol/pluronic solution had the better ability to retain drug than the carbopol or pluronic solutions alone. The results demonstrated that the carbopol/pluronic mixture can be used as an in situ gelling vehicle to enhance the ocular bioavailability.

Keywords:

Cite this article:
Vazir Ashfaq Ahmed, H.G. Shiv Kumar, K.L.K. Paranjothy, Mohd. Khaleel. Ophthalmic Drug Delivery of Diclofenac Potassium from Different Polymer Formulations: In Situ Sol Gels. Research J. Pharma. Dosage Forms and Tech. 2009; 1(2): 158-161.

Cite(Electronic):
Vazir Ashfaq Ahmed, H.G. Shiv Kumar, K.L.K. Paranjothy, Mohd. Khaleel. Ophthalmic Drug Delivery of Diclofenac Potassium from Different Polymer Formulations: In Situ Sol Gels. Research J. Pharma. Dosage Forms and Tech. 2009; 1(2): 158-161. Available on: https://rjpdft.com/AbstractView.aspx?PID=2009-1-2-19

Recomonded Articles:

Transdermal Drug Delivery System of Antidiabetic Drugs: A Review

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI: Access: Open Access Read More

Formulation and Evaluation of Stable Montelukast Sodium Sublingual Tablet by using Lyophilization Technique

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7 Access: Open Access Read More

Enhancement of Solubility of Poorly Water Soluble Drug (Allopurinol) Through Solid Dispersion

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI: Access: Open Access Read More

Self Microemulsifying Drug Delivery System (SMEDDS): A Novel Approach to Improve the Therapeutic Efficacy of Orally Administered Drug

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0 Access: Open Access Read More

Glimepiride Micro balloons: A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Author(s): Rutuja R. Shah, Rutuja S. Shah, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00030.1 Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377