Author(s): Hamid Khan, Mushir Ali, Alka Ahuja, Javed Ali

Email(s): hamid_khan008@yahoo.co.in

DOI: 10.5958/0975-4377.2015.00029.4   

Address: Hamid Khan1*, Mushir Ali2, Alka Ahuja2, Javed Ali2
1JK College of Pharmacy, Bilaspur, CG, India-495001
2Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India-110062
*Corresponding Author

Published In:   Volume - 7,      Issue - 3,     Year - 2015


ABSTRACT:
The aim of the presented work was formulation and in-vitro evaluation of in-lay tablets containing telmisartan as sustained release outer core and hydrochlorothiazide as immediate release inner core using HPMC and co-polymer carbopol 71G. Tablets were evaluated via various quality control tests and in-vitro drug release studies. Drug release study was carried out hydrochloric acid buffer of pH 1.2 (0.1N) using USP paddle apparatus. The validated HPLC-UV method was applied to determine the amount of drugs released at different time intervals. The mechanism of drug release through polymeric network was established. Prepared tablets showed extended sustain release of telmisartan over a period of 20 h and hydrochlorothiazide as immediate release within 30 min.


Cite this article:
Hamid Khan, Mushir Ali, Alka Ahuja, Javed Ali. Formulation and In-Vitro Evaluation of In-lay Matrix Tablets Containing Telmisartan and Hydrochlorothiazide. Res. J. Pharm. Dosage Form. and Tech. 7(3): July-Sept., 2015; Page 193-198. doi: 10.5958/0975-4377.2015.00029.4


Recomonded Articles:

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI:         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2017.00022.2         Access: Open Access Read More

Author(s): Debjit Bhowmik, Amrendra Singh , Praveen Khirwadkar, Nishi Shukla, Vikas Kumar Chaudhari

DOI: 10.5958/0975-4377.2016.00027.6         Access: Open Access Read More

Author(s): Masheer Ahmed Khan

DOI:         Access: Open Access Read More

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI:         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8         Access: Open Access Read More

Author(s): B. Saraswathi, R. Jagadeesh Reddy, P. Swathi, G. Manasa

DOI: 10.5958/0975-4377.2017.00025.8         Access: Open Access Read More

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Author(s): Soham Shukla, Vikram Pandya, Praful Bhardia, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Deependra Jain

DOI:         Access: Open Access Read More

Author(s): Sachin N. Kothawade, Ashwini Ishware, Priyanka Darekar, Amit S. Lunkad

DOI:         Access: Open Access Read More

Author(s): Amit K. Jain, Rajput Rammulrajsinh, Pradeep Agrawal, Kinal patel

DOI:         Access: Open Access Read More

Author(s): Bhoyar PK, Biyani DM, Shahare HV, Ikhar PK,Borkar VS

DOI:         Access: Open Access Read More

Author(s): Sheema Nafees. S, Sayad Basha. K , Thirumalesh S.B

DOI: 10.5958/0975-4377.2016.00038.0         Access: Open Access Read More

Author(s): Pawar P.B. , Wagh M.P , Hiremath S.N, Baviskar A.V, Akul M.R.

DOI:         Access: Open Access Read More

Author(s): Susmitha. A, Narendra Babu. K, Imran Khan Pathan, Ishwarya. K

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags