A Novel visible spectrophotometric method development for the estimation of oseltamivir phosphate in capsules based on ferric hydroxamate reaction

B. Kalyana Ramu; M. Syam Bab; U. Viplava Prasad

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

A Novel visible spectrophotometric method development for the estimation of oseltamivir phosphate in capsules based on ferric hydroxamate reaction

Author(s): B. Kalyana Ramu, M. Syam Bab, U. Viplava Prasad

Email(s): kalyanaramu23566@gmail.com msyambab@gmail.com

DOI: Not Available

Address: B. Kalyana Ramu2*, M. Syam Bab1, U. Viplava Prasad1
1Department of Organic Chemistry& Analysis of Foods Drugs &water Laboratories, School of Chemistry, Andhra University, Visakhapatnam-530003 Andhra Pradesh (India)
2Department of Chemistry, Maharajah’s College (Aided& Autonomous), Vizianagaram-535002 (AP) India.
*Corresponding Author:

Published In: Volume - 5, Issue - 2, Year - 2013

View HTML

View PDF

ABSTRACT:
A Simple, sensitive spectrophotometric method in visible region was developed for the estimation of osetamivir phosphate in bulk and solid dosage forms. The method is based on the ferric hydroxamate reaction purple red colored species is formed with hydroxylamine-ferric per chlorate reagent in non aqueous medium which exhibits maximum absorption at 514 nm. Beer’s law obeyed in the concentration range of 20-60µg/ml. commercially available Natflu capsules were analyzed, and the results are statistically compared with those obtained by the UV reference method and validated by recovery studies. The results obtained by the proposed method were in good agreement with the labeled amounts and found satisfactory and reproducible. The method is applied successfully for the estimation of the Oseltamivir phosphate in the presence of other ingredients that are usually present in dosage forms. The method offers the advantages of rapidity, simplicity and sensitivity and normal cost and can be easily applied to resource-poor settings without the need for expensive instrumentation and reagents.

Keywords:

Cite this article:
B. Kalyana Ramu, M. Syam Bab, U. Viplava Prasad. A Novel visible spectrophotometric method development for the estimation of oseltamivir phosphate in capsules based on ferric hydroxamate reaction. Research J. Pharma. Dosage Forms and Tech. 2013; 5(2): 70-74

Cite(Electronic):
B. Kalyana Ramu, M. Syam Bab, U. Viplava Prasad. A Novel visible spectrophotometric method development for the estimation of oseltamivir phosphate in capsules based on ferric hydroxamate reaction. Research J. Pharma. Dosage Forms and Tech. 2013; 5(2): 70-74 Available on: https://rjpdft.com/AbstractView.aspx?PID=2013-5-2-5

Recomonded Articles:

Formulation Development and Evaluation of Capsule Containing Fluclaxacillin Sodium and Amoxicillin Trihydrate with Enteric Coated Granules of Lactic Acid Bacillus

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI: Access: Open Access Read More

Formulation and Evaluation of Tolperisone Hydrochloride Sustained Release Tablet

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI: Access: Open Access Read More

Sensitive Visible Spectrophotometric methods Development for Estimation of Sapropterin Dihydrochloride in tablet dosage form

Author(s): U. Viplava Prasad, M. Syam Bab, B. Kalyana Ramu

DOI: 10.5958/0975-4377.2017.00007.6 Access: Open Access Read More

Co-Processed Excipients for Tabletting

Author(s): P. Lekshmi, K. Pramod, K.C. Ajithkumar

DOI: 10.5958/0975-4377.2016.00007.0 Access: Open Access Read More

Design, Development and Evaluation of Pulsatile Drug Delivery System of Ramipril

Author(s): AL. Akilandeshwari , K. Elango, S. Daisy Chellakumari, S. Kishore Kumar

DOI: Access: Open Access Read More

Formulation and Evaluation of Mycophenolate mofetil Capsules

Author(s): Akelesh T., R. Ramya, Venkatesh. P., Divya Jacob , R. Venkatnarayanan

DOI: Access: Open Access Read More

Formulation and Evaluation of Modified Pulsincap Drug Delivery System for Chronotherapeutic Delivery of Montelukast Sodium

Author(s): V. Kalyani, K. Basanthi , T.E.G.K. Murthy

DOI: Access: Open Access Read More

Microencapsulation- An Overeview

Author(s): M.S. Gambhire, S. Lilke , V.M. Gambhire

DOI: Access: Open Access Read More

Fast Dissolving Tablets-An Updated Review

Author(s): Ashok Thulluru, K. Saravanakumar, Ch. S. Phani Kumar, Nawaz Mahammed, D. Sreeja, G. Bhuvanesh, N. Vamsi Chowdary, Nayeema Khowser Shaik

DOI: 10.5958/0975-4377.2019.00049.1 Access: Open Access Read More

Comparative in Vitro Dissolution Assessment of Three Different Brands of Lansoprazole Capsules

Author(s): J. Srinivasa Rao, J. Naga Mallika, M. Sri Madhu Sri, G. Raveendra Babu, M. Prasada Rao, C. Gopinath

DOI: Access: Open Access Read More

Spectrophotometric and Potentiometric Determination of Some Organophosphorus Pesticides in Bulk Powder and in their Dosage Forms

Author(s): Abd El-Aziz B. Abd El-Aleem, Mamdouh R. Rezk, Shaban M. Khalile, Omneya K. El-Naggar

DOI: 10.5958/0975-4377.2017.00011.8 Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377