Author(s): Swati B. Rathod, Poonam A. Salunke, Vaishali C. Kulkarni, Bhavika R. Chavhan, Shashikant D. Barhate

Email(s): srathod251@gmail.com

DOI: 10.5958/0975-4377.2018.00027.7   

Address: Swati B. Rathod*, Poonam A. Salunke, Vaishali C. Kulkarni, Bhavika R. Chavhan, Dr. Shashikant D. Barhate
Shree Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner–424206.
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2018


ABSTRACT:
New, simple and rapid method indicating UV–Visible spectroscopy was developed and validated for the estimation of Indomethacin in pure form, and in formulation. Mix hydrotropic solution was used as a solvent. The adequate drug solubility and maximum assay sensitivity (320 nm) in the wavelength range of (200-400 nm), the linear calibration curve was obeyed in the concentration range of (10-50 µg/ml) show regression equation (Y=0.015X-0.002), and correlation Coefficient (R2=0.998). This method was validated and applied to the determination of Indomethacin capsules form, no interference was found from capsule excipients at the selected wavelength and analysis conditions. It was concluded that the developed method is accurate, sensitive, precise, and reproducible and indirectly for the estimation of Indomethacin content in pharmaceutical formulation.


Cite this article:
Swati B. Rathod, Poonam A. Salunke, Vaishali C. Kulkarni, Bhavika R. Chavhan, Shashikant D. Barhate. Method Development and Validation of Indomethacin in Bulk Drug and Capsule Formulation by using Mix Hydrotrophy. Res. J. Pharma. Dosage Forms and Tech.2018; 10(3): 175-178. doi: 10.5958/0975-4377.2018.00027.7


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DOI: 10.5958/0975-4377 


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