Shamal Satish Patil, Rajendra K. Surawase, Parag D. Kothawade
Shamal Satish Patil*, Rajendra K. Surawase, Parag D. Kothawade
Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Manur, Nashik 423501, Maharashtra, India.
Volume - 15,
Issue - 4,
Year - 2023
Purpose – There are several approaches that have been developed in order to increase the gastric residence time (GRT) floating drug delivery system is one of them. Floating microspheres improve the bioavailability and releasing for long period of time. In the current investigation curcumin floating microspheres are being developed to extend the drug release. Method - Emulsion solvent evaporation approach is used for development of floating microspheres by using Eudragit RS100, HPMC K100, Ethyl Cellulose as polymers. Acetone and Ethanol was used as a solvent in a ratio of 10:5. Stirring speed of mechanical stirrer was 900rpm. Result - There was no reaction between the drug and excipients according to FTIR analysis. The developed microspheres have virtually spherical shapes and particle size range was between 200 - 420µm. The effectiveness of the drug entrapment was found between 60 - 98.4%. It was found that the buoyancy was between 70 - 92%. The in-vitro drug release was found to be 99.5 of batch 15. The developed microspheres indicated prolonged drug release of 12hrs. The optimized batch was B15. Conclusion - According to results of the research, developing gastro-retentive floating microspheres of curcumin using the emulsion solvent evaporation method with HPMC K100, Eudragit RS100, and ethyl cellulose is a promising method.
Cite this article:
Shamal Satish Patil, Rajendra K. Surawase, Parag D. Kothawade. Formulation Development and Evaluation of Floating Microspheres of Curcumin. Research Journal of Pharmaceutical Dosage Forms and Technology2023; 15(4):275-0. doi: 10.52711/0975-4377.2023.00044
Shamal Satish Patil, Rajendra K. Surawase, Parag D. Kothawade. Formulation Development and Evaluation of Floating Microspheres of Curcumin. Research Journal of Pharmaceutical Dosage Forms and Technology2023; 15(4):275-0. doi: 10.52711/0975-4377.2023.00044 Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-4-9
1. Patil C, Baklilwal S, Rane B, Gujrathi N, Pawar S. Floating microspheres: A promising approach for gastric retention. International Journal of Pharma Research and Developments. 2011; 2:12.
2. Srivastava AK, Ridhurkar DN, Wadhwa S. Floating microspheres of cimetidine: Formulation, characterization and in vitro evaluation. Acta Pharmaceutica. 2005; 55(3): 277-85.
3. Taneja R, Kataria MK, Bilandi A, Gupta A, Gedar S. Floating microsphere: a potential gastroretentive drug delivery system. Pharmacie Globale. 2013: 1; 4(4):1.
4. Chainesh S, Chitan A, Vinod R. An Overview on Gastroretentive Floating microspheres. International Journal. 2012; 2(2): 01-8.
5. Jain AK, Jain CP, Tanwar YS, Naruka PS. Formulation, characterization and in vitro evaluation of floating microspheres of famotidine as a gastro retentive dosage form. Asian Journal of Pharmaceutics (AJP). 2009; 3(3).
6. Kotha RR, Luthria DL. Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules. 2019; 24(16): 2930.
7. Allegra A, Innao V, Russo S, Gerace D, Alonci A, Musolino C. Anticancer activity of curcumin and its analogues: preclinical and clinical studies. Cancer Investigation. 2017: 2; 35(1):1-22.
8. Kumar K, Rai AK. Development and evaluation of floating microspheres of curcumin. Tropical Journal of Pharmaceutical Research. 2012; 11(5):713-9.
9. Kadam PV, Yadav KN, Bhingare CL, Patil MJ. Standardization and quantification of curcumin from Curcuma longa extract using UV visible spectroscopy and HPLC. Journal of Pharmacognosy and Phytochemistry. 2018; 7(5):1913-8.
10. Arumugam KA, Borawake PD, Shinde JV. Formulation and evaluation of floating microspheres of ciprofloxacin by solvent evaporation method using different polymers. International Journal of Pharmacy and Pharmaceutical Sciences. 2021; 13(7):101-8.
11. Karosiya SR, Vaidya VM, Bhajipale NS, Radke RS. Formulation and Evaluation of Gastroretentive Floating Microspheres loaded with Lamivudine. Journal of Drug Delivery and Therapeutics. 2022; 12(4-S):17-22.
12. Goyal P, Gill S, Gupta UD, Rath G, Narang RK, Goyal AK. Development and characterization of rifampicin loaded floating microspheres. Artificial Cells, Blood Substitutes, and Biotechnology. 2011; 39(5):330-4.
13. Sachan AK, Singh S, Kumari K, Devi P. Floating Microsphere of Curcumin as Targeted Gastro-retentive Drug Delivery System. Research Journal of Pharmacy and Technology. 2021; 14(10): 5202-6.
14. Vaseeha Banu T. S1, Mohammad Sameer Ansari, Mohamed Khaleel. Development and Evaluation of Metoclopramide Hydrochloride Floating Microspheres for controlled Release. Res. J. Pharma. Dosage Forms and Tech. 2019; 11(3):173-177.
15. Tirnja Rahangdale, Naveen Gupta, Neeraj Sharma, Ankita Shukla. In vitro Evaluation of Floating Microspheres of Gabapentin by Solvent Evaporation Method. Research Journal of Pharmaceutical Dosage Forms and Technology. 2022; 14(2):145-9.
16. Kumar Darapu B.N., K. Sundaramoorthy, T. Vetrichelvan. Formulation and In-Vitro Evaluation of Gastroretentive Floating Microspheres of Ranitidine Hydrochloride. Research J. Pharma. Dosage Forms and Tech. 2011; 3(1): 24-29.
17. P. Dinesh Kumar, L. Lakshman, Ch. V Alekhya, B. Vijay Babu. Formulation and Characterization of Lansoprazole Floating Microspheres. Research J. Pharma. Dosage Forms and Tech. 2012; 4(2): 128-132.