Author(s): Rajashri Shinde, Dhanshri Dhanbhar, Nikita Narad, Shivani Khandagale

Email(s): officialrajashrishinde@gmail.com

DOI: 10.52711/0975-4377.2023.00048   

Address: Rajashri Shinde, Dhanshri Dhanbhar, Nikita Narad, Shivani Khandagale
Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444602.
*Corresponding Author

Published In:   Volume - 15,      Issue - 4,     Year - 2023


ABSTRACT:
An innovative method to increase the solubility of water insoluble drug by using Nanocrystallization. Various factor like solubility, dissolution drug release, temperature, ph, have its effect on these process. Solubility is the ability of a substance, the solute, to form a solution with another substance, the solvent. Solutes are classified as highly soluble, sparingly soluble, or insoluble based on the concentration. Dissolution is ability of molecule to get break down in it. There are seven different types of dissolution apparatus defined in the United States Pharmacopeia (USP)-basket type, paddle type, reciprocating cylinder, and flow through cell, paddle over disc, rotating cylinder, and reciprocating disc. Drug release is when drug solutes migrate from the initial position in the polymeric system to the polymer's outer surface and then to the release medium. It is directly related to the drug stability. There are many mechanisms by which the drug release can be controlled in a system: dissolution, diffusion, osmosis, partitioning, swelling, erosion, and targeting. Drug Stabilizers are compounds, usually polysaccharides, which are added to products to provide and preserve structure, stability, and viscosity. Broadly there are 3 methods for the nanocrystallizationi.e. Bottom up technique, Top down technique and combination technique.


Cite this article:
Rajashri Shinde, Dhanshri Dhanbhar, Nikita Narad, Shivani Khandagale. Nanocrystallization - A Tool for Enhancement of Solubility and Dissolution Rate for Water Insoluble Drugs. Research Journal of Pharmaceutical Dosage Forms and Technology2023; 15(4):303-0. doi: 10.52711/0975-4377.2023.00048

Cite(Electronic):
Rajashri Shinde, Dhanshri Dhanbhar, Nikita Narad, Shivani Khandagale. Nanocrystallization - A Tool for Enhancement of Solubility and Dissolution Rate for Water Insoluble Drugs. Research Journal of Pharmaceutical Dosage Forms and Technology2023; 15(4):303-0. doi: 10.52711/0975-4377.2023.00048   Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-4-13


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