ABSTRACT:
A novel compression of coated pellets formulation of captopril was developed in order to improve the efficacy of antihypertensive therapy considering the half-life of drug. The sustained release pellets containing tablet were prepared by using 32 factorial design by employing 2 polymers i.e., HPMC k4M and eudragit RS 30D at 3 levels. As captopril having short half-life (2 hrs) there is need to formulate the modified release formulation. sustained release pellets containing tablet is the best approach to reduce the dose frequency of captopril tablet, by using the single polymer (eudragit RS 30D). The release retardant layer over a drug loaded pellets was achieved by 3% eudragit RS 30D polymer solution by using fluidized bed processor and then the pellets were mixed with other excipients and compress into the tablets and it showed the good sustained release pattern.
Cite this article:
Ujwala N. Pagar, Rajendra K. Surawase. Formulation and Evaluation of Captopril Sustained Release Pellet Containing Tablet by Fluidized Bed Processing. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(1):33-8. doi: 10.52711/0975-4377.2022.00006
Cite(Electronic):
Ujwala N. Pagar, Rajendra K. Surawase. Formulation and Evaluation of Captopril Sustained Release Pellet Containing Tablet by Fluidized Bed Processing. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(1):33-8. doi: 10.52711/0975-4377.2022.00006 Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-1-6
REFERENCE:
1. Chaudhari UR., Review of Captopril Drug Formulation, Mechanism of action, Dosage, Use and Adverse drug reaction. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(2):157-0.
2. Sahar A., Gholamhossein Y., Formulation and Invitro Evaluation of Fast-Disintegrating Sustained Dual Release Bucoadhesive Bilayer Tablet of Captopril for Treatment of Hypertension Crises. Research in Pharmaceutical Sciences. 2016; 11(4): 274-283.
3. Jha MK., Modified Releas Formulations to the Achieve the Quality Target Product Profile. International journal of Pharmacutoical Science and Research. 2012; 3(8): 2376-2386.
4. Zhen Y., Jiankun Y., A Method for Preparation of Sustained Release-Coated Metoprolol Succinate Pellet Containing Tablets. Pharmacutical Development and Technology. 2016; 21(8): 943-950.
5. Wagh RA., Surawase RK., Formulation and Development of Sustained Release Pellets of Nifedipine by Fluidized Bed Processor. Research Journal of Pharmacy and Technology. 2020; 13(4):1757-1761.
6. Diggikar SS., Nandgude TD., Formulation Modified Release Pellets of Montelukast Sodium. Research Journal of Pharmacy and Technology. 2018; 11(1):31-37.
7. Jaiswal H., Ansari VA., Pulsatile Drug Delivery System: An Overview with Special Emphasis on Losartan and Captopril. Research Journal of Pharmacy and Technology. 2019; 12(7):3175-3188.
8. Nagasamy VD., Meyynatham SN., Formulation and Evaluation Sustained Release Tablets of Ramipril. Research Journal of Pharmacy and Technology. 2020; 13(8):3873-3878.
9. Mohammed AH., Sravan k., Formulation and Evaluation Sustained Release Matrix Tablets of Acyclovir. Research Journal of Pharmacy and Technology. 2014; 7(3):290¬-295.
10. Mewada A., Shah S., Enhancement of Solubility and Dissolution Rate of Pravastatin using Solid Dispersion. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(2):89-4.
11. Khan H., Formulation and Invitro Evaluation Sustained Release Matrix Tablets of Valsartan using Beta-Cyclodextrin. Research Journal of Pharmaceutical Dosage Forms and Technology. 2020; 12(4):245-248.
12. Akilandeshwari AL., Elango K., Design, Development and Evaluation of Pulsatile Drug Delivery System of Ramipril. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014; 6(4):235-242.
13. Saujanya B., Pavani PG., Studies on Influence of Process and formulation Variables on Performance of Omeprazole Pellets. Research Journal of Pharmaceutical Dosage Forms and Technology. 2015; 7(1):21-29.
14. Chinmaya KS., Surepalli RM., Advances In Granulation Technology. Research Journal of Pharmacy and Technology. 2016; 9(5):571-580.
15. Sapkal SR., Jaiswal SB., Pellets as Controlled Release Drug Delivery System: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009; 1(3):179-183.
16. Singh HN., Saxena S., Pulsatile Drug Delivery System: Drugs used in the Pulsatile Formulations. Research Journal of Pharmaceutical Dosage Forms and Technology. 2013; 5(3): 115-121.
17. Sirisha PL., Conceptuation, Formulation and Evaluation of Sustained Release Floating Tablet of Captopril Compression Coated with Gastric Dispersible Hydrochlorothiazide using factorial Design. Int J Pharm Investig. 2014; 4(2):77¬-87.
18. Yasir A., Nisar R., Sustained Release of Captopril from Matrix Tablet using Methylcellulose in a New Derivative Form. Latin American Journal of Pharmacy. 2011; 30(9):1996-1701.