Author(s): Ujwala N. Pagar, Rajendra K. Surawase

Email(s): Email ID Not Available

DOI: 10.52711/0975-4377.2022.00006   

Address: Ujwala N. Pagar*, Rajendra K. Surawase Department of Pharmaceutics, Loknete Dr. J. D. Pawar College of Pharmacy, Kalwan 423501, Dist- Nashik, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2022


ABSTRACT:
A novel compression of coated pellets formulation of captopril was developed in order to improve the efficacy of antihypertensive therapy considering the half-life of drug. The sustained release pellets containing tablet were prepared by using 32 factorial design by employing 2 polymers i.e., HPMC k4M and eudragit RS 30D at 3 levels. As captopril having short half-life (2 hrs) there is need to formulate the modified release formulation. sustained release pellets containing tablet is the best approach to reduce the dose frequency of captopril tablet, by using the single polymer (eudragit RS 30D). The release retardant layer over a drug loaded pellets was achieved by 3% eudragit RS 30D polymer solution by using fluidized bed processor and then the pellets were mixed with other excipients and compress into the tablets and it showed the good sustained release pattern.


Cite this article:
Ujwala N. Pagar, Rajendra K. Surawase. Formulation and Evaluation of Captopril Sustained Release Pellet Containing Tablet by Fluidized Bed Processing. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(1):33-8. doi: 10.52711/0975-4377.2022.00006

Cite(Electronic):
Ujwala N. Pagar, Rajendra K. Surawase. Formulation and Evaluation of Captopril Sustained Release Pellet Containing Tablet by Fluidized Bed Processing. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(1):33-8. doi: 10.52711/0975-4377.2022.00006   Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-1-6


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