The objective of the present study was to design, development and evaluation antitussive herbal cough syrup because designing of oral herbal formulation is still a challenge in modern pharmaceutics and the syrup formulation presents many technical problems to the industrial pharmacist. Potential antitussive herbs were used for developing the herbal cough syrup. Decoction of plant Anisomeles indica, Leaves of Adhathoda vasika, stems of Glycyrrhiza glabra, fruits of Piper nigrum and plant of Mentha piperita was prepared. One part of decoction was mixed with five parts of simple syrup IP (1:5) to prepare formulation. The formulations were evaluated by morphological characters, physical parameters like PH, Specific gravity, viscosity etc. Herbal cough syrup was also subjected for the accelerated stability testing (AST) for the period of 72hours at accelerated temperature conditions. No marked changes were noticed in all the evaluated parameters during AST. The laboratory scale preparation of herbal Syrup may be used as a stable, liquid dosage form and the work done in stability testing may help in the progress of shelf-life determination studies. The presence study includes design, development and evaluation of Anisomeles indica herbal cough syrup first time.
Cite this article:
Yogesh V. Ushir, Kundan J. Tiwari. Design, Development and Evaluation of Anisomeles indica Herbal Cough Syrup. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(4):292-6. doi: 10.52711/0975-4377.2021.00048
Yogesh V. Ushir, Kundan J. Tiwari. Design, Development and Evaluation of Anisomeles indica Herbal Cough Syrup. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(4):292-6. doi: 10.52711/0975-4377.2021.00048 Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-4-5
1. Anonymous, (2020). https://www.thekitchn.com/how-to-make-simple-syrup-240337; retrieved on 25/02/2020.
2. Anu, K., (2016). Formulation and evaluation of herbal cough syrup, European Journal of Pharmaceutical and Medical Research, 3(5): 517-522. https://storage.googleapis.com/journal-uploads/ejpmr/article_issue/1482382005.pdf.
3. AOAC, (2000). Official Methods of Analysis of AOAC International. Maryland: USA.
4. Ashvini, R.P. and Ravindra, P. (2019). Formulation and evaluation of Hyptis suaveolens herbal syrup, American Journal of Pharmtech Research. 09(06): 284-287. http://ajptr.com/ assets/upload/publish_article/AJPTR_960251.pdf.
5. Asolkar, LV., Kakkar and Chakre. (1965-1981), Glossary of Indian Medicinal Plants with Active Principles. New Delhi.
6. Batish, D.R., Kaur, M., Singh, H.P. and Kohli, R.K. (2007). Phytotoxicity of a medicinal plant, Anisomeles indica, against Phalaris minor and its potential use as natural herbicide in wheat fields. Crop Protection, 26: 948–952.
7. Chaterjee, A. (1997). The Treatise of Indian Medicinal Plants. New Delhi.
8. Chopra, R.N., Nayar, S.L. and Chopra, I.C. (1986). Glossary of Indian Medicinal Plants, New Delhi.
9. Chopra, R.N. (1956). Glossary of Indian Medicinal Plants. New Delhi.
10. Khandelwal, K.R. (2005). Practical Pharmacognosy techniques and experiments. Pune.
11. Kokate, C.K. Handbook of Practical Pharmacognosy. New Delhi.
12. Kumar, S.P. and Nayak, D,P. (2019). Development and evaluation of poly herbal syrup from some herbs used as expectorant. World Journal of Pharmacy and Pharmaceutical Sciences. 2 (5): 3848-3853.
13. Lachman, L., Lieberman, H.A. and Kanig JL. The Theory and Practice of Industrial Pharmacy. Bombay.
14. Nadkarni, A.K. (2009). Dr. K. M. Nadkarni’s; Indian Materia Medica. Bombay.
15. Rao, Y.K., Shih-Hua, F., Shih-Chuan, H., Tsung-Hsien, Y. and Yew-M.T. (2009). The constituents of Anisomeles indica and their anti-inflammatory activities. Journal of Ethnopharmacology. 121: 292–296.
16. Rastogi, R. and, Malhotra, B.N. (2001). Compendium of Indian Medicinal Plants, Lucknow.
17. Sadia shakeel, Zeeshan Ahmed Shaikh, Syed Faisal Zaidi, Khan Usmanghani. Development and evaluation of polyherbal Entoban syrup, Spatula DD, 2015; 5(2):97-102. DOI: 10.5455/spatula.20151001032308
18. The Wealth of India. (1985). A Dictionary of India Raw Material and Industrial Product; ‘The Wealth of India’. Council of Industrial and Scientific Research, New Delhi, Vol.- I(A): 277-278.
19. Ushir, Y.V. and Patel, K.N. (2011). Chemical Composition and Antibacterial Activity of Essential Oil from Anisomeles Species grown in India. Pharmacognosy Journal. 2 (18) 55-59. https://doi.org/10.1016/S0975-3575(11)80026-X
20. Ushir, Y.V., Patel, K.N. and Sheth N.R. (2011). Analysis of Fatty Acid in Anisomeles Species by Gas Chromatography-Mass Spectrometry. Pharmacognosy Journal. 2011, 3(22), 44-47. DOI: 10.5530/pj.2011.22.9
21. Y., Bhagyasri, K., Sai Priyanka, Suman Vadithya and N Siva Subramanian. (2018). Formulation and evaluation of polyherbal syrup for antidiabetic syrup. International Journal of Research in Pharmacy and Pharmaceutical Sciences. (1); 223-227.