Akhlaq Mustafa, Umar Hussain, Anas Iqbal Alvi, Ghazala Javed, Asim Ali Khan
Akhlaq Mustafa1*, Umar Hussain2, Anas Iqbal Alvi3, Ghazala Javed4, Asim Ali Khan5
1Research Officer (Chemistry), Drug Standardization Research Unit, Central Council for Research in Unani Medicine, Janakpuri, New Delhi
2Senior Research Fellows (SRF), Drug Standardization Research Unit, Central Council for Research in Unani Medicine, Janakpuri, New Delhi.
3Research Assistant (Chemistry), Drug Standardization Research Unit, Central Council for Research in Unani Medicine, New Delhi.
4Research Officer Incharge (Unani), Central Council for Research in Unani, Medicine, 61-65, Institutional Area, Janakpuri, New Delhi.
5Director General, Central Council for Research in Unani Medicine, 61-65, Institutional Area, Janakpuri, New Delhi.
Volume - 15,
Issue - 1,
Year - 2023
Unani system of medicines classifies its formulation into several classes e. g. Huboob, Sufoof, Qurs, Sufoofs, Majoon, Arq, Roughan, Kushta etc. Among the various dosage forms of Unani system of medicine Sharbat Toot Siyah is one of the renowned formulations whichis widely used for the number of ailments e.g. Pharyngeal pain and sore throat. The drug Sharbat Toot Siyah was in-house manufactured in three batches of different volumes of 500, 600 and 700ml following the SOP guidelines and underwent for the evaluation of secondary metabolite constituents Profile with Physico-chemical Standardization of this important poly-herbal formulation. The present work contributes to the development of standardization parameters of herbal drugs used in Indian system of medicine like morphological properties, viscosity, pH values, ash values, extractive values, alcohol soluble matter, specific gravity at 25ºC, refractive index, sugar quantity e. g. total sugar, reducing sugar and non-reducing sugar, qualitative and quantitative inorganic elements, phyto-constituents and thin layer chromatography. In preliminary phytochemical investigation, analysis showed the presence of organic constituent’s amino acids, tannins, phyto-sterols, flavanoids and glycosides in the extract while in the elemental analysis, calcium, magnesium, phosphorous etc. were found to be present. The study also includes quality control parameters e. g. aflatoxins, microbial load, pesticide residue and detection of heavy metals which are helpful to ensure the purity, safety and efficacy of herbal formulation. The results so obtained for the various Physico-chemical tests may be taken as standard values for future reference.
Cite this article:
Akhlaq Mustafa, Umar Hussain, Anas Iqbal Alvi, Ghazala Javed, Asim Ali Khan. Studies Leading to Phyto and Physico-chemical Evaluation of an important Polypharmaceutical preparation (Syrup) "Sharbat Toot Siyah"- A Drug of Choice. Research Journal of Pharmaceutical Dosage Forms and Technology.2023; 15(1):14-8. doi: 10.52711/0975-4377.2023.00003
Akhlaq Mustafa, Umar Hussain, Anas Iqbal Alvi, Ghazala Javed, Asim Ali Khan. Studies Leading to Phyto and Physico-chemical Evaluation of an important Polypharmaceutical preparation (Syrup) "Sharbat Toot Siyah"- A Drug of Choice. Research Journal of Pharmaceutical Dosage Forms and Technology.2023; 15(1):14-8. doi: 10.52711/0975-4377.2023.00003 Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-1-3
1. Said M. Hamdard pharmacopoeia of eastern medicine. Delhi: Sri Satguru Publications; p 169, 1997.
2. Jurjani Ismail. Zakheera Khawarzamshahi. Vol. VIII, New Delhi: Idara Kitabu hifa, Pp. 19 2010
3. Department of AYUSH. National Formulary of Unani Medicine. Part-I. New Delhi: Ministry of Health and Family Welfare, Govt of India pp 221-224, 331-334 2006.
4. Department of AYUSH. Al-Qarabadeen. 2nd ed. New Delhi: CCRUM, pp 603-604, 649 2006.
5. Kabeeruddin, M. Bayazkabeer Part 3. New Delhi: Idara Kitabush Shifa, pp 71-77, 2010.
6. Department of AYUSH. Qarabadeen Majeedi. Delhi: All India Tibbi Conference, p 196, 1986.
7. Abdul Hafeez; Qarabadeen Jadeedi ;. New Delhi: CCRUM, pp 119-131, 2005.
8. Williams L, Wilkins. Remington-The science and practice of pharmacy. Vol. I, 21st Ed. New Delhi: Wolters Kluwer Health Pvt. Ltd, p 754, 298, 2006.
9. Department of Ayush, National Formulary of Unani Medicine, Part-1, M/O Health & F. W. Govt. of India, PP 224.
10. Elmacı, Y., Altuğ, T., 2002. Flavour evaluation of three black mulberry (Morus nigra) cultivars using GC/MS, chemical and sensory data. J. Sci. Food Agric., 82(6):632-635. [doi:10.1002/jsfa.1085]
11. Darias-Martin, J., Lobo-Rodrigo, G., Hernandez-Cordero, J., Diaz-Diaz, E., Diaz-Romero, C., 2003. Alcoholic beverages obtained from black mulberry. Food Technol. Biotechnol., 41(2):173-176. Duke, J. A., Ayensu, E. S., 1985. Medicinal Plants of China, Reference Publications Inc., Algonac, MI.
12. Arabshahi-Delouee, S., Urooj, A., 2007. Antioxidant properties of various solvent extracts of mulberry (Morus indica L.) leaves, Food Chem., 102(4):1233-1240.[doi:10.1016/ j.foodchem.2006.07.013]
13. Ercisli, S., Orhan, E., 2007. Chemical composition of white (Morus alba), red (Morus rubra) and black (M. nigra) mulberry fruits. Food Chem., 103(4):1380-1384. [doi:10. 1016/j. foodchem.2006.10.054]
14. Chu, Q.; Lin, M.; Tian, X.; Ye, J. Study on capillary electrophoresis-amperometric detection profiles of different parts of Morus alba L. J. Chromatogr. A 2006, 1116, 286–290.
15. Anonymous, 1998, Quality Control methods for medicinal plant materials, World Health organization, Geneva, Pp. 25-28.
16. Trease, G. E. and Evans, W. C., 1983: Pharmacognosy, 10 th Edition, BailliereTindel, London.
17. Stahl., 1969, Thin layer Chromatography: A laboratory hand book, Springer Verlag, Berlin, pp. 52-86, 127-128, 900
18. Harborne, J.B., 1973. Phytochemical Methods, Chapman and Hall, London, P. 70.
19. Wagner, H. Bladt, S., 1984, Plant Drug Analysis,: A Thin Layer Chromatography Atlas (2 nd Edition) Springer-Verlag, Germany.
20. Anonymous, 2000 Association of Official Analytical Chemists (AOAC), 17th. Edition
21. Anonymous, 1992, Standardization of Single Drugs of Unani Medicine, part II, CCRUM, M/O Health and F. W, New Delhi, pp 201.