Author(s):
Kaustubh Gavali, Prathmesh Kulkarni, Ashwini Patil, Prajkta Ghagare, Shrikant Magdum
Email(s):
gavalikaustubh4@gmail.com
DOI:
10.5958/0975-4377.2021.00007.0 
Address:
Kaustubh Gavali*, Prathmesh Kulkarni, Ashwini Patil, Prajkta Ghagare, Shrikant Magdum
Department of Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli, Dist-Sangli, Maharashtra. India – 416416.
*Corresponding Author
Published In:
Volume - 13,
Issue - 1,
Year - 2021
ABSTRACT:
Nipah is a viral infection from the zoonotic virus transmitted through contaminated food or directly contact between infected people. The natural host of virus is fruit bats of the Pteropodidae Family, Pteropus genus. Although nipah has very less known outbreaks in asia but fatality rate is 40% to 75%. This rate can vary depending on local capabilities for epidemiological surveillance and clinical management. The signs and symptoms of infection ranges from asymptomatic infection to acuate respiratory infection and fatal encephalitis. The incubation period is in the range of 4 to 14 days but it might be as long as 45 days as reported. The diagnosis can be done by clinical history during the acuate and convalescent phase of the disease. The main test used for diagnosis include polymerase chain reaction (RT-PCR) from body fluids and antibody detection via enzyme linked immune sorbent assay (ELISA). There are no currently treatment for infection (no specific drug or vaccine). The primary treatment for human is supportive care.
Cite this article:
Kaustubh Gavali, Prathmesh Kulkarni, Ashwini Patil, Prajkta Ghagare, Shrikant Magdum. A Review on an insight into the Nipah virus infection in human. Res. J. Pharma. Dosage Forms and Tech.2021; 13(1):31-40. doi: 10.5958/0975-4377.2021.00007.0
Cite(Electronic):
Kaustubh Gavali, Prathmesh Kulkarni, Ashwini Patil, Prajkta Ghagare, Shrikant Magdum. A Review on an insight into the Nipah virus infection in human. Res. J. Pharma. Dosage Forms and Tech.2021; 13(1):31-40. doi: 10.5958/0975-4377.2021.00007.0 Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-1-7
REFERENCE:
1. BS Web Team. (2018)
2. https://timesofindia.indiatimes.com/city/kozhikode/keralarecord.
3. MMWR. Outbreak of Hendra-like virus-Malaysia & Singapore 1998–1999.Morb Mortal Weekly Report.1999; 48: 265–269.
4. World Health Organization Nipah virus outbreaks in the WHO South-East Asia Region, Communicable Diseases Department, Disease Surveillance and Epidemiology. Update 1 May 2012.
5. Drexler JF, Corman VM, Gloza-Rausch F, Seebens A, Annan A, Ipsen A, Kruppa T, Mu¨ller MA, Kalko EK, Adu-Sarkodie Y, Oppong S, Drosten C. Henipavirus RNA in African bats. PLoS ONE. 2009;4(7):63-67.
6. Hsu VP, Hossain MH, Parashar UD, Ali MM, Ksiazek TG, Kuzmin I, Niezgoda M, Rupprecht C, Bresee J, Breiman RF. Nipah virus encephalitis reemergence, Bangladesh. Emerg Infect Dis. 2004;10: 2082–7.
7. Institute of Epidemiology, Disease Control and Research (IEDCR). Nipah Infection in 2013—Update on 5 Feb, 2013.
8. International Centre for Diarrheal Disease Research, Bangladesh (ICDDRB). Nipah outbreak in Faridpur District, Bangladesh.Health Sci Bull. 2010;8: 6–11.
9. World Health Organization Global Early Warning System for Major Animal Diseases, including Zoonoses. Zoonoses& Vet Pub Hlth. 2007.
10. International Centre for Diarrheal Disease Research, Bangladesh (ICDDRB). Person-to-person transmission of Nipah virus during outbreak in Faridpur District.Health Sci Bull. 2004; 2:5–9.
11. Nipah virus outbreak in kerala: Times now digital. may 23.2018.www.timesnownews.com › Health.
12. Arankalle VA, Bandyopadhyay BT, Ramdasi AY, Jadi R, Patil DR, Rahman M, Majumdar M, Banerjee PS, Hati AK, Goswami RP, Neogi DK, Mishra AC. Genomic characterization of Nipah virus, West Bengal, India. Emerg Infect Dis. 2011;17: 907–9.
13. Institute of Epidemiology, Disease Control and Research (IEDCR). Nipah Infection in 2013.
14. World Health Organization Global Early Warning System for Major Animal Diseases, including Zoonoses. Zoonoses& Vet Pub Hlth. 2007.
15. Chadha MS, Comer JA, Lowe L, Rota PA, Rollin PE, Bellini WJ, Ksiazek TG, Mishra A. Nipah virus-associated encephalitis outbreak, Siliguri, India. Emerg Infect Dis. 2006;12(2):235–40.
16. International Centre for Diarrheal Disease Research, Bangladesh (ICDDRB). Outbreaks of encephalitis due to Nipah/Hendra-like viruses. Western Bangladesh. Health Sci Bull. 2003; 1:1–9.
17. Neethu C. Sharma. What is Nipah virus and how is it transmitted? May 23 2018. 12.
18. WorldOrganisation for Animal Health (Office International des Épizooties: OIE) Nipah (virus encephalitis). Technical Disease Cards, OIE, Paris. (2009)
19. Chong HT, Tan CT, Goh KJ, et al Occupational exposure, age, diabetes mellitus and out come of acute Nipah encephalitis. Neurol J Southeast Asia (2001) 6:7
20. Tan CT, Goh KJ, Wong KT, et al. Relapse and late-onset Nipah encephalitis. Ann Neuro (2002) l51:703
21. Wong KT, Shieh WJ, Kumar S, et al (in press) Nipah virus infection: Pathology and pathogenesis of an emerging paramyxoviral zoonosis. Confirmed to be accepted for publication by the American J of Pathology.
22. Griffin DE, Bellini WJ Measles virus. In: Fields B et al (eds) Field’s virology. Lippincott-Raven, Philadelphia, pp 1267–131244. (1996) Sarji SA, Abdullah BJJ, Goh KJ, et al Magnetic resonance imaging features of Nipah encephalitis. AJR (2000) 175:437.
23. Wahed F, Kader SA, Akhtarunnessa, Mahamud MM Nipah Virus: An Emergent Deadly Paramyxovirus Infection In Bangladesh. J Bangladesh Soc Physiol. (2011) 6: 134-139.
24. Chong HT, Tan CT. Relapsed and late-onset Nipah encephalitis, a report of three cases. Neurol J Southeast Asia (2003) 8: 109-112.
25. Uppal PK, Emergence of Nipah virus in Malaysia. Ann N Y Acad Sci (2000) 916: 354-357.
26. World Organisation for Animal Health (Office International des Épizooties: OIE) Nipah (virus encephalitis). Technical Disease Cards, OIE, (2009) Paris.
27. Mohd Nor MN, Gan CH, Ong BL Nipah virus infection of pigs in peninsular Malaysia. Rev Sci Tech (2000) 19: 160-165.
28. Middleton DJ, Westbury HA, Morrissy CJ, van der Heide BM, Russell GM, et al. Experimental Nipah virus infection in pigs and cats. J Comp Pathol (2002) 126: 124-136.
29. Tanimura N, Imada T, Kashiwazaki Y, Sharifah SH Distribution of viral antigens and development of lesions in chicken embryos inoculated with nipah virus. J Comp Pathol (2006) 135: 74-82.
30. Bossart KN, McEachern JA, Hickey AC, Choudhry V, Dimitrov DS, et al. Neutralization assays for differential henipavirus serology using Bio-Plex protein array systems. J Virol Methods (2007) 142: 29-40.
31. Middleton DJ, Westbury HA, Morrissy CJ, van der Heide BM, Russell GM, et al. Experimental Nipah virus infection in pigs and cats. J Comp Pathol (2002) 126: 124-136
32. Mungall BA, Middleton D, Crameri G, Bingham J, Halpin K, et al. Feline model of acute nipah virus infection and protection with a soluble glycoprotein-based subunit vaccine. J Virol (2006) 80: 12293-12302.
33. WorldOrganisation for Animal Health (Office International des Épizooties: OIE) Manual of Diagnostic Tests and Vaccines for Terrestrial Animals, OIE, Paris, Hendra and Nipah virus diseases, (2010) 2.9.(6). 3-9.
34. McEachern JA, Bingham J, Crameri G, Green DJ, Hancock TJ, Middleton D, et al. A recombinant subunit vaccine formulation protects against lethal Nipah virus challenge in cats. Vaccine. Volume 26, Issue 31, 2008:3842-3852.
35. Weingartl et al. Recombinant Nipah virus vaccines protect pigs against challenge. Journal of Virology 80, 2006: 7929-38.