Author(s): S. Shanmugam, T.R. Ramvignesh, K. Sundaramoorthy, T. Ayyappan, T. Vetrichelvan

Email(s): rampharma86@gmail.com

DOI: Not Available

Address: S. Shanmugam, T.R. Ramvignesh*, K. Sundaramoorthy, T. Ayyappan and T. Vetrichelvan
Adhiparasakthi College of Pharmacy, Melmaruvathur, Tamilnadu.
*Corresponding Author

Published In:   Volume - 3,      Issue - 2,     Year - 2011


ABSTRACT:
Aciclovir, an antiviral is effective against human Herpes Simplex viruses, commercially available as a 3 % w/w eye ointment to be applied 5 times a day in the eye. The poor therapeutic response exhibited by conventional ophthalmic ointments due to rapid precorneal elimination of the drug may be overcome by the use of an ocusert inserted in the cul-de-sac of lower eye lid. Inserts containing Aciclovir were prepared by using solvent casting method. Drug reservoir and rate controlling membrane were prepared using different hydrophilic and hydrophobic polymers respectively with Poly Ethylene Glycol 400 as the plasticizer. DSC and IR spectral studies were performed to confirm the interaction of drug and polymers in formulation. The ocuserts were evaluated for their physico chemical properties, mechanical properties and in-vitro release characteristics. A zero order release formulation VI was subjected to UV irradiation for sterilization. The developed formulation was stable, sterile and non-irritant


Cite this article:
S. Shanmugam, T.R. Ramvignesh, K. Sundaramoorthy, T. Ayyappan, T. Vetrichelvan. Design and Evaluation of Novel Ophthalmic Delivery System of Aciclovir for Herpes Simplex Infection. Research J. Pharma. Dosage Forms and Tech. 2011; 3(2): 53-57 .


Recomonded Articles:

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7         Access: Open Access Read More

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2         Access: Open Access Read More

Author(s): Swati S Talokar, Rohan R Vakhariya

DOI: 10.5958/0975-4377.2017.00001.5         Access: Open Access Read More

Author(s): Debjit Bhowmik, Amrendra Singh , Praveen Khirwadkar, Nishi Shukla, Vikas Kumar Chaudhari

DOI: 10.5958/0975-4377.2016.00027.6         Access: Open Access Read More

Author(s): Masheer Ahmed Khan

DOI:         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI:         Access: Open Access Read More

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5         Access: Open Access Read More

Author(s): Praveen Kumar Uppala, K. Atchuta Kumar, Murali Krishna, U. Upendra Rao

DOI: 10.5958/0975-4377.2016.00039.2         Access: Open Access Read More

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X         Access: Open Access Read More

Author(s): Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe

DOI:         Access: Open Access Read More

Author(s): Ashok A Hajare, Mahesh N Mali, Arun S Dange, Sushil M Sarvagod, Shweta V Patwardhan ,Sachin T Kurane

DOI:         Access: Open Access Read More

Author(s): P. Lekshmi, K. Pramod, K.C. Ajithkumar

DOI: 10.5958/0975-4377.2016.00007.0         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags