Author(s): Akshay R. Yadav, Shrinivas K. Mohite

Email(s): akshayyadav24197@gmail.com

DOI: 10.5958/0975-4377.2020.00035.X   

Address: Akshay R. Yadav*, Shrinivas K. Mohite
Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist- Sangli, Maharashtra, India- 415404.
*Corresponding Author

Published In:   Volume - 12,      Issue - 3,     Year - 2020


ABSTRACT:
Peptides and proteins have great therapeutic potential. Proteins and peptides may be administered for therapeutic effects at comparatively low doses because of their relatively specific mode of action. For several chronic conditions such as cancer, hepatitis, diabetes, rheumatoid arthritis and leukaemia, this potent therapy is indicated. While the peptide and protein therapeutic market has developed significantly over the past decades, their use has been limited by delivery. Most are currently delivered intravenously or subcutaneously due to degradation and limited absorption in the gastrointestinal tract, although oral delivery is preferred. In order to facilitate the oral peptide delivery, absorption enhancers, enzyme inhibitors, carrier systems and stability enhancers are therefore being studied. Additionally, the delivery of transdermal peptides avoids gastrointestinal tract problems but also faces absorption limitations. Injections (i.e. intravenous, intramuscular, or subcutaneous route) remain the most common means of administering these protein and peptide drugs until recently. The oral, buccal, intranasal, pulmonary, transdermal, ocular and rectal routes that have been tried with varying degrees of success. This review discusses oral and transdermal peptide drug delivery, focusing on barriers and solutions to absorption and recent advances are discussed.


Cite this article:
Akshay R. Yadav, Shrinivas K. Mohite. Recent Advances in Protein and Peptide Drug Delivery. Res. J. Pharma. Dosage Forms and Tech.2020; 12(3):205-212. doi: 10.5958/0975-4377.2020.00035.X

Cite(Electronic):
Akshay R. Yadav, Shrinivas K. Mohite. Recent Advances in Protein and Peptide Drug Delivery. Res. J. Pharma. Dosage Forms and Tech.2020; 12(3):205-212. doi: 10.5958/0975-4377.2020.00035.X   Available on: https://rjpdft.com/AbstractView.aspx?PID=2020-12-3-12


REFERENCES:
1. Bummer PM, Koppenol S. Chemical and physical considerations in protein and peptide stability; In: Protein Formulation and Delivery, Drugs and the Pharmaceutical Sciences. McNally EJ, Marcel Dekker. New York, 2000: 15-18.
2. Torchilin V. Intracellular delivery of protein and peptide therapeutics. Drug Discov. Today Technol. 2009; 5(2–3): e95–e103.
3. Maher S, Brayden D. Overcoming poor permeability: translating permeation enhancers for oral peptide delivery. Drug Discov. Today Technol. 2012; 9(2): e113–e119.
4. Hamman JH, Enslin GM, Kotze AF. Oral delivery of peptide drugs: barriers and developments. BioDrugs. 2005; 19(3): 165–177.
5. Shaji J, Patole V. Protein and Peptide drug delivery: oral approaches. Indian J. Pharm. Sci. 2008; 70(3): 269–277.
6. Mahato RI, Narang AS, Thoma L, Miller DD. Emerging trends in oral delivery of peptide and protein drugs. Crit. Rev. Ther. Drug Carrier Syst. 2003; 20(2–3): 153–214.
7. Fruton JS. A history of pepsin and related enzymes. Q. Rev. Biol. 2002; 77(2): 127–147.
8. Kourtesi C, Ball AR, Huang YY, et al. Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation. Open Microbiol. J. 2013; 7: 34–52.
9. Zhou SF. Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition. Xenobiotica. 2008; 38(7–8): 802–832.
10. Sharom FJ, Didiodato G, Yu X, Ashbourne KJ. Interaction of the P-glycoprotein multidrug transporter with peptides and ionophores. J. Biol. Chem. 1995; 270(17): 10334–10341.
11. Pond SM, Tozer TN. First-pass elimination. Basic concepts and clinical consequences. Clin. Pharmacokinet. 1984; 9(1): 1–25.
12. Buxton, I. Pharmacokinetics and pharmacodynamics: the dynamics of drug absorption, distribution, action, and elimination. In: Brunton, L.; Lazo, J.; Parker, K., editors. Goodman and Gilman's The Pharmacological Basis of Therapeutics. McGraw-Hill Medical Publishing Division; NY, USA: 2006: 1-40.
13. Mahalakshmi, R.; Balaram, P. The use of D-amino acids in peptide design.. In: Konno, R.; Brückner, H.; D'Aniello, A.; Fisher, GH.; Fujii, N.; Homma, H., editors. D-Amino Acids: A New Frontier in Amino Acid and Protein Research – Practical Methods and Protocols. Nova Biomedica Books; Hauppauge. 2007; 8(7): 415-430.
14. Kaminski, HJ. Myasthenia Gravis and Related Disorders. Vol. 393. Blackwell Publishing; NJ, USA: 2008. Cyclosporine is derived from a fungus and is a cyclic undecapeptide with actions directed exclusively on T cells, Rev. 2004; 23(4): 82-84.
15. Mcmartin C, Hutchinson LE, Hyde R, Peters GE. Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity. J. Pharm. Sci. 1987; 76(7): 535– 540.
16. Vlieghe P, Lisowski V, Martinez J, Khrestchatisky M. Synthetic therapeutic peptides: science and market. Drug Discov. Today. 2010; 15(1–2): 40–56.
17. Greenwald RB, Choe YH, Mcguire J, Conover CD. Effective drug delivery by PEGylated drug conjugates. Adv. Drug Deliv. Rev. 2003; 55(2): 217–250.
18. Pisal DS, Kosloski MP, Balu-Iyer SV. Delivery of therapeutic proteins. J. Pharm. Sci. 2010; 99(6): 2557–2575.
19. Veronese FM, Harris JM. Introduction and overview of peptide and protein pegylation. Adv. Drug Deliv. Rev. 2002; 54(4): 453–456.
20. Webster, R.; Elliot, V.; Park, B.; Walker, D.; Hankin, M.; Taupin, P. PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicals.. In: Veronese, F., editor. PEGylated Protein Drugs: Basic Science and Clinical Applications. Birkhauser; Basel, Switzerland: 2009: 127-146.
21. Basu A, Yang K, Wang M. Structure-function engineering of interferon-beta-1b for improving stability, solubility, potency, immunogenicity, and pharmacokinetic properties by siteselective mono-PEGylation. Bioconjug. Chem. 2006; 17(3): 618–630.
22. Leone-Bay A, Santiago N, Achan D. N-acylated a-amino acids as novel oral delivery agents for proteins. J. Med. Chem. 1995; 38(21): 4263–4269.
23. Kahns AH, Buur A, Bundgaard H. Prodrugs of peptides. 18. Synthesis and evaluation of various esters of desmopressin (dDAVP). Pharm. Res. 1993; 10(1): 68–74.
24. Cook CS, Karabatsos PJ, Schoenhard GL, Karim A. Species dependent esterase activities for hydrolysis of an anti-HIV prodrug glycovir and bioavailability of active SC-48334. Pharm. Res. 1995; 12(8): 1158–1164.
25. Fujii S, Yokoyama T, Ikegaya K, Sato F, Yokoo N. Promoting effect of the new chymotrypsin inhibitor FK-448 on the intestinal absorption of insulin in rats and dogs. J. Pharm. Pharmacol. 1985; 37(8): 545–549.
26. Ziv E, Lior O, Kidron M. Absorption of protein via the intestinal wall. A quantitative model. Biochem. Pharmacol. 1987; 36(7): 1035–1039.
27. Bernkop-Schnurch A. Chitosan and its derivatives: potential excipients for peroral peptide delivery systems. Int. J. Pharm. 2000; 194(1): 1–13.
28. Schipper NG, Varum KM, Artursson P. Chitosans as absorption enhancers for poorly absorbable drugs. 1: Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells. Pharm. Res. 1996; 13(11): 1686–1692.
29. Schipper NG, Varum KM, Stenberg P, Ocklind G, Lennernas H, Artursson P. Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement. Eur. J. Pharm. Sci. 1999; 8(4): 335–343.
30. Lindmark T, Nikkila T, Artursson P. Mechanisms of absorption enhancement by medium chain fatty acids in intestinal epithelial Caco-2 cell monolayers. J. Pharmacol. Exp. Ther. 1995; 275(2): 958–964.
31. Sawada T, Ogawa T, Tomita M, Hayashi M, Awazu S. Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate. Pharm. Res. 1991; 8(11): 1365–1371.
32.  Sharma J, Bansal P, Sanik A. Noninvasive routes of proteins and peptides drug delivery. Indian J. Pharm. Sci. 2011; 73(4): 367–375.

Recomonded Articles:

Author(s): Swati S Talokar, Rohan R Vakhariya

DOI: 10.5958/0975-4377.2017.00001.5         Access: Open Access Read More

Author(s): K Sonu Sharma, Rashmi Sharma, G Vidya Sagar

DOI:         Access: Open Access Read More

Author(s): Shoaib Ahmad

DOI: 10.5958/0975-4377.2016.00041.0         Access: Open Access Read More

Author(s): Suraj R. Wasankar, Kshitij V. Makeshwar, Abhishek D. Deshmukh, Rahul M. Burghate

DOI:         Access: Open Access Read More

Author(s): Baladaniya Manoj, Vadgama Neha, Patel Priya

DOI:         Access: Open Access Read More

Author(s): Chinmaya Keshari Sahoo, Surepalli Rammohan Rao, Muvvala Sudhakar, D. Venkata Ramana, Kanhu Charan Panda

DOI: 10.5958/0975-4377.2017.00024.6         Access: Open Access Read More

Author(s): SM Sarode, MK Kale, G Vidyasagar

DOI:         Access: Open Access Read More

Author(s): Priya Patel, Rohini Sahu, Renjil Joshi, Surabhi Armarkar,Tarannum Parveen, Narendra Pratap, Renuka Sahu, Pushpanjali Sahu, Dujram Sahu, Rupali Manikpuri, Madhav Patel, Tikeshwar Sahu, Bhupendra Rajak, Parmanand Sahu, Pooja Yadav, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00013.7         Access: Open Access Read More

Author(s): Anusha. V

DOI:         Access: Open Access Read More

Author(s): Pokhariyal Tarun, Singh Vikas Kumar, Tiwari Ajay Kumar

DOI:         Access: Open Access Read More

Author(s): A Chandy, Sudish Rai, A Manigauha, Suresh Sahu

DOI:         Access: Open Access Read More

Author(s): Kasani Harikrishna Gouda, V. Sai Kishore, N. Balaji, V. Vijaya Kumar, N. Raghuram

DOI:         Access: Open Access Read More

Author(s): N.K. Hada, Ashawat M.S.

DOI:         Access: Open Access Read More

Author(s): Vijaya Kumar V., Raghuram N., K. Hari Krishna, K. Rajyalakshmi, Y. Indira Muzib

DOI:         Access: Open Access Read More

Author(s): Rutuja K. More, Diksha S. Sonawane, Moreshwar P. Patil, Sanjay J. Kshirsagar

DOI: 10.5958/0975-4377.2018.00030.7         Access: Open Access Read More

Author(s): M. Sunitha Reddy, Sama Mallikarjun Reddy, A. Mahesh Chandra, B. Sai Santhosh, Ch. Surekha, K. Naveen

DOI:         Access: Open Access Read More

Author(s): Kumar Darapu B.N., K. Sundaramoorthy ,T. Vetrichelvan

DOI:         Access: Open Access Read More

Author(s): Namdeo G. Shinde, Nagesh H. Aloorkar, Ajit S. Kulkarni

DOI:         Access: Open Access Read More

Author(s): Nikhil Patel, Chetan Patel, Savan Vachhani, ST Prajapati , CN Patel

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags