Author(s): Ramu Samineni, Sumalatha. K, Dharani G, Rachana J, Anitha P, Manasa K

Email(s): samineni.ramu@gmail.com

DOI: 10.5958/0975-4377.2019.00026.0   

Address: Ramu Samineni*, Sumalatha. K, Dharani G, Rachana J, Anitha P, Manasa K
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A. Rangampet, Tirupati, AP-517102
*Corresponding Author

Published In:   Volume - 11,      Issue - 3,     Year - 2019


ABSTRACT:
The objective of the present study is to formulate and evaluate oral disintegrating tablets of Montelukast sodium and Desloratadine by direct compression using different concentrations of superdisintegrants like croscarmellose sodium, sodium starch glycolate and crospovidone. Montelukast sodium is a leukotriene receptor antagonist, used in the treatment of asthma and Desloratadine is a drug used to treat allergies the combination formulation is used for the treatment of allergic rhinitis. The Preparation contains 11 formulations by using direct compression method. The prepared batches of oral disintegrating tablets of Montelukast sodium and Desloratadine can be evaluated fort the pre compression parameters like angle of repose, Cars index, Hausner’s ratio, tapped and bulk density. The post compression parameters were also studied including the Weight variation, Hardness, friability, Thickness, wetting time, In vitro disintegration and the water absorption ratio and In-vitro dissolution studies. In-vitro dissolution studies showed that formulations F4, F10, F11 showed better dissolution of Desloratidine and Montelukast when compared with marketed formulation and among them F11 was found to be better formulation when compared to others. Based on the formulation development and results, F11 formulation was considered as the desired formulation which contains crospovidone 4 % as a super disintegrant.


Cite this article:
Ramu Samineni, Sumalatha. K, Dharani G, Rachana J, Anitha P, Manasa K. Formulation and Evaluation of Oral Disintegrating Tablets of Montelukast Sodium and Desloratidine. Res. J. Pharma. Dosage Forms and Tech.2019; 11(3):152-158. doi: 10.5958/0975-4377.2019.00026.0


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