Author(s): Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain

Email(s): parasvirani@gmail.com

DOI: 10.5958/0975-4377.2015.00014.2   

Address: Paras Virani1,2*, Rajanit Sojitra1, Hasumati Raj2, Vineet Jain2
1Research Scholar 2014, Gujarat Technological University, Gujarat
2Quality Assurance Department, Shree Dhanvantary Pharmacy College, Kim, Surat
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2015


ABSTRACT:
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Irbesartan and atorvastatin in synthetic mixture using simultaneous equation Method. In this spectroscopic method, 226.00 nm and 246.00 nm wavelengths were selected for measurement of absorptivity. Both the drugs show linearity in a concentration range of 05-30 µg/ml at their respective ?max. Accuracy, precision and recovery studies were done by QC samples covering lower, medium and high concentrations of the linearity range. The relative standard deviation for accuracy, precision studies were found to be within the acceptance range (<2%). The limit of determination was 0.033µg/ml and 0.125 µg/ml for Irbesartan and atorvastatin, respectively. The limit of quantification was 0.1008 µg/ml and 0.3792 µg/ml for Irbesartan and atorvastatin, respectively. Recovery of Irbesartan and atorvastatin were found to be 99.75 % and 99.52% respectively confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis since they are rapid, simple, accurate and also sensitive and specific by no heating and no organic solvent extraction.


Cite this article:
Paras Virani, Rajanit Sojitra, Hasumati Raj, Vineet Jain. Development and Validation of Analytical Method for Irbesartan and Atorvastatin by Simultaneous Equation Spectroscopic Method. Res. J. Pharm. Dosage Form. & Tech. 7(2): April-June, 2015; Page 98-102. doi: 10.5958/0975-4377.2015.00014.2


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DOI: 10.5958/0975-4377 


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