Author(s): Abd El-Aziz B. Abd El-Aleem, Shaban M. Khalile, Omneya K. El-Naggar

Email(s): Email ID Not Available

DOI: Not Available

Address: Abd El-Aziz B. Abd El-Aleem1, Shaban M. Khalile2 and Omneya K. El-Naggar2*
1Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt.
2National Organization for Drug Control and Research (NODCAR), Giza, Egypt.

Published In:   Volume - 5,      Issue - 3,     Year - 2013


ABSTRACT:
Simple and sensitive spectophotometric method for determination of sumatriptan (Sum.) and zolmitriptan (Zol.) in pure form and in dosage form has been developed. The charge transfer (CT) reactions between sumatriptan and zolmitriptan as n-electron donor and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 7,7,8,8-tetracyanoquinodimethane (TCNQ) and tetracyanoethylene (TCNE) as p-acceptors have been spectrophotometrically studied. The absorbance is measured at ?max= 459, 843 and 415 for DDQ, TCNQ and TCNE, respectively. The optimum experimental conditions for these CT reactions have been studied carefully. Beer?s law is obeyed in the range of 10-80 µg/ml, 10-50 µg/ml and 10-40 µg/ml for DDQ, TCNQ and TCNE respectively with zolmitriptan drug and in range of 10-100 µg/ml,10-100 µg/ml and 10-70 µg/ml for DDQ, TCNQ and TCNE respectively with sumatriptan drug. Sandell?s sensitivity is calculated. Relative standard deviations were obtained for five replicates of the cited drugs with the mentioned reagents. The results obtained by the three reagents with the two drugs are comparable with those obtained by reported methods in raw materials and in dosage forms. The proposed methods are applied successfully for the determination of the drugs in pure form and in commercial dosage forms.


Cite this article:
Abd El-Aziz B. Abd El-Aleem, Shaban M. Khalile, Omneya K. El-Naggar. 7, 7, 8, 8-Tetracyanoquinodimethane (TCNQ), 2,3-Dichloro-5,6-Dicyano-1,4-Benzoquinone (DDQ) and Tetracyanoethylene (TCNE) Reagents for the Photometric Determination of Sumatriptan and Zolmitriptan in Pure and Dosage Forms.Research J. Pharma. Dosage Forms and Tech. 2013; 5(3): 145-150


Recomonded Articles:

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI:         Access: Open Access Read More

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): A Maru, U Pattamatta , VB Patravale

DOI:         Access: Open Access Read More

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6         Access: Open Access Read More

Author(s): Dharmendra Kumar Kushwah, Prakash Yashwant Kohle, Bimal Kumar Srivastava, Manoj Parmar ,Dhaval Mehta

DOI:         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): R. K.V. Naga Sudha, V. Sai Kishore, CH. Venu Babu, E. Jitendranath

DOI: 10.5958/0975-4377.2015.00016.6         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2017.00022.2         Access: Open Access Read More

Author(s): Debjit Bhowmik, Amrendra Singh , Praveen Khirwadkar, Nishi Shukla, Vikas Kumar Chaudhari

DOI: 10.5958/0975-4377.2016.00027.6         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags