Author(s): Mayank Shah, Kamla Pathak

Email(s): mayankshah139@gmail.com

DOI: Not Available

Address: Mayank Shah* and Kamla Pathak
Department of Pharmaceutics, Rajiv Academy for Pharmacy, National Highway #2, P.O. Chhattikara, Mathura, 281001, Uttar Pradesh, India
*Corresponding Author

Published In:   Volume - 4,      Issue - 6,     Year - 2012


ABSTRACT:
The Purpose of this study was to investigate role of solid lipid nanoparticles (SLNs) on oral bioavailability of simvastatin, and to study the distribution of drug in heart, lungs, liver, spleen, kidney, stomach and intestine. To achieve goal, the SLNs of simvastatin were developed and optimized using 23 factorial designs. Optimized formulation was radiolabelled with technetium-99m and evaluated for pharmacokinetics and biodistribution parameters in Swiss albino mice. At various time points mice were sacrificed humanly and blood/organs were isolated. Percent activity/gram (% A/G) for blood and each organ was determined by gamma ray counter. The optimized formulation of SLN of simvastatin demonstrated a relative bioavailability of 186% in comparison to simvastatin suspension. It is suggested that the transport of SLNs through the intestinal lymphatics avoids presystemic hepatic metabolism and therefore enhances bioavailability. Biodistribution study revealed higher % A/G of Tc 99m in liver for simvastatin suspension when compared to SLNs after 4 hours of administration indicating the ability of SLNs to bypass liver and thus, minimizing the presystemic metabolism.


Cite this article:
Mayank Shah, Kamla Pathak. Solid Lipid Nanoparticles of Simvastatin: Pharmacokinetic and Biodistribution Studies on Swiss albino mice. Research J. Pharma. Dosage Forms and Tech. 2012; 4(6): 336-342.


Recomonded Articles:

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Masheer Ahmed Khan

DOI:         Access: Open Access Read More

Author(s): Nakkala Balaji , V. Sai Kishore , Kasani Hari Krishna Gouda

DOI:         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Shoaib Ahmad

DOI: 10.5958/0975-4377.2016.00041.0         Access: Open Access Read More

Author(s): P. Lekshmi, K. Pramod, K.C. Ajithkumar

DOI: 10.5958/0975-4377.2016.00007.0         Access: Open Access Read More

Author(s): V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren

DOI:         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2018.00036.8         Access: Closed Access Read More

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0         Access: Open Access Read More

Author(s): Deepak Khobragade, Sunil Kumar, Arun Kotha, Richa Gupta, K. Ravalika

DOI: 10.5958/0975-4377.2016.00024.0         Access: Open Access Read More

Author(s): Patil Amol M, Todkar Rohit R, Gumte Dipak S, S.K. Mohite, C.S. Magdum

DOI: 10.5958/0975-4377.2016.00030.6         Access: Open Access Read More

Author(s): Patil GB, Deshmukh PK, Belgamwar VS

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags