Author(s): Basini Nikunja Pati, Patel Jitendra, Qureshi Md Shamim, Kumar G.S

Email(s): jittu_pharmacy@rediffmail.com

DOI: Not Available

Address: Basini Nikunja Pati1*, Patel Jitendra1, Qureshi Md Shamim2 and Kumar G.S3.
1Department of Pharmaceutics, Bharat Institute of Technology-School of Pharmacy, Mangalpally, Imbrahmpatnam, RR Dist- 501510, AP, India.
2Anwarul Uloom College of Pharmacy, New Mallepally, Hyderabad -500001.
3Department of Pharmacognosy, Gitam Institute of Pharmacy, Gitam University Gandhinagar Campus, rushikonda Visakhapatnam-530045.
*Corresponding Author:

Published In:   Volume - 2,      Issue - 5,     Year - 2010


ABSTRACT:
In the long-term management of patients suffering from peptic ulcer and Zollinger Ellison Syndrome, hig and repeat dosing may be required. Here an antiulcerative drug, Rabeprazole sodium was selected for research work. Since it is largely absorbed from the upper intestine, selective delivery of drugs into the colon may be regarded as a better method of drug deliver with fewer side effects and a higher efficacy. The aim of this study was to prepare and evaluate a double coated multiparticulate system for Rabeprazole delivery using ethyl cellulose and mucoadhesive polymers as the primary and secondary polymer respectively and studied. Ethyl cellulose microparticles containing Rabeprazole was produced using the solvent evaporation method. Prepared ethyl cellulose microparticle were spherical, free flowing, non-aggregated and showed no degradation in the acidic medium. Entrapment efficacy of microparticles was about 68.5%. Results showed that drug release was fast and complete and is affected by the amount of core material entrapped. Ethylcellulose microparticles were then coated by various mucoadhesive polymers using emulsion solvent evaporation (ESE) technique. Here, two mucoadhesive polymers (HPMC and PVP) have been selected for the study. The idea for this approach was to prepare a mucoadhesive controlled drug delivery system, in which, ethyl cellulose gives a controlled release of the drug and the mucoadhesive property of the coating polymer helps in complete drug release by its localization (ulcer sites) as well as systemic action (in colon) resulting in more bioavailability, less degradation of drug and relief from the adverse effects of the drug. It was shown that this system could provide a suitable drug release pattern for delivery of active agents.


Cite this article:
Basini Nikunja Pati, Patel Jitendra, Qureshi Md Shamim, Kumar G.S. Preparation of Double Coated Multiparticulate Delivery System for an Anti-ulcerative Drug. Research J. Pharma. Dosage Forms and Tech. 2010; 2(5): 335-339


Recomonded Articles:

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Masheer Ahmed Khan

DOI:         Access: Open Access Read More

Author(s): Nakkala Balaji , V. Sai Kishore , Kasani Hari Krishna Gouda

DOI:         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Shoaib Ahmad

DOI: 10.5958/0975-4377.2016.00041.0         Access: Open Access Read More

Author(s): V Ganesan, Nilesh P Tekade, Nitin S Bhajipale, Durgesh R Dewade, Raju R Thenge

DOI:         Access: Open Access Read More

Author(s): V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren

DOI:         Access: Open Access Read More

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0         Access: Open Access Read More

Author(s): Patil GB, Deshmukh PK, Belgamwar VS

DOI:         Access: Open Access Read More

Author(s): Amrita Thakur, Nisha Nair, Mukta Agrawal, Yashi Thakur, Juhi Thakur,TemanNirmalkar,VedPrakashVerma,Vibhash Gupta,Vivek Singh Yadav,KalpanaMahilange, PoojaMahant, PritamYadav, Deepak Patel, Dinesh Khamari, JyotsanaMeshram, RakeshSahu, TarunGhatode, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0975-4377.2018.00018.6         Access: Open Access Read More

Author(s): Viswanadham Manasa, K.Vanitha, M. Venkataswamy, P. Prabhakar, Alluri Ramesh

DOI: 10.5958/0975-4377.2016.00002.1         Access: Open Access Read More

Author(s): Selvaraju K., Vengadesh Prabhu K., Karthick K., Padma Preetha J., Arul Kumaran K.S.G.

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags