Author(s): Jaydeep S Chauhan, Jigar Vyas, U.M. Upadhyay

Email(s): drjigarvyas@gmail.com , jaydeepchauhanc275@gmail.com

DOI: 10.52711/0975-4377.2023.00038   

Address: Jaydeep S Chauhan1, Jigar Vyas2, U.M. Upadhyay3
1Sigma Institute of Pharmacy, Bakrol Vadodara, Gujarat, India.
2Sigma Institute of Pharmacy, Bakrol Vadodara, Gujarat, India.
3Sigma Institute of Pharmacy, Bakrol Vadodara, Gujarat, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 4,     Year - 2023


ABSTRACT:
Introduction: The two key challenges for formulation scientists in developing therapeutic delivery are the dissolution and solubility of a low aqueous-soluble drug. Many powerful drug molecules do not have therapeutic effects owing to solubility concerns, yet they can be dangerous when administered in large dosages. Solid dispersion technology is a good method for increasing solubility and dissolution, along with bioavailability. Material and Methods: solid dispersion of rosuvastatin was developed using casein, infant formula, and poly-ethylene glycol 6000 by conventional fusion method and characterized for several characterization parameters. Conclusion: Solid dispersion of rosuvastatin was efficiently developed. The dissolution of rosuvastatin solid dispersion was discovered to be noticeably increased as compared to rosuvastatin API, according to the current investigation, SD of rosuvastatin was a superior alternative for increasing the dissolution of weakly soluble therapeutic agent.


Cite this article:
Jaydeep S Chauhan, Jigar Vyas, U.M. Upadhyay. Enhancement of water solubility of Poorly Water-soluble drug using milk protein as carrier. Research Journal of Pharmaceutical Dosage Forms and Technology2023; 15(4):236-0. doi: 10.52711/0975-4377.2023.00038

Cite(Electronic):
Jaydeep S Chauhan, Jigar Vyas, U.M. Upadhyay. Enhancement of water solubility of Poorly Water-soluble drug using milk protein as carrier. Research Journal of Pharmaceutical Dosage Forms and Technology2023; 15(4):236-0. doi: 10.52711/0975-4377.2023.00038   Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-4-3


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