Author(s): Vaseeha Banu T.S, Jaiswal Vikas Awdesh, Mohammad Sameer Ansari

Email(s): mail2vaseeha@gmail.com

DOI: 10.52711/0975-4377.2022.00031   

Address: Vaseeha Banu T.S1, Jaiswal Vikas Awdesh2, Mohammad Sameer Ansari1
1M.M.U. College of Pharmacy, K.K. Doddi, Ramanagara - 562159, Karnataka state.
2Vivekananda College of Pharmacy, Dr. Rajkumar Road, Rajajinagar, Bangalore-55.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2022


ABSTRACT:
Pseudoephedrine HCl (PEH) is a sympathomimetic drug used as a nasal decongestant. In this study an attempt has been made to formulate transdermal films of PEH using HPMC and PVP as polymers, DMSO as plasticizer and DBP as permeation enhancer by solvent casting technique. The prepared films were evaluated for various physicochemical parameters viz., weight variation, drug content, surface pH, folding endurance, tensile strength WVTR and stability studies of optimized formulation. The in vitro drug release was determined by using modified Franz diffusion cell by using phosphate buffer (pH 7.4) as diffusion medium. Among the two polymers used the HPMC has given the good results with formulation F6 emerged out as a best formulation among all six prepared by using with flux of 28.23 ±1.202 mentioned polymer alone and in combination. The obtained results concluded that the PEH transdermal films are promising delivery system in the treatment of nasal congestant.


Cite this article:
Vaseeha Banu T.S, Jaiswal Vikas Awdesh, Mohammad Sameer Ansari. Formulation and Evaluation of Transdermal Patches of Decongestant Drug. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(3):195-8. doi: 10.52711/0975-4377.2022.00031

Cite(Electronic):
Vaseeha Banu T.S, Jaiswal Vikas Awdesh, Mohammad Sameer Ansari. Formulation and Evaluation of Transdermal Patches of Decongestant Drug. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(3):195-8. doi: 10.52711/0975-4377.2022.00031   Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-3-1


REFERENCES:
1.    Remington, “The Science and Practice of Pharmacy”, 21st edition, Volume 1, published by B.I. Publications, 2006: 871-876.
2.    Chien Y.W, “Novel drug delivery system”, 2nd edition, vol-50, Marcel dekker, Inc, New York: 139-143.
3.    Banu TS Vaseeha, Sukhen Som, Development and Evaluation of Transdermal Films of Oxybutynin, Research Journal of Pharmaceutical Dosage Forms and Technology. 2010; 2(2): 178-183.
4.    Rahman G, Syed UJ, Syed F, Samiullah S. Preliminary phytochemical screening, quantitative analysis of alkaloids, and antioxidant activity of crude plant extracts from ephedra intermedia indigenous to balochistan. Hindawi 2017; 1:1-7.
5.    Gul R, Jan US, Ahmad M, Akhtar M, Faridullah S. Formulation, characterization, in vitro and ex vivo release of Ephedra extract from topical preparations using dialysis membrane and rabbit skin. Dissolution Technol 2017; 24: 24–30.
6.    Manjusha, Ganju K, Pathak AK. Formulation and evaluation of transdermal patch of pyrochlore perazine maleate for the hyperemesis gravidarum. International Journal of Research in Pharmacy and chemistry, 2011;1(4):1115-1125.
7.    Vaseeha Banu TS, Sukhen Som, Development and evaluation of transdermal films of oxybutynin. RJPDFT. 2010; 2(2): 178-183.
8.    Bagyalakshmi J, Vmshikrishna RP. Preparation, optimization and in vitro and vivo evaluation of membrane-moderated transdermal delivery of ampicillin sodium. AAPS Pharm. Sci. Tech, 2008; 8(1):50-55.
9.    Das MK, Bhattacharya A, Ghoshal SK. Transdermal Delivery of Trazodone Hydrochloride from Acrylic Films Prepared from Aqueous Latex. Indian Journal of Pharmaceutical Sciences, 2006; 68(1):41-46.
10.    Jamaandi VG, Mulla JS, Vinay BL. Formulation and evaluation of matrix- type transdermal patches of a model antihypertensive drug. Asian Journal of Pharmaceutics, 2009; 8(1):59-65.
11.    Aurora P, Mukherjee B. Design, development, physicochemical, and in-vitro and in-vivo evaluation of transdermal patches containing diclofenac diethyl ammonium salt. International Journal of Pharm. Tech Research, 2009; 25(1):12-21
12.    Murthy GK, Ramana RV, Kishore BM. 2008. Influence of polymers on the release of Carvedilol from transdermal films. Indian Drugs, 45(12):970- 974.
13.    Gupta R, Mukherjee B. Development and in vitro evaluation of diltiazem hydrochloride transdermal patches based on povidone–ethylcellulose matrices. Drug Dev Ind Pharm 2003; 29:1-7.
14.    Vaseeha Banu TS, Sukhen Som, Mohamed Khaleel and Nirmal TH, Transdermal drug delivery system of Salbutamol sulphate: formulation and evaluation. RJPDFT, 2010; 2(1): 56-61.
15.    Vaseeha Banu TS, Sukhen Som, Preparation and evaluation of transdermal films of oxybutynin, RJPDFT. 2009; 1(2): 130-134.
16.    Biswajit M, Sushmita M, Ritu G, Balaram P. A comparison between povidoning-ethylcellulose and povidone-eudragit transdermal dexamethasone matrix patches based on in vitro skin permeation. Eur J Pharm Biopharm 2005; 59:475–8.

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