In the last decades, the number of patients receiving chemotherapy has considerably increased. Given the toxicity of cytotoxic agents to humans, the development of reliable analytical methods to analyze these compounds became necessary. The arrival of a great number of new antineoplastic agents has made it necessary to reclassify all of them. Anticancer drugs may act at different levels: cancer cells, endothelium, extracellular matrix, and the immune system or host cells. The tumour cell can be targeted at the DNA, RNA or protein level. Most classical chemotherapeutic agents interact with tumour DNA, whereas monoclonal antibodies and small molecules are directed against proteins. The endothelium and extracellular matrix may be affected also by specific antibodies and small molecules.
Cite this article:
Kundan J. Tiwari, Komal Jadhav. Cancer is a Life-Threatening Disease: A Review. Res. J. Pharma. Dosage Forms and Tech.2020; 12(2): 111-114. doi: 10.5958/0975-4377.2020.00020.8