Author(s): Chinmaya Keshari Sahoo, Surepalli Ram Mohan Rao, Muvvala Sudhakar, D. Venkata Ramana, Kanhu Charan Panda

Email(s): sahoo.chinmaya83@gmail.com

DOI: 10.5958/0975-4377.2018.00028.9   

Address: Chinmaya Keshari Sahoo1, Surepalli Ram Mohan Rao2, Muvvala Sudhakar3, D. Venkata Ramana4, Kanhu Charan Panda5
1Ph.D Scholar, Department of Pharmaceutics, Faculty of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana-500007.
2Professor, Mekelle Institute of Technology, Mekelle University, Mekelle, Ethiopia.
3Professor and Principal, Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana-500014.
4Professor and Principal, Department of Pharmaceutical Technology, Netaji Institute of Pharmaceutical Sciences, Toopranpet, Yadadri Bhongir, Telangana–508252
5Associate Professor, Department of Pharmaceutics, Anwarul Uloom College of Pharmacy, Newmallepally,
Hyderabad, Telangana
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2018


ABSTRACT:
The current research was designed to develop controlled porosity osmotic pump (CPOP) tablets of stavudine a nucleoside reverse transcriptase inhibitor for the treatment of acquired immune deficiency syndrome (AIDS) Wet granulation method was adopted for the development of tablet of 80 mg dose of stavudine for once daily. The formulated tablets were evaluated for pre compression parameters, post compression parameters, in vitro dissolution study and scanning electron microscopy study. The in vitro release kinetics were analyzed for different batches by different pharmacokinetic models such as zero order, first order, Higuchi, Korsmeyer Peppas and Hixon Crowell model. The results of optimized formulation releases drug up to 18 h in a controlled manner and follow Higuchi kinetics and which is independent of the pH and agitation intensity. Short term stability study at 40±2ºC/75±5% RH for three months was carried out and observed that the optimized formulation did not show any significant changes in hardness, friability, weight variation, drug content, in vitro dissolution study etc.


Cite this article:
Chinmaya Keshari Sahoo, Surepalli Ram Mohan Rao, Muvvala Sudhakar, D. Venkata Ramana, Kanhu Charan Panda. Formulation and Evaluation of Controlled Porosity Osmotic Pump Tablets for Oral Delivery of Stavudine. Res. J. Pharma. Dosage Forms and Tech.2018; 10(3):179-187. doi: 10.5958/0975-4377.2018.00028.9


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DOI: 10.5958/0975-4377 


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