The aim of present study was to increase the solubility of glibenclamide in water by hydrotropic solubilization. Sodium acetate, sodium citrate, sodium salicylate and sodium benzoate were used as the hydrotropic agents. In order to elucidate the probable mechanism of solubilization, the solution properties such as surface tension, viscosity, specific gravity were studied. Sodium salicylate was found to be the most suitable hydrotropic agent to increase the solubility of glibenclamide. The solubility of Glibenclamide by various hydrotropes was in decreasing order of Sodium acetate>sodium salicylate>sodium citrate>sodium benzoate. Initial increase in solubility of Glibenclamide was due to the weak ionic interactions between the hydrotropes and glibenclamide molecules, multifold increase in solubility at higher concentration of hydrotrope was due to molecular aggregation.
Cite this article:
P. Sabitha Reddy, C. Swetha , K. Ravindra Reddy. Effect of Hydrotropes and Physical Properties on Solubility of Glibenclamide. Research J. Pharma. Dosage Forms and Tech. 2011; 3(6): 294-297.