Author(s): Muskan Rathor, Anshika Garg

Email(s): anshikacreations03@gmail.com

DOI: 10.52711/0975-4377.2024.00015   

Address: Muskan Rathor, Anshika Garg
Sanskar College of Pharmacy and Research, 201302, Ghaziabad, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2024


ABSTRACT:
Gastric emptying is a complex and incredibly factor process. This causes the unusualness of the bioavailability of medication delivery system. GRDDSs can improve the controlled delivery of medications that have an ingestion window by continuously delivering the medication for a delayed time before it arrives at its assimilation site. Gastro retentive drug delivery system (GRDDS)s have gotten huge consideration in the previous many years, because of the way that they can overcome the limitations of regular oral controlled released drug delivery system identified with quick gastric emptying time. An ideal GRDDS can be characterized as a system which stays in the stomach for an adequate time and deliver the active ingredients in a controlled way so that sustained action can be created. This, altogether broadens the duration of medication release, prolongs dosing interval and expands bioavailability of medications and consequently improves compliance of the patients and viability of pharmacotherapy. This article gives an outline of the fundamental ideas used to design drug dosage form with delayed gastric residence time as well as the factors influencing gastric emptying, favourable circumstances, deficiencies, formulation consideration and, elements that influence gastro retentive system. The principal emphasis is on the whole grouping and various types of GRDDSs.


Cite this article:
Muskan Rathor, Anshika Garg. Gastroretentive drug delivery system: An Overview. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(1):91-7. doi: 10.52711/0975-4377.2024.00015

Cite(Electronic):
Muskan Rathor, Anshika Garg. Gastroretentive drug delivery system: An Overview. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(1):91-7. doi: 10.52711/0975-4377.2024.00015   Available on: https://rjpdft.com/AbstractView.aspx?PID=2024-16-1-15


REFERENCES:
1.    Sakr FM. A programmable drug delivery system for oral administration. International Journal of Pharmaceutics. 1999; 184: 131–139.
2.    Pradip Landge, Jiwan Lavande, Avinash Swami, Vishweshwar Dharashive. A Review on Gastroretentive Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology. 2023; 15(1): 62-8. doi: 10.52711/0975-4377.2023.00011
3.    Wilding IR, Coupe AJ, Davis SS. The role of γscintigraphy in oral drug delivery. Advanced Drug Delivery Reviews. 1991;7:87–117
4.    Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. Journal of Controlled Release. 2000; 63: 235–259.
5.    Ghanbarzadeh S, Valizadeh H, Zakeri-Milani P. Application of Factorial Designs and Response Surface Methodology in Formulation Development of Sirolimus Liposome Prepared by Thin Film Hydration Technique. BioImpacts. 2013; 3:In Press
6.    Efentakis M, Politis S. Comparative evaluation of various structures in polymer controlled drug delivery systems and the effect of their morphology and characteristics on drug release. European Polymer Journal. 2006; 42: 1183–1195.
7.    Sun Y, Peng Y, Chen Y, Shukla AJ. Application of artificial neural networks in the design of controlled release drug delivery systems. Advanced Drug Delivery Reviews. 2003; 55: 1201–1215.
8.    Chen R-N, Ho H-O, Yu C-Y, Sheu M-T. Development of swelling/floating gastroretentive drug delivery system based on a combination of hydroxyethyl cellulose and sodium carboxymethyl cellulose for Losartan and its clinical relevance in healthy volunteers with CYP2C9 polymorphism. European Journal of Pharmaceutical Sciences. 2010; 39: 82–89.
9.    Chen Y-C, Ho H-O, Lee T-Y, Sheu M-T. Physical characterizations and sustained release profiling of gastroretentive drug delivery systems with improved floating and swelling capabilities. International Journal of Pharmaceutics. 2013; 441: 162–169.
10.    Rao GK, Mandapalli PK, Manthri R, Reddy VP. Development and in vivo evaluation of gastroretentive delivery systems for cefuroxime axetil. Saudi Pharmaceutical Journal. 2013; 21: 53–59.
11.    Qin C., Wu M., Xu S., Wang X., Shi W., Dong Y., Yang L., He W., Han X., Yin L. Design and optimization of gastro-floating sustained-release tablet of pregabalin: In vitro and in vivo evaluation. Int. J. 20 Pharm. 2018; 545: 37–44. doi: 10.1016/j.ijpharm.2018.04.011.
12.    Timmermans J., Moes A.J. How well do floating dosage forms float? Int. J. Pharm. 1990;62:207–216. doi: 10.1016/0378-5173(90)90234- U.
13.    Vijay Chudiwal, Sadhana Shahi. Patent Perspective of Advanced Gastroretentive Drug Delivery Systems. Res. J. Pharm. Dosage Form. & Tech. 2016; 8(1): 15-23. doi: 10.5958/0975-4377.2016.00003.3
14.    Priya Patel, Rohini Sahu, Renjil Joshi, Surabhi Armarkar, Tarannum Parveen, Narendra Pratap, Renuka Sahu, Pushpanjali Sahu, Dujram Sahu, Rupali Manikpuri, Madhav Patel, Tikeshwar Sahu, Bhupendra Rajak, Parmanand Sahu, Pooja Yadav, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander. A Comprehensive Note on Gastro-Retentive Dosage Forms. Res. J. Pharma. Dosage Forms and Tech. 2018; 10(2): 85-89. doi: 10.5958/0975-4377.2018.00013.7
15.    Nirav Patel, Nagesh C., Chandrashekhar S., Patel Jinal, Jani Devdatt. Floating drug delivery system: An innovative acceptable approach in gastroretentive drug delivery. Research J. Pharma. Dosage Forms and Tech. 2012; 4(2): 93-103.
16.    Gadge G. Gunjan. Gastro Retentive Floating Drug Delivery System: An Overveiw. Res. J. Pharma. Dosage Forms and Tech. 2020; 12(3): 213-226. doi: 10.5958/0975-4377.2020.00036.1
17.    Wang Y.T., Mohammed S.D., Farmer A.D., Wang D., Zarate N., Hobson A.R., Hellström P.M., Semler J.R., Kuo B., Rao S.S. Regional gastrointestinal transit and pH studied in 215 healthy volunteers using the wireless motility capsule: Influence of age, gender, study country and testing protocol. Aliment. Pharmacol. Ther. 2015; 42: 761–772. doi: 10.1111/apt.13329.
18.    Arora, S; Ali, J; Ahuja, A; Khar, RK and Baboota, S.Floating Drug Delivery Systems: A Review; AAPS Pharm Sci. Tech, 2005; 47: 372- 390.
19.    Mayavanshi AV and Gajjar SS; Floating Drug Delivery System to Increase Gastric Retention of Drugs; Res. J. Pharma. Dosage Forms and Tech. 2008; 1(4): 345-348.
20.    Rossi A., Conti C., Colombo G., Castrati L., Scarpignato C., Barata P., Sandri G., Caramella C., Bettini R., Buttini F. Floating modular drug delivery systems with buoyancy independent of release mechanisms to sustain amoxicillin and clarithromycin intra-gastric concentrations. Drug Dev. Ind. Pharm. 2016; 42: 332–339. doi: 10.3109/03639045.2015.1054397.
21.    Michaels A. Drug Delivery Device with Self Actuated Mechanism for Retaining Device in Selected Area. 3,786,813. U.S. Patent. 1974 Jan 22;
22.    Sato Y, Kawashima Y, Takeuchi H, Yamamoto H. In vitro evaluation of floating and drug releasing behaviors of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method. European Journal of Pharmaceutics and Biopharmaceutics. 2004; 57: 235– 243
23.    Vasir JK, Tambwekar K, Garg S. Bioadhesive microspheres as a controlled drug delivery system. International Journal of Pharmaceutics. 2003; 255: 13– 32.
24.    Nayak AK, Das B, Maji R. Gastroretentive hydrodynamically balanced systems of ofloxacin: In vitro evaluation. Saudi Pharmaceutical Journal. 2013; 21: 113–117.
25.    Tina Raju, Tanushree Sarkar, Bhagyashree S. Patil, Amol A. Raskar. Microballoons- Novel Carriers in Gastro Retentive Drug Delivery. Res. J. Pharm. Dosage Form. and Tech. 2015; 7(4): 266-273. doi: 10.5958/0975-4377.2015.00038.5
26.    Rajesh Mujoriya , Ramesh Babu Bodla. A Overview on Study of Floating Drug Delivery Systems. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1): 01-13.
27.    Kasani Harikrishna Gouda, V. Sai Kishore, N. Balaji, V. Vijaya Kumar, N. Raghuram. An Overview on Various Approaches for Gastroretentive Drug Delivery systems. Research J. Pharma. Dosage Forms and Tech. 2011; 3(4): 159-168.
28.    Yashpal Singh Chauhan, Udichi Kataria, Ashok Dashora. Importance of Floating Drug Delivery System. Res. J. Pharm. Dosage Form. & Tech. 2018; 10(4): 220-232. doi: 10.5958/0975-4377.2018.00034.4
29.    Pravin N. Ghule, Amol S. Deshmukh, Vijay R. Mahajan. Floating Drug Delivery System (FDDS): An Overview. Res. J. Pharm. Dosage Form. and Tech. 2014; 6(3): 174-182.
30.    Carcaboso ÁM, Chiappetta DA, Höcht C, et al. In vitro/in vivo characterization of melt-molded gabapentin-loaded poly (epsiloncaprolactone) implants for sustained release in animal studies. European Journal of Pharmaceutics and Biopharmaceutics. 2008; 70: 666–673.
31.    Murphy CS, Pillay V, Choonara YE, Du Toit LC. Gastroretentive drug delivery systems: Current developments in novel system design and evaluation. Current Drug Delivery. 2009; 6: 451–460.
32.    Manmohan M, Shukla TP, Mathur A, Upadhyay N, Sharma S. A review on gastroretentive drug delivery system: An emerging approach to improve the gastric residence time of solid dosage forms. International Journal of Pharmaceutical Sciences Review and Research. 2011; 8: 176–182.
33.    Dadage Ketan K, Sakhare Ram S, Halle Pradeep D, Nabde Mahesh K, Raut Deepika B. An updated overview: Floating (gastroretensive) drug delivery system. Research Journal of Pharmacy and Technology. 2012; 5: 1467–147.
34.    Jiménez-Castellanos MR, Zia H, Rhodes CT. Design and testing in vitro of a bioadhesive and floating drug delivery system for oral application. International Journal of Pharmaceutics. 1994; 105: 65– 70.
35.    Javadzadeh Y, Hamedeyazdan S, Adibkia K, Kiafar F, Zarrintan MH, Barzegar-Jalali M. Evaluation of drug release kinetics and physicochemical characteristics of metronidazole floating beads based on calcium silicate and gas-forming agents. Pharmaceutical Development and Technology. 2010; 15: 329–338.
36.    Dey S.K., De P.K., De A., Ojha S., De R., Mukhopadhyay A.K., Samanta A. Floating mucoadhesive alginate beads of amoxicillin trihydrate: A facile approach for H. pylori eradication. Int. J. Biol. Macromol. 2016; 89: 622–631. doi: 10.1016/j.ijbiomac.2016.05.027.
37.    Darandale S.S., Vavia P.R. Design of a gastroretentive mucoadhesive dosage form of furosemide for controlled release. Acta Pharm. Sin. B. 2012; 2: 509–517. doi: 10.1016/j.apsb.2012.05.004.
38.    Saranya R., Elango K., Devi Damayanthi N., Balaguru A. Formulation and Evaluation of Hydrogel for Stomach Specific Drug Delivery of Lamivudine. Research J. Pharm. and Tech. 2013; 6(7): 740-745.
39.    Sanjesh G Rathi, Poonam S Yadav, Sohan S Vaghela, Shrenik S Shah. Formulation and Evaluation of Stomach Specific Floating Tablets of Eluxadoline. Research Journal of Pharmacy and Technology. 2022; 15(3):1267-2.
40.    Ashwini A Zanke, Hemant H Gangurde, Ananta B Ghonge, Praful S. Chavan. Recent Advance in Gastroretantive Drug Delivery System (GRDDS). Asian Journal of Pharmaceutical Research. 2022; 12(2):143-9.
41.    Waghmare Sneha S., Kadam Trupti V., Darekar A. B., Saudagar R. B.. A Review: Floatable Gastroretentive Drug Delivery System. Asian J. Pharm. Res. 2015; 5(1): 51-60.
42.    Archana Rajmane, Rahul Trivedi, TanajiNandgude. A Novel approach to Enhance Gastric Retention for better Therapeutic Activity: Gastro Retentive Drug Delivery System. Research Journal of Pharmacy and Technology. 2022; 15(7):3324-0.
43.    Bina Gidwani, Amber Vyas, KhemkaranAhirwar, S. S. Shukla, Ravindra Pandey, Chanchal Deep Kaur. Factorial Design and a Practical Approach for Gastro-Retentive Drug Delivery System. Research J. Pharm. and Tech. 2016; 9(6):641-649.

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