Author(s):
Pratibha. B. Wakchaure, Maya. Y. Gaikwad
Email(s):
gaikwadmau012@gmail.com
DOI:
10.52711/0975-4377.2022.00038 
Address:
Pratibha. B. Wakchaure1, Maya. Y. Gaikwad2*
1Student, SMBT Institute of D. Pharmacy, Dhamangaon, Nashik.
2Lecturer, SMBT Institute of D. Pharmacy, Dhamangaon, Nashik.
*Corresponding Author
Published In:
Volume - 14,
Issue - 3,
Year - 2022
ABSTRACT:
The motivation of writing this review on micro balloons is a Gastro retentive drug delivery system are micro balloons (hollow microsphere) are a drug delivery system that promises to be a potential approach for gastric retention. Microballoons drug delivery system is novel drug delivery on the foundation of non- effervescent system that containing empty particles of spherical shape without core ideally having a size less than 200 micrometers which is designed to be retained in the stomach for a prolonged period of time and release their active ingredients and thereby enable sustained and prolonged input of the drug in the upper part of the gastrointestinal (GI) tract. They are gastro retentive drug-delivery systems, which provide controlled release properties for a drug. Recently gastro retentive drug delivery system (GRDDS) are gaining wide acceptance for drugs with narrow absorption windows, decreased stability at high alkaline pH, and increased solubility at low pH. The design of this article is to compose the various gastro retentive arrive. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling retention i.e. high density, floating, bio-or that adheres to a mucous membrane (adjective), extensile, attractor etc. In addition of central element controlling gastro retention, superiority and finally future potential are discussed.
Cite this article:
Pratibha. B. Wakchaure, Maya. Y. Gaikwad. Microballoons: An Advanced Avenue for Gastro Retentive Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(3):233-7. doi: 10.52711/0975-4377.2022.00038
Cite(Electronic):
Pratibha. B. Wakchaure, Maya. Y. Gaikwad. Microballoons: An Advanced Avenue for Gastro Retentive Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(3):233-7. doi: 10.52711/0975-4377.2022.00038 Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-3-8
REFERENCES:
1. Vyas SP, Khar RK, Targeted and controlled Drug Delivery Novel carrier system, New Delhi: CBS publishers and Distributors; 2002, 417-54.
2. Dhole AR, Gaikwad PD, Banker VH, Pawar SP, A Review on floating multiparticular drug delivery system. A Novel Approach to Gastric retention, IJSRR. 2011; 6(2): 205-211.
3. Kawashima Y, Niwa T, Takenchi H, Hino T, 1to h y. Hollow microspheres for use as a floating controlled drug delivery system in the stomach. J. Pharm.sci. 1992; 81: 135-140.
4. Ichikawa M, Watanable S, Miyake Y. A new multiple unit oral floating dosage system 11: in vivo evaluation of floating and sustained release characteristics with para amino benzoic acid and isosorbidedinitrate as model drugs. J. Pharm. Sci. 1991; 80: 1153-1156.
5. Nilkhumhang N, Basit AW. Flexibility of an emulsion solvent evaporation method to prepare pH- responsive microparticles Int. J. Pharm. 2009; 377: 135-141.
6. Patil k, Tekade BW, Thakare VM, Patil VR. Formulation and evaluation of Atenolol floating microsphere. Pharma Tutor Pharmacy Infopedia.
7. Abhijeet A. Durgavale, Archana R. Dhole, shrinivas k. mohite, chandrakant s. Magdum. Formulation and evaluation of floating microsphere of captopril using different gas forming agents. AM. J. Pharm. Tech. Res. 2012; 2(2): 56-63.
8. Gattani YS, Kawtikwar PS, Sakarkar DM. Formulation and evaluation of gastro retentive multiparticulate drug delivery system of acceclofenac. Int. J. Chem. Tech. Res. 2009; 1: 1-10.
9. Dhulipati R. Formulation and evaluation of floating microspheres of metformin hydrochloride. Pharmatutor -Art-1055.
10. Kumar k, Rai AK-Development and evaluation of floating microspheres of curcumin. Tropical Journal of Pharmaceutical Research. 2012; 6(3): 190-197.
11. Kumar R and Philip A. Gastro retentive dosage forms for prolonging gastric residence time. Int J Pharm Med. 2007; 21(2): 157-171.
12. Mali AD. Bathe RS. An updated review on micro balloons for better approach in gastro retentive. Asian J. Res. Pharm. Sci. 2015; 5(3): 188-192.