Author(s): Hindustan Abdul Ahad, Haranath Chinthaginjala, Abdalrahman Mohammed Salih Karar, Musab Idris Mohammed Ali Saeed, Aladin Khalaf Alla Elhaj Eltahir Alawad

Email(s): abdulhindustan@gmail.com

DOI: 10.52711/0975-4377.2021.00045   

Address: Hindustan Abdul Ahad*, Haranath Chinthaginjala, Abdalrahman Mohammed Salih Karar, Musab Idris Mohammed Ali Saeed, Aladin Khalaf Alla Elhaj Eltahir Alawad
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Ananthapuramu – 515721, AP, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2021


ABSTRACT:
The authors aimed to extend the discharge of Sirolimus from the tablets with a blend of herbal and synthetic polymers. In this study, Sirolimus was taken as a model drug, Hydroxy Propyl Methyl Cellulose as a synthetic polymer and mucilage from Hibiscus rosa sinensis leaves as a natural polymer. Sirolimus is an orphan drug used to treat Lymphangioleiomyomatosis damage and to suppress body refuse towards the transplanted organs. Sirolimus matrix tablets made with the blend of Hibiscus rosa sinensis leaves mucilage and Hydroxy Propyl Methyl Cellulose. The blend was assessed for flow possessions and the designed tablets were categorized for official and non-official tests including Sirolimus discharge. The Sirolimus matrix tablets possess good Sirolimus content with passible pre and post-formulation parameters. The study concludes that there were no chemical interactions between Sirolimus with polymers used. The study also revealed that Hibiscus rosa sinensis leaves mucilage can be a good polymer in grouping with other polymers for prolonged drug discharge.


Cite this article:
Hindustan Abdul Ahad, Haranath Chinthaginjala, Abdalrahman Mohammed Salih Karar, Musab Idris Mohammed Ali Saeed, Aladin Khalaf Alla Elhaj Eltahir Alawad. Effective Management of Rare Lymphangioleiomyomatosis Using Sirolimus: Tablet Matrix with Hibiscus rosa sinensis Leave Mucilage. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(4):276-0. doi: 10.52711/0975-4377.2021.00045

Cite(Electronic):
Hindustan Abdul Ahad, Haranath Chinthaginjala, Abdalrahman Mohammed Salih Karar, Musab Idris Mohammed Ali Saeed, Aladin Khalaf Alla Elhaj Eltahir Alawad. Effective Management of Rare Lymphangioleiomyomatosis Using Sirolimus: Tablet Matrix with Hibiscus rosa sinensis Leave Mucilage. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(4):276-0. doi: 10.52711/0975-4377.2021.00045   Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-4-2


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DOI: 10.5958/0975-4377 


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