Author(s): Sara Sadique, Ramya Sri S.

Email(s): ramyasuralabs2@gmail.com

DOI: 10.5958/0975-4377.2020.00003.8   

Address: Sara Sadique1*, Ramya Sri S.2
1Department of Pharmaceutics, Global College of Pharmacy, Jawaharlal Nehru Technological University, Hyderabad, Telangana, India.
2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, Telangana, India.
*Corresponding Author

Published In:   Volume - 12,      Issue - 1,     Year - 2020


ABSTRACT:
The fast dissolving oral film of losartan potassium were prepared using different polymers like PVP, HPMC and Pectin by solvent casting method. The fast dissolving oral film evaluated for folding endurance, swelling index, surface pH, in vitro disintegration time, drug content, drug polymer compatibility (IR Study), and in vitro drug release. The physical appearance and folding endurance properties were found to be good. The average folding endurance time within the range of 112 to 208. The drug content showed uniform mixing of drug in all prepared fast dissolving films. The in vitro drug release showed 78 to 96 % drug release within 5 minutes. Drug release obeys the first order kinetics. Hence it can be inferred that the fast dissolving oral film of losartan potassium may produce the rapid action thereby improving bioavilability and enhance the absorption by avoiding the first pass effect.


Cite this article:
Sara Sadique, Ramya Sri S. Preparation and Evaluation of Fast Dissolving Oral Film of Losartan Potassium. Res. J. Pharma. Dosage Forms and Tech.2020; 12(1): 13-16. doi: 10.5958/0975-4377.2020.00003.8


Recomonded Articles:

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2017.00022.2         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8         Access: Open Access Read More

Author(s): Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe

DOI:         Access: Open Access Read More

Author(s): V Ganesan, Nilesh P Tekade, Nitin S Bhajipale, Durgesh R Dewade, Raju R Thenge

DOI:         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2018.00036.8         Access: Closed Access Read More

Author(s): Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge

DOI: 10.5958/0975-4377.2018.00032.0         Access: Closed Access Read More

Author(s): Ch. Anupama, P. Padmakumari, K. Abbulu, Arti Mohan, A. Ppratyusha

DOI:         Access: Open Access Read More

Author(s): Priyanka Choudhury, Pulak Deb, Suvakanta Dash

DOI: 10.5958/0975-4377.2016.00025.2         Access: Open Access Read More

Author(s): Prithviraj Chakraborty, Kumar Suresh, Veera Garg , Anu Goyal

DOI:         Access: Open Access Read More

Author(s): Rahul K. Godge, Prakash N. Kendre, Mahendra A. Giri, Syed M. Zama, Syed N. Lateef

DOI:         Access: Open Access Read More

Author(s): PS Gangane, KG Mahajan, HS Sawarkar, RR Thenge, VS Adhao

DOI:         Access: Open Access Read More

Author(s): Maged Alwan Noman, Mahmood Albooryhi, Abduwaly Ahmad Sayf, Hussein Omer Kadi

DOI:         Access: Open Access Read More

Author(s): Ravi Kumar, Swati Patil, M. B. Patil, Sachin R. Patil, Mahesh S. Paschapur

DOI:         Access: Open Access Read More

Author(s): T. Mamatha, Md. Raheem, S. Imam Pasha, Md. Zubair.

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags