Author(s): Madhu Babu K., Kathirvel S.

Email(s): kathirvel2007@gmail.com

DOI: Not Available

Address: Madhu Babu K., Kathirvel S.*
Department of Pharmaceutical Analysis, Hindu College of Pharmacy, Amaravathi Road, Guntur, Andhra Pradesh – 522002
*Corresponding Author

Published In:   Volume - 4,      Issue - 6,     Year - 2012


ABSTRACT:
A simple, sensitive, accurate spectrophotometric method has been developed for the estimation of Tapentadol hydrochloride in bulk and pharmaceutical formulation. The method is based on the formation of blue colored chromogen with Folin-Ciocalteu reagent in the presence of NaOH and obeys beer’s law in the range of 5 - 35µg/mL exhibiting the maximum absorbance at 763nm. The limit of detection and quantification were found to be 0.76µg/mL and 2.33µg/mL respectively. The calibration curve demonstrated a linear relationship between the absorbance and concentration, with the correlation coefficient higher than 0.9999. The Regression Equation of the curve was Y=0.0248x-0.0436. The method was fully validated according to ICH guidelines.


Cite this article:
Madhu Babu K., Kathirvel S. Development and Validation of visible Spectrophotometric method of Tapentadol Hydrochloride in bulk and Pharmaceutical dosage form. Research J. Pharma. Dosage Forms and Tech. 2012; 4(6): 328-331.


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DOI: 10.5958/0975-4377 


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