Author(s): Prakash N Kendre, Syed N Lateef, Rahul K Godge, Mahendra A Giri, Bharat D Pagare, Ritesh D Patel

Email(s): prakashkendre@rediffmail.com prakashkendre@gmail.com

DOI: Not Available

Address: Prakash N Kendre*, Syed N Lateef, Rahul K Godge, Mahendra A Giri, Bharat D Pagare and Ritesh D Patel
Sanjivani College of Pharmaceutical Education and Research, Sahajanandnagar Kopargaon, Ahmednagar, (M.S.), India *Corresponding Author

Published In:   Volume - 1,      Issue - 2,     Year - 2009


ABSTRACT:
The objective of this study was to formulate and evaluate a matrix system for sustained and simultaneous delivery of two anti-asthmatic drugs Salbutamol sulphate and Theophylline which is often indicated for the management of asthma, their frequent dosing may reduce compliance, thus making prolonged release formulation necessary. The matrix tablets were prepared by wet granulation method using hydroxypropyl methylcellulose (HPMC K15M, K4M; HPC and Carbapol 934P) in various percentages. The granules showed satisfactory flow properties and compressibility. All the five tablet formulations showed acceptable pharmacotechnical properties and complied with the in-house specifications for tested parameters. The release rate could efficiently be modified by varying the matrix forming polymer, the use of polymer blends and the addition of water soluble or water insoluble fillers (such as dicalcium phosphate, lactose or mannitol). The tablets swelled and eroded upon contact with release medium. Fitting the in-vitro drug release data to Korsmeyer equation indicated that diffusion along with erosion could be the mechanism of drug release.


Cite this article:
Prakash N Kendre, Syed N Lateef, Rahul K Godge, Mahendra A Giri, Bharat D Pagare , Ritesh D Patel. Formulation and in vitro-in vivo Evaluation of Theophyline and Salbutamol Sulphate Sustained Release Tablets. Research J. Pharma. Dosage Forms and Tech. 2009; 1(2): 103-107 .

Cite(Electronic):
Prakash N Kendre, Syed N Lateef, Rahul K Godge, Mahendra A Giri, Bharat D Pagare , Ritesh D Patel. Formulation and in vitro-in vivo Evaluation of Theophyline and Salbutamol Sulphate Sustained Release Tablets. Research J. Pharma. Dosage Forms and Tech. 2009; 1(2): 103-107 .   Available on: https://rjpdft.com/AbstractView.aspx?PID=2009-1-2-9


Recomonded Articles:

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Varsha R. Sandhan, S.B. Gondkar, R. B. Saudagar

DOI:         Access: Open Access Read More

Author(s): Akelesh T., R. Ramya, Venkatesh. P., Divya Jacob , R. Venkatnarayanan

DOI:         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8         Access: Open Access Read More

Author(s): Debjit Bhowmik, Amrendra Singh , Praveen Khirwadkar, Nishi Shukla, Vikas Kumar Chaudhari

DOI: 10.5958/0975-4377.2016.00027.6         Access: Open Access Read More

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI:         Access: Open Access Read More

Author(s): Amit K. Jain, Rajput Rammulrajsinh, Pradeep Agrawal, Kinal patel

DOI:         Access: Open Access Read More

Author(s): Bhoyar PK, Biyani DM, Shahare HV, Ikhar PK,Borkar VS

DOI:         Access: Open Access Read More

Author(s): NM Bhopale, HS Sawarkar, MB Narkhede, NV Thorat, MR Bhise, SS Khadabadi

DOI:         Access: Open Access Read More

Author(s): Viswanadham Manasa, K.Vanitha, M. Venkataswamy, P. Prabhakar, Alluri Ramesh

DOI: 10.5958/0975-4377.2016.00002.1         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2018.00036.8         Access: Open Access Read More

Author(s): Janmajoy Banerjee, H. Padmalatha, Korra Ramesh, Ranabir Chanda

DOI: 10.5958/0975-4377.2018.00026.5         Access: Open Access Read More

Author(s): Choudhury A, Dash SK , Roy A, Bahadur S, Saha S, Das S

DOI:         Access: Open Access Read More

Author(s): Sarita Garg, Meenakshi Bhatia, Pradeep Kumar

DOI:         Access: Open Access Read More

Author(s): SM Sarode, G Vidya Sagar, MK Kale, Nimase PK, Kulkarni AP, Firke SD,Firke BM, Warke PD, Chaudhari MA

DOI:         Access: Open Access Read More

Author(s): Varun Dasari, Bahlul Z. Awen, Babu Rao Chandu, Mukkanti Khagga

DOI:         Access: Open Access Read More

Author(s): Ranabir Chanda , H. Padmalata 1 Venkatesh , Janmajoy Banerjee

DOI: 10.5958/0975-4377.2019.00009.0         Access: Open Access Read More

Author(s): Rahul K Godge, Stephen L Fernandes, Syed N Lateef, Abhijeet N Merekar, Prakash N Kendre

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags