Author(s): Sarita Garg, Meenakshi Bhatia, Pradeep Kumar

Email(s): pradeep.kumar@chitkara.edu.in

DOI: Not Available

Address: Sarita Garg1, Meenakshi Bhatia1 and Pradeep Kumar2*
1Division of Pharmaceutics, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, Haryana, India
2Chitkara College of Pharmacy, Chandigarh Patiala National Highway, Rajpura-140401, Patiala, Punjab, India
*Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2009


ABSTRACT:
The present study was undertaken to evaluate the effect of different viscosity grades of polyoxyethylene, their content level and the method of tablet preparation on the release profile of cephalexin trihydrate from matrix systems. Matrix tablets were prepared using Polyox N-10, Polyox N-80, Polyox N-60 K, Polyox 301 and Polyox 303 as rate-retarding agents by direct compression process. The release of drug from these hydrophillic matrices was studied over 12-hours in buffer media of pH 1.2. Statistically significant difference was found among the drug release profile from different matrices. The release kinetics was found to be governed by the type and content of hydrophillic materials in the matrix. Tablets granulated by PVP K-30 solution have higher hardness than those prepared by direct compression. However, drug release was not influenced by the method of tablet preparation. Formulations containing Polyox N-60K, Polyox 301 and Polyox 303 released 82%, 76% and 70% of the drug respectively, indicating that increasing viscosity can drastically reduce the release rate. Further, a decrease in polymer concentrations resulted a slight increase in thickness and friability, while a increase in polymer level resulted a increase in hardness and decrease in release rate. Numerical fits indicated that the formulations followed the Zero order release pattern which was further confirmed by the domination of super case-II transport in polyox tablets.


Cite this article:
Sarita Garg, Meenakshi Bhatia, Pradeep Kumar. Effect of Different Polyoxyethylene Matrices on Extended Release Formulation of Cephalexin Trihydrate. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):269-274 .


Recomonded Articles:

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI:         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6         Access: Open Access Read More

Author(s): R. K.V. Naga Sudha, V. Sai Kishore, CH. Venu Babu, E. Jitendranath

DOI: 10.5958/0975-4377.2015.00016.6         Access: Open Access Read More

Author(s): Debjit Bhowmik, Amrendra Singh , Praveen Khirwadkar, Nishi Shukla, Vikas Kumar Chaudhari

DOI: 10.5958/0975-4377.2016.00027.6         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI:         Access: Open Access Read More

Author(s): Praveen Kumar Uppala, K. Atchuta Kumar, Murali Krishna, U. Upendra Rao

DOI: 10.5958/0975-4377.2016.00039.2         Access: Open Access Read More

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8         Access: Open Access Read More

Author(s): V Ganesan, Nilesh P Tekade, Nitin S Bhajipale, Durgesh R Dewade, Raju R Thenge

DOI:         Access: Open Access Read More

Author(s): B. Saraswathi, R. Jagadeesh Reddy, P. Swathi, G. Manasa

DOI: 10.5958/0975-4377.2017.00025.8         Access: Open Access Read More

Author(s): V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren

DOI:         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2018.00036.8         Access: Closed Access Read More

Author(s): Manish P Patel, MM Patel, KN Patel, DR Patel,UL Patel

DOI:         Access: Open Access Read More

Author(s): Desale Kishor B. Darekar A.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00029.X         Access: Open Access Read More

Author(s): Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge

DOI: 10.5958/0975-4377.2018.00032.0         Access: Closed Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags