ABSTRACT:
Aquasomes are an innovative class of nanoparticulate carrier systems with significant potential in drug delivery. These three-layered, self-assembled structures consist of a solid-phase nanocrystalline core coated with an oligomeric film, onto which bioactive molecules are adsorbed. The unique water-like properties of aquasomes protect and preserve delicate biological molecules, ensuring conformational integrity and high surface exposure. This characteristic makes them particularly effective in delivering proteins, peptides, genes, and vaccines to specific locations within the body. The core materials, such as calcium phosphate, nanocrystalline carbon ceramics, and tin oxide, support the stability and bioactivity of the loaded drugs. Aquasomes are assembled through non-covalent and ionic bonding, and their structural stability is maintained by interactions among charged groups, hydrogen bonding, and van der Waals forces. These nanoparticles offer a promising delivery solution for drugs facing challenges like chemical instability, low absorption, and significant side effects. Applications of aquasomes in protein and peptide delivery, gene therapy, vaccine delivery, and cancer therapy have demonstrated their versatility and efficiency. Despite their potential, challenges such as controlled drug release and specific targeting need further exploration. Overall, aquasomes represent a fusion of principles from food chemistry, biophysics, and microbiology, offering a robust platform for the targeted and effective delivery of various bioactive molecules.
Cite this article:
Shaikh Arbaz Ajaz, Imran Kalam, Quazi Majaz. A Review Article on Aquasome. Research Journal of Pharmaceutical Dosage Forms and Technology. 2024; 16(4):343-9. doi: 10.52711/0975-4377.2024.00053
Cite(Electronic):
Shaikh Arbaz Ajaz, Imran Kalam, Quazi Majaz. A Review Article on Aquasome. Research Journal of Pharmaceutical Dosage Forms and Technology. 2024; 16(4):343-9. doi: 10.52711/0975-4377.2024.00053 Available on: https://rjpdft.com/AbstractView.aspx?PID=2024-16-4-7
REFERENCES:
1. Vishal Sutariya And Parth Patel. Aquasomes: A Novel Carrier for Drug Delivery. IJPSR. 2012: 3(3): 688 -694.
2. Sanjay S. Jain, Pramod S. Jagtap, Neha M. Dand, Kisan R. Jadhav and Vilasrao J. Kadam. Aquasomes: A Novel Drug Carrier. Journal Of Applied Pharmaceutical Science. 2012; 2(1); 184-192
3. Ajay Kumar Gupta, Diptee Gupta, Vedant Gupta Aquasomes: A Self- Assembled Nano-Particulate Carrier System. International Journal of Current Research and Review. 2021; 13(4): 44-52.
4. Marakanam S. Umashankar, Rajesh K. Sachdeva, Monica Gulati.Aquasomes: A Promising Carrier for Peptides and Protein Delivery. Nanomedicine: Nanotechnology, Biology, and Medicine. 2010; 6: 419–426
5. Snehal Patel, Chintan Aundhia, Avinash Seth, Nirmal Shah, Kartik Pandya and Darshika Patel. Aquasomes: A Novel Approach in Drug Carrier System. EJPMR. 2016; 3(9): 198-201.
6. Prashant Popat Jadhav, Nagesh Hanmantrao Aloorkar. A Review on Aquasomes. IJCRT. 2021; 9(5): 537-539.
7. Syeda Ruhina Anjum, K.V. Ratnamaala. Aquasomes: A Nano- Particulate Carrier System. International Journal Of Innovative Research In Technology. 2021; 8(4):532-535.
8. Junju Mohan Kumar, Voleti Vijaya Kumar, Rayaprolu Mounica, Sai Padmini Bolla, M. Pavani. Aquasomes -The Best Carriers For Protein And Peptide Delivery. Asian Journal Of Pharmaceutical Research and Development. 2013; 1(4): 16-23.
9. Remya S. B, Subash Chandran M. P., Prasobh G. R., Aparna P. Aquasomes- A Newer Drug Delivery System. IAJPS. 2019; 6(11): 14712-14719.
10. Abhilash Kutlehria, Peeyush Kaushik, Shaveta Sharma, Arvind Kaur. Aquasomes As A Carrier System For Oral Delivery Of Bromelain. International Research Journal of Pharmacy. 2018; 9(8):123-129.
11. Ajay Kumar Gupta, Diptee Gupta, Vedant Gupta Aquasomes: A Self- Assembled Nano-Particulate Carrier System. International Journal of Current Research and Review. 2021; 13(4): 44-52.
12. Kitawat Santosh, Saxena A. Aquasomes: A Novel Drug Carrier System for Bioactive Molecules. Asio Journal of Pharmaceutical & Herbal Medicines Research (Asio-JPHMR). 2015; 1(1): 1-4.
13. Marakanam S. Umashankar, Rajesh K. Sachdeva, Monica Gulati.Aquasomes: A Promising Carrier for Peptides and Protein Delivery. Nanomedicine: Nanotechnology, Biology, and Medicine. 2010; 6: 419–426
14. Amol D. Gholap, Santosh S. Borude, Anand M. Mahajan. Aquasomes: A Potetial Drug Delivery Carrier. Pharmacologyonline. 2011; E 3: 230-237.
15. Jadhav Shubham Sambhaji, Tushar Gaikwad. Aquasomes: A Novel Drug Carrier System. International Journal Of Research Publication And Reviews. 2022; 3(6): 1014-1017.
16. T. Srilakshmi, V.T. Iswariya, K. Vignesh, M. Aishwarya, SK. Rizwana, T. Ramarao. Aquasomes: A Novel Drug Delivery Approach. 2022; 21(12): 2710-2716.