Author(s): Taufik Mulla, Mrunali Nemade, Tahoora Ansari, Bhumika Parmar, Drashti Dave

Email(s): mullataufik@gmail.com

DOI: 10.52711/0975-4377.2024.00026   

Address: Taufik Mulla1*, Mrunali Nemade2, Tahoora Ansari3, Bhumika Parmar4, Drashti Dave5
1,5Krishna School of Pharmacy and Research, A Constituent College of Drs. Kiran and Pallavi Patel Global Univeristy, Varnama, Vadodara, Gujarat. India.
2,4Institute of Pharmaceutical Sciences, Parul University, Vadodara, Gujarat. India.
3Allana College of Pharmacy, A Constituent College of Dr. P.A. Inamdar University, Pune, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 2,     Year - 2024


ABSTRACT:
Omeprazole, a widely prescribed proton pump inhibitor renowned for its effectiveness in treating gastrointestinal disorders, faces limitations in its therapeutic potential due to its poor aqueous solubility, resulting in suboptimal bioavailability. This article conducts a thorough review of recent advancements in strategies aimed at enhancing omeprazole's solubility. The evaluation encompasses various techniques, including solid dispersion technology, nanosizing, cyclodextrin complexation, salt formation, and micellar delivery systems, all aimed at improving the solubility and overall therapeutic performance of omeprazole. The review addresses existing challenges and outlines future prospects, with a specific focus on the translation of solubility enhancement strategies from laboratory settings to commercial production. The comprehensive insights presented contribute to a profound understanding of the recent advancements in solubility enhancement of omeprazole, fostering the development of more efficient and patient-friendly formulations for improved therapeutic outcomes.


Cite this article:
Taufik Mulla, Mrunali Nemade, Tahoora Ansari, Bhumika Parmar, Drashti Dave. Advancements in Solubility Enhancement of Omeprazole: A Comprehensive Review. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(2):163-2. doi: 10.52711/0975-4377.2024.00026

Cite(Electronic):
Taufik Mulla, Mrunali Nemade, Tahoora Ansari, Bhumika Parmar, Drashti Dave. Advancements in Solubility Enhancement of Omeprazole: A Comprehensive Review. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(2):163-2. doi: 10.52711/0975-4377.2024.00026   Available on: https://rjpdft.com/AbstractView.aspx?PID=2024-16-2-7


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