Formulation and Evaluation of Orodispersible Tablet of Cefixime trihydrate by using Fenugreek Mucilage as a Superdisintegrant

Rihan Jawed; Wajid Ahmad

doi:10.52711/0975-4377.2022.00004

Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)

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Formulation and Evaluation of Orodispersible Tablet of Cefixime trihydrate by using Fenugreek Mucilage as a Superdisintegrant

Author(s): Rihan Jawed, Wajid Ahmad

Email(s): Email ID Not Available

DOI: 10.52711/0975-4377.2022.00004

Address: Rihan Jawed*, Wajid Ahmad
Department of Pharmaceutics, Institute of Pharmacy, Angola, Turkey.
*Corresponding Author

Published In: Volume - 14, Issue - 1, Year - 2022

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ABSTRACT:
Current research is focused on formulation and evaluation of natural gum based fast dissolving tablet of Cefixime trihydrate by applying 32 factorial designs for the improvement of the drug absorption. Direct compression method was used. Two factors as independent variable (x1) Fenugreek mucilage(x2) sodium saccharin glycolate were taken with three level (+1, 0,-1). The level two factors were selected on basis of preliminary experiments conducted and their effect on dependent variable (disintegration time) was estimated. Formulated tablets were evaluated for parameters in which the values were found to be in the range of hardness 2.1-2.6 kg/cm2, thickness 2.227-2.296 mm, weight variance 182-196 mg, wetting time 58-68 seconds, water absorption ratio 0.1628-0.2439, disintegration time 56 sec – 9 min, and friability 0.53-0.68 %. The software design expert (11.0) was used for getting experimental design, modeling the response surface and calculating the static evaluation. The tablet parameters tests of formulation (F1 to F10) were observed within prescribe limit. Disintegration time observed 56 seconds, % cumulative drug release 88.79 % to 98.90 %. Batch F6 was observed as promising batch.

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Cite this article:
Rihan Jawed, Wajid Ahmad. Formulation and Evaluation of Orodispersible Tablet of Cefixime trihydrate by using Fenugreek Mucilage as a Superdisintegrant. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(1):23-8. doi: 10.52711/0975-4377.2022.00004

Cite(Electronic):
Rihan Jawed, Wajid Ahmad. Formulation and Evaluation of Orodispersible Tablet of Cefixime trihydrate by using Fenugreek Mucilage as a Superdisintegrant. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(1):23-8. doi: 10.52711/0975-4377.2022.00004 Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-1-4

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DOI: 10.5958/0975-4377