Author(s): Rihan Jawed, Wajid Ahmad

Email(s): Email ID Not Available

DOI: 10.52711/0975-4377.2022.00004   

Address: Rihan Jawed*, Wajid Ahmad
Department of Pharmaceutics, Institute of Pharmacy, Angola, Turkey.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2022


ABSTRACT:
Current research is focused on formulation and evaluation of natural gum based fast dissolving tablet of Cefixime trihydrate by applying 32 factorial designs for the improvement of the drug absorption. Direct compression method was used. Two factors as independent variable (x1) Fenugreek mucilage(x2) sodium saccharin glycolate were taken with three level (+1, 0,-1). The level two factors were selected on basis of preliminary experiments conducted and their effect on dependent variable (disintegration time) was estimated. Formulated tablets were evaluated for parameters in which the values were found to be in the range of hardness 2.1-2.6 kg/cm2, thickness 2.227-2.296 mm, weight variance 182-196 mg, wetting time 58-68 seconds, water absorption ratio 0.1628-0.2439, disintegration time 56 sec – 9 min, and friability 0.53-0.68 %. The software design expert (11.0) was used for getting experimental design, modeling the response surface and calculating the static evaluation. The tablet parameters tests of formulation (F1 to F10) were observed within prescribe limit. Disintegration time observed 56 seconds, % cumulative drug release 88.79 % to 98.90 %. Batch F6 was observed as promising batch.


Cite this article:
Rihan Jawed, Wajid Ahmad. Formulation and Evaluation of Orodispersible Tablet of Cefixime trihydrate by using Fenugreek Mucilage as a Superdisintegrant. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(1):23-8. doi: 10.52711/0975-4377.2022.00004

Cite(Electronic):
Rihan Jawed, Wajid Ahmad. Formulation and Evaluation of Orodispersible Tablet of Cefixime trihydrate by using Fenugreek Mucilage as a Superdisintegrant. Research Journal of Pharmaceutical Dosage Forms and Technology.2022; 14(1):23-8. doi: 10.52711/0975-4377.2022.00004   Available on: https://rjpdft.com/AbstractView.aspx?PID=2022-14-1-4


REFERENCE:
1.    Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020;6(2):94-100.
2.    Rajesh A, Manmeet K, Sangeeta A. Formulation and evaluation of fast dissolving tablet of Pioglitazone. Research Journal of Pharmacy and Technology. 2012;5(6):817-21.
3.    Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
4.    Patel P, Kumar PA, Shah H, Patel N, Kheni P, Rao BS, Kulkarni SV, Babitha S. Formulation and Evaluation of Fast Dissolving Tablet of Telmisartan. Research Journal of Pharmacy and Technology. 2011;4(6):955-61.
5.    Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019;8(8):624-9.
6.    Madoria N, Maheshwari Y. Formulation, Optimization and Characterization of Fast Dissolving Tablet of Celecoxib. Research Journal of Pharmacy and Technology. 2012;5(8):1085-8.
7.    Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31;13(3):4942-51.
8.    Sharma S, Bharadwaj S, Gupta GD. Fast Dissolving Tablets of Promethazine Theoclate by Using Natural Superdisintegrants. Research Journal of Pharmacy and Technology. 2008;1(3):218-24.
9.    Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Cefixime trihydrate for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31;13(1):4745-52.
10.    Kumar K, Chopra H, Sharma GK. Formulation and evaluation of fast dissolving tablet of montelukast by using co-processed excipients. Research Journal of Pharmacy and Technology. 2019;12(11):5543-8.
11.    Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 18;14(3):1535-41.
12.    Mahesh PG, Raman SG. Formulation and Evaluation of Fast Dissolving Tablet of Prasugrel. Research Journal of Pharmacy and Technology. 2021 Aug 1;14(8):4077-9.
13.    Giri TK, Sa B. Formulation of rapidly disintegrating fast dissolving diazepam tablets using solid dispersions through a statistical approach. Research Journal of Pharmacy and Technology. 2010;3(4):1246-51.
14.    Deshmukh SS, Quazi A, Saraf A. Formulation and Evaluation of Fast Dissolving Tablets of Chlorpromazine Hydrochloride Using Novel Co-processed Superdisintegrants. Research Journal of Pharmacy and Technology. 2012;5(9):1235-40.
15.    Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal Of Pharmaceutical Education and Research. 2021 Jan 1;55(1):86-94.
16.    Ratnaparkhi MP, Karnawat GR, Andhale RS. Natural polymers in fast dissolving tablets. Research Journal of Pharmacy and Technology. 2021 May 1;14(5):2859-66.
17.    Dave V, Yadav RB, Ahuja R, Yadav S. Formulation design and optimization of novel fast dissolving tablet of chlorpheniramine maleate by using lyophilization techniques. Bulletin of Faculty of Pharmacy, Cairo University. 2017 Jun 1;55(1):31-9.
18.    Lal M, Priddy S, Bourgeois L, Walker R, Pebley W, Brown J, Desai J, Darsley MJ, Kristensen D, Chen D. Development of a fast-dissolving tablet formulation of a live attenuated enterotoxigenic E. coli vaccine candidate. Vaccine. 2013 Oct 1;31(42):4759-64.
19.    Antonijoan R, García-Gea C, Puntes M, Pérez J, Esbrí R, Serra C, Fortea J, Barbanoj MJ. Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adults. Clinical therapeutics. 2007 May 1;29(5):814-22.
20.    Cilurzo F, Cupone IE, Minghetti P, Selmin F, Montanari L. Fast dissolving films made of maltodextrins. European Journal of Pharmaceutics and Biopharmaceutics. 2008 Nov 1;70(3):895-900.

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DOI: 10.5958/0975-4377 


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