Formulation and Evaluation of Israpidine Extended Release Matrix Tablets

Praveen Kumar Uppala; K. Atchuta Kumar; Murali Krishna; U. Upendra Rao

doi:10.5958/0975-4377.2016.00039.2

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Formulation and Evaluation of Israpidine Extended Release Matrix Tablets

Author(s): Praveen Kumar Uppala, K. Atchuta Kumar, Murali Krishna, U. Upendra Rao

Email(s): praveen.chintu32@gmail.com

DOI: 10.5958/0975-4377.2016.00039.2

Address: Praveen Kumar Uppala*, K. Atchuta Kumar, Murali Krishna, U. Upendra Rao
Bhaskara Institute of Pharmacy, Affiliated to Andhra University, Vizianagaram
*Corresponding Author

Published In: Volume - 8, Issue - 4, Year - 2016

View HTML

View PDF

ABSTRACT:
The purpose of this study was to formulate and evaluate an efficient Isradipine extended release matrix tablets designed to provide 24 hours drug release profile using varying proportion of hydrophilic polymers viz; Lactose monohydrate and HEC as matrix-forming material. Prepared matrix tablets showed satisfactory physicochemical properties where drug content was 98.24% to 101.06 %, thickness was 3.33 mm to 3.55 mm, hardness was 7.52±0.171 to 8.94±0.285 kg/cm2 , friability was less than 1% and % weight variation was within the standard pharmacopoeial limits of ±7.5% of the weight. Mathematical analysis of the release kinetics of the optimized formulation (F15) was best fitted in zero order kinetics (R2 = 0.9743). The dissolution profiles of formulation F15 and innovator product in multi media were compared in pH 4.5 acetate buffer, pH 6.8 phosphate buffer, 0.1N HCl respectively. The stability data reveals that the F15 showed a negligible change in drug content after storage in various conditions for two months according to ICH guidelines.

Keywords:

Cite this article:
Praveen Kumar Uppala, K. Atchuta Kumar, Murali Krishna, U. Upendra Rao. Formulation and Evaluation of Israpidine Extended Release Matrix Tablets. Res. J. Pharm. Dosage Form. & Tech. 2016; 8(4): 277-291. doi: 10.5958/0975-4377.2016.00039.2

Recomonded Articles:

Formulation, Evaluation of Clotrimazole Vaginal Suppository

Author(s): V. S. Parmar, S.C. Shivhare

DOI: Access: Open Access Read More

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

Formulation and In-Vitro Evaluation of a Sustained Release Matrix Tablet of Telmisatan

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/0975-4377.2017.00004.0 Access: Open Access Read More

Enhancement of Solubility of Poorly Water Soluble Drug (Allopurinol) Through Solid Dispersion

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI: Access: Open Access Read More

Comparative Standardization of Two Marketed Preparation of Gulwel churna

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2 Access: Open Access Read More

Formulation and Evaluation of Sustained Release Matrix Tablets Containing Aceclofenac and Paracetamol

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/0975-4377.2017.00010.6 Access: Open Access Read More

Formulation Development and Evaluation of Buccal Patches of Aceclofenac for Gingivitis

Author(s): Puja Saha, Pratik Swarup Das

DOI: 10.5958/0975-4377.2017.00026.X Access: Open Access Read More

Formulation and Evaluation of Methyl Phenidate Sustained Release Tablets

Author(s): Debjit Bhowmik, Amrendra Singh , Praveen Khirwadkar, Nishi Shukla, Vikas Kumar Chaudhari

DOI: 10.5958/0975-4377.2016.00027.6 Access: Open Access Read More

Formulation and Evaluation of Telmisartan Fast Dissolving Tablets by Direct Compression Method

Author(s): Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2017.00022.2 Access: Open Access Read More

In vitro Dissolution Studies on Commercial Brands Containing Immediate Release Pioglitazone and Metformin Hydrochloride Extended Release Tablets

Author(s): K. Soumya, S. Susanna, T.E.G.K. Murthy

DOI: 10.5958/0975-4377.2017.00003.9 Access: Open Access Read More

Effect of pH on Dissolution Profile of Atenolol Sustained Release Matrix Tablets

Author(s): Masheer Ahmed Khan

DOI: Access: Open Access Read More

Formulation and Evaluation of Transdermal Patch of Aceclofenac

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI: Access: Open Access Read More

In-Vitro Release Kinetic Study of Mosapride Citrate Dihydrate from Sustained Release Matrix Tablet Containing Two Different Viscosity Grades of HPMC

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI: Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377