Author(s): Farah Hamad Farah, Omer Ali Attef, Abdul-Azim Ahmed Ali

Email(s): f.hamad@ajman.ac.ae. , attef@hotmail.com , ajac.azim@ajman.ac.ae.

DOI: 10.5958/0975-4377.2015.00001.4   

Address: Farah Hamad Farah1*, Omer Ali Attef2 and Abdul-Azim Ahmed Ali3
1Department of Pharmaceutics, College of Pharmacy and Health Sciences, Ajman University of Science and Technology, UAE.
2Department of Pharmaceutical Chemistry, College of Pharmacy and Health Sciences, Ajman University of Science and Technology, UAE
3Department of Pharmaceutics, College of Pharmacy and Health Sciences, Ajman University of Science and Technology, UAE,
*Corresponding Author

Published In:   Volume - 7,      Issue - 1,     Year - 2015


ABSTRACT:
The influence of khat on both in-vitro and in-vivo availability of tetracycline-HCl has been evaluated. The in-vitro availability data have reflected a statistically significant interaction between khat extract and tetracycline-HCl in two buffer solutions simulating intestinal and gastric media (phosphate buffer-pH 7 and 0.1 HCl-pH 1.2 respectively). In the in-vivo availability studies, ten adult healthy Yemeni volunteers participated. The obtained in-vivo availability data indicated a statistically significant reduction in most pharmacokinetics parameters. A statistically significant % reduction in the maximum plasma tetracycline-HCl concentration (Cmax) and absorption rate constant (Ka) as well as a significant enhancement of time to reach the peak plasma concentration (Tmax), were observed as a result of taking tetracycline-HCl just before khat chewing (trial B) and more pronounce during khat chewing (trial D) compared to the control (trial C). In addition a statistically significant % reduction in area under curve (AUC0?8) has been observed reflecting a reduction in the extent of in-vivo tetracycline-HCl availability as a result of khat chewing. Statistically significant % reductions in the biologic half-life (t½) and elimination rate constant (Kel) were also observed.The reduction in tetracycline-HCl concentration when mixed with khat extract, as shown by in-vitro data, may reflect a possible formation of tetracycline-HCl complexes with one or more of khat constituents. The reduction in the rate and extent of in-vivo tetracycline-HCl availability as a result of khat chewing, may be due to the possible formation of non-absorbable tetracycline-HCl complexes with one or more of khat constituents or possible delaying of gastric emptying induced by khat that may prolong the resident time of tetracycline-HCl in the stomach leading to its possible degradation into the less antimicrobial active form epitetracycline.


Cite this article:
Farah Hamad Farah, Omer Ali Attef, Abdul-Azim Ahmed Ali. The Influence of Khat on the In-vitro and In-vivo availability of Tetracycline-HCl. Res. J. Pharm. Dosage Form. & Tech. 7(1): Jan.-Mar. 2015; Page 01-06. doi: 10.5958/0975-4377.2015.00001.4


Recomonded Articles:

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Masheer Ahmed Khan

DOI:         Access: Open Access Read More

Author(s): Nakkala Balaji , V. Sai Kishore , Kasani Hari Krishna Gouda

DOI:         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Shoaib Ahmad

DOI: 10.5958/0975-4377.2016.00041.0         Access: Open Access Read More

Author(s): Nisha Nair, Amrita Thakur, Mukta Agrawal, Juhi Thakur,Shubhangi Gupta, Bharti Sahu, Devendra kumar, Indu Rai, Jaya Sonkar, Kalyani Sahu, Kuldeep, Kailash Kumar, Muktanand, Nidhi Kaushik, Omkar Sahu, Somsunder Sahu, Umesh Kumar, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0975-4377.2018.00017.4         Access: Open Access Read More

Author(s): V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren

DOI:         Access: Open Access Read More

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0         Access: Open Access Read More

Author(s): Patil GB, Deshmukh PK, Belgamwar VS

DOI:         Access: Open Access Read More

Author(s): Amrita Thakur, Nisha Nair, Mukta Agrawal, Yashi Thakur, Juhi Thakur,TemanNirmalkar,VedPrakashVerma,Vibhash Gupta,Vivek Singh Yadav,KalpanaMahilange, PoojaMahant, PritamYadav, Deepak Patel, Dinesh Khamari, JyotsanaMeshram, RakeshSahu, TarunGhatode, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0975-4377.2018.00018.6         Access: Open Access Read More

Author(s): Selvaraju K., Vengadesh Prabhu K., Karthick K., Padma Preetha J., Arul Kumaran K.S.G.

DOI:         Access: Open Access Read More

Author(s): Patel Chirag J., Asija Sangeeta, Patel Pinkesh, Mangukia Dhruv, Satyanand Tyagi

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags