Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)


Submit Article

The Influence of Khat on the In-vitro and In-vivo availability of Tetracycline-HCl

Author(s): Farah Hamad Farah, Omer Ali Attef, Abdul-Azim Ahmed Ali

Email(s): f.hamad@ajman.ac.ae. , attef@hotmail.com , ajac.azim@ajman.ac.ae.

DOI: 10.5958/0975-4377.2015.00001.4   

Address: Farah Hamad Farah1*, Omer Ali Attef2 and Abdul-Azim Ahmed Ali3
1Department of Pharmaceutics, College of Pharmacy and Health Sciences, Ajman University of Science and Technology, UAE.
2Department of Pharmaceutical Chemistry, College of Pharmacy and Health Sciences, Ajman University of Science and Technology, UAE
3Department of Pharmaceutics, College of Pharmacy and Health Sciences, Ajman University of Science and Technology, UAE,
*Corresponding Author

Published In:   Volume - 7,      Issue - 1,     Year - 2015

 View HTML        View PDF

ABSTRACT:
The influence of khat on both in-vitro and in-vivo availability of tetracycline-HCl has been evaluated. The in-vitro availability data have reflected a statistically significant interaction between khat extract and tetracycline-HCl in two buffer solutions simulating intestinal and gastric media (phosphate buffer-pH 7 and 0.1 HCl-pH 1.2 respectively). In the in-vivo availability studies, ten adult healthy Yemeni volunteers participated. The obtained in-vivo availability data indicated a statistically significant reduction in most pharmacokinetics parameters. A statistically significant % reduction in the maximum plasma tetracycline-HCl concentration (Cmax) and absorption rate constant (Ka) as well as a significant enhancement of time to reach the peak plasma concentration (Tmax), were observed as a result of taking tetracycline-HCl just before khat chewing (trial B) and more pronounce during khat chewing (trial D) compared to the control (trial C). In addition a statistically significant % reduction in area under curve (AUC0?8) has been observed reflecting a reduction in the extent of in-vivo tetracycline-HCl availability as a result of khat chewing. Statistically significant % reductions in the biologic half-life (t½) and elimination rate constant (Kel) were also observed.The reduction in tetracycline-HCl concentration when mixed with khat extract, as shown by in-vitro data, may reflect a possible formation of tetracycline-HCl complexes with one or more of khat constituents. The reduction in the rate and extent of in-vivo tetracycline-HCl availability as a result of khat chewing, may be due to the possible formation of non-absorbable tetracycline-HCl complexes with one or more of khat constituents or possible delaying of gastric emptying induced by khat that may prolong the resident time of tetracycline-HCl in the stomach leading to its possible degradation into the less antimicrobial active form epitetracycline.


Keywords:

Cite this article:
Farah Hamad Farah, Omer Ali Attef, Abdul-Azim Ahmed Ali. The Influence of Khat on the In-vitro and In-vivo availability of Tetracycline-HCl. Res. J. Pharm. Dosage Form. & Tech. 7(1): Jan.-Mar. 2015; Page 01-06. doi: 10.5958/0975-4377.2015.00001.4

Cite(Electronic):
Farah Hamad Farah, Omer Ali Attef, Abdul-Azim Ahmed Ali. The Influence of Khat on the In-vitro and In-vivo availability of Tetracycline-HCl. Res. J. Pharm. Dosage Form. & Tech. 7(1): Jan.-Mar. 2015; Page 01-06. doi: 10.5958/0975-4377.2015.00001.4   Available on: https://rjpdft.com/AbstractView.aspx?PID=2015-7-1-1


Recomonded Articles:

Formulation and Evaluation of Stable Montelukast Sodium Sublingual Tablet by using Lyophilization Technique

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Transdermal Drug Delivery System of Antidiabetic Drugs: A Review

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Enhancement of Solubility of Poorly Water Soluble Drug (Allopurinol) Through Solid Dispersion

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Influence of Different Beverages on Disintegration Behavior of Pain Reliever Immediate Release Formulations

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Buccal Patch of Saxagliptin Hydrochloride

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Formulation Development and Evaluation of Buccal Patches of Aceclofenac for Gingivitis

Author(s): Puja Saha, Pratik Swarup Das

DOI: 10.5958/0975-4377.2017.00026.X         Access: Open Access Read More

Self Microemulsifying Drug Delivery System (SMEDDS): A Novel Approach to Improve the Therapeutic Efficacy of Orally Administered Drug

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Effect of pH on Dissolution Profile of Atenolol Sustained Release Matrix Tablets

Author(s): Masheer Ahmed Khan

DOI:         Access: Open Access Read More

Enzyme Immobilization: A Bridge of Understanding between Biotechnology and Pharmacy

Author(s): Nisha Nair, Amrita Thakur, Mukta Agrawal, Juhi Thakur,Shubhangi Gupta, Bharti Sahu, Devendra kumar, Indu Rai, Jaya Sonkar, Kalyani Sahu, Kuldeep, Kailash Kumar, Muktanand, Nidhi Kaushik, Omkar Sahu, Somsunder Sahu, Umesh Kumar, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0975-4377.2018.00017.4         Access: Open Access Read More

Formulation and Evaluation of Floating Matrix Tablets of Acyclovir using 32 Factorial Design

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0         Access: Open Access Read More

Design and Development of Fast Dissolving Tablets of Glibenclamide

Author(s): V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren

DOI:         Access: Open Access Read More

Formulation and Evaluation of Simvastatin Solid Dispersions for Dissolution Rate Enhancement

Author(s): Nakkala Balaji , V. Sai Kishore , Kasani Hari Krishna Gouda

DOI:         Access: Open Access Read More

Ambroxol Lozenges: Introduction and Recent Advances

Author(s): Shoaib Ahmad

DOI: 10.5958/0975-4377.2016.00041.0         Access: Open Access Read More

Glimepiride Micro balloons: A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Author(s): Rutuja R. Shah, Rutuja S. Shah, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00030.1         Access: Open Access Read More

Formulation and Evaluation of mucoadhesive buccal patches of Terbutaline Sulphate

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Formulation Development and Evaluation of Floating Drug Delivery System for H2-Blocker Drug (Roxatidine Acetate)

Author(s): Rajesh Mujoriya, Dharmendra Mundhada, Sangram Pawar

DOI: 10.5958/0975-4377.2016.00026.4         Access: Open Access Read More

Fast Dissolving Tablets-An Updated Review

Author(s): Ashok Thulluru, K. Saravanakumar, Ch. S. Phani Kumar, Nawaz Mahammed, D. Sreeja, G. Bhuvanesh, N. Vamsi Chowdary, Nayeema Khowser Shaik

DOI: 10.5958/0975-4377.2019.00049.1         Access: Open Access Read More

Formulation Development of Ketoconazole Ophthalmic Formulation

Author(s): Varsha R. Sandhan, S.B. Gondkar, R. B. Saudagar

DOI:         Access: Open Access Read More

Medicated Chewing Gum: A Modern Era of Novel Drug Delivery System

Author(s): Patel Chirag J., Asija Sangeeta, Patel Pinkesh, Mangukia Dhruv, Satyanand Tyagi

DOI:         Access: Open Access Read More

Studies on Occlusion Complexes of Aceclofenac with β-Cyclodextrin and Hydroxypropyl -β- Cyclodextrin

Author(s): Patil GB, Deshmukh PK, Belgamwar VS

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 

Quick Links

Latest Issues

Popular Articles


Recent Articles



Preparation and Evaluation of Yohimbine Hydrochloride Agglomerates by Crystallo Co-Agglomeration technique
Types of Transdermal Drug Delivery Systems: A Literature Report of the Past decade
A Detailed Review on Fast Dissolving Niosomal Films for Sublingual Drug Delivery
Novel Topical Drug Delivery System: Microemulgel - A Review
Review on Orodispersible Tablet: Recent Trends of Manufacturing of Orodispersible Tablet
A Review on various methods for the Cross-linking of Polymers
A Glance at the Literature review on Buccal films
Development and Validation of Stability Indicating RP-HPLC Method for Estimation of Levamisole HCl in Bulk and Tablet Dosage Form
Development and Characterization of Lipospheres Containing Repaglinide
A Study on Formulation and Evaluation of Herbal Chyawanprash Chocolate
To Study the effect of Cross linking of Sodium Alginate on the Rate of Drug Release
Development and Evaluation of Transdermal patches of Piperine hydrochloride
Formulation and Evaluation of Chewable Oral Jelly containing Zolmitriptan hydrochloride
In vitro Evaluation of Floating Microspheres of Gabapentin by Solvent Evaporation Method
Herbal extracts in Novel Drug Delivery System: A Magical Combo: A Brief Review
Development and Evaluation of Nanosuspension of Albendazole by Nanoprecipitation
A Review on Drug Penetration Enhancer
A concise review on analytical profile of chlorthalidone
Ethosomes: A Novel Vesicular Innovation to Enhance Transdermal Delivery of Drugs
A Review on HPLC Method Development and Validation for Gliptin Class: New Oral Antidiabetic Agents

Tags


About Journal

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 308
Yesterday: 353
Total: 414613