The brain in delicious organ of the body so, it is necessary to protect them. Also it a complex system of the body. Although various research has been done for patient suffering from the fatal CNS disease such as brain tumor, HIV encephalopathy, epilepsy, cerebrovascular disease, neurodegenerative disorders. In clinical experiment it failure to treat properly due to lack of potency but rather method by which deliver a particular dosage form to that part. Treating CNS is particular challenging due to present of formidable barrier such as BBB, is a major bottleneck in drug delivery to brain this can be involve tight junction between endothelial cell result in very high endothelial electric resistance then other body tissue that can be effect on the uptake of drug to brain. In present review various strategies to enhance transport of drug to CNS like, carrier mediated transport, receptor mediated transport, BBB distruption, cell penetrating peptide and targeting therapy, intracerebral, intracerebroventricular and intransal delivery via olfactory and neuronal pathway. In this review brief description of BBB and nasal anatomy can be involve. Among various strategies intra nasal delivery most prefer way to improving delivery of drug via olfactory region, due to highly permeation rate of nasal mucosa and also rapid absorption of drug to produce onset of action high. In that brief description of all possible factor for nasal drug delivery can be involve.
Cite this article:
Manoj K. Baladaniya, Ankit P. Karkar, Nirav V. Patel.. Review on Drug Delivery to the Central Nervous System: Novel Approaches. Res. J. Pharm. Dosage Form. and Tech. 6(4):Oct.- Dec.2014; Page 253-266.