Derivatization Spectroscopy-A Challenging Era for Analysis of Drug.

Mohamad Azhar A. Patwekar; V.R. Salunkhe

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Derivatization Spectroscopy-A Challenging Era for Analysis of Drug.

Author(s): Mohamad Azhar A. Patwekar, V.R. Salunkhe

Email(s): azharp4u@gmail.com.

DOI: Not Available

Address: Mohamad Azhar A. Patwekar*, V.R. Salunkhe
Rajarambapu College of Pharmacy, Kasegaon, Dist:Sangli (M.S)
*Corresponding Author:

Published In: Volume - 5, Issue - 5, Year - 2013

View HTML

View PDF

ABSTRACT:
Derivatization is the process by which a compound is chemically changed, producing a new compound that has properties more amenable to a particular analytical method. Derivatization spectroscopy can be used for preparation of new derivatives from original one which can be detect in UV region. Several methods like nitration, sulphonation, methylation, esterification, acetylation and diazotization has been used for formation of new derivative which may be color or colorless and can be detected in UV region. Derivatization is an integral part of chemical analysis in many areas of chemistry such as medical, forensic, food science, and environmental disciplines. Derivatization enables the analyst to analyze a wide variety of compounds by GC, GC-MS, HPLC and LC-MS that were otherwise less volatile and unstable for these techniques. In general, analytical derivatization is employed for two reasons, to permit analysis of compounds with inadequate volatility or stability and to improve chromatographic behavior or detectability. The primary use of derivatization is the chemical modification of a compound by derivatizing its functional group (e.g., O-H, COOH, N-H, and S-H) to promote the use of chromatographic analysis. The underivatized compounds can demonstrate poor chromatographic behavior, insufficient volatility, and poor thermal stability or have inadequate detector response. By chemically modifying these compounds into derivatives they have properties amendable for chromatographic separation and accurate analysis.

Keywords:

Cite this article:
Mohamad Azhar A. Patwekar, V.R. Salunkhe. Derivatization Spectroscopy-A Challenging Era for Analysis of Drug.. Research J. Pharma. Dosage Forms and Tech. 2013; 5(5): 263-268.

Recomonded Articles:

Formulation, Evaluation of Clotrimazole Vaginal Suppository

Author(s): V. S. Parmar, S.C. Shivhare

DOI: Access: Open Access Read More

Pharmaceutical Suspensions: Pharmacist has the Very Best Possible Formulation for the Job at Hand.

Author(s): Praneta Desale

DOI: Access: Open Access Read More

Comparative Standardization of Two Marketed Preparation of Gulwel churna

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2 Access: Open Access Read More

Enzyme Immobilization: A Bridge of Understanding between Biotechnology and Pharmacy

Author(s): Nisha Nair, Amrita Thakur, Mukta Agrawal, Juhi Thakur,Shubhangi Gupta, Bharti Sahu, Devendra kumar, Indu Rai, Jaya Sonkar, Kalyani Sahu, Kuldeep, Kailash Kumar, Muktanand, Nidhi Kaushik, Omkar Sahu, Somsunder Sahu, Umesh Kumar, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0975-4377.2018.00017.4 Access: Open Access Read More

Co-Processed Excipients for Tabletting

Author(s): P. Lekshmi, K. Pramod, K.C. Ajithkumar

DOI: 10.5958/0975-4377.2016.00007.0 Access: Open Access Read More

Pharmaceutical Packaging Technology: A Brief Outline

Author(s): Pratik Swarup Das, Puja Saha1, Krishan, Rumpa Das

DOI: :10.5958/0975-4377.2018.00005.8 Access: Open Access Read More

Recent trends in role of superdisintegrants to formulation of solid oral dosage form

Author(s): Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2018.00036.8 Access: Closed Access Read More

Abuse Deterrent Opioid Formulations: A Review

Author(s): Suresh A Marnoor

DOI: 10.5958/0975-4377.2016.00018.5 Access: Open Access Read More

Formulation and in vivo evaluation of oro-dispersible tablets of ayurvedic powders Sitopaladi and Talisadi

Author(s): Deepak Khobragade, Sunil Kumar, Arun Kotha, Richa Gupta, K. Ravalika

DOI: 10.5958/0975-4377.2016.00024.0 Access: Open Access Read More

A Review on Biocompatible Hydrogel: Formulation Aspect and Evaluation

Author(s): Shubham Tripathi, Somnath Patel, Ritesh Patel, Shraddha,Pushpendra, Sachin,Neetish, Mahendra, Kuldeep, Prashant, Rajesh Patel, Girish, Nitin, Tomanlal, Amrita Thakur, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00019.8 Access: Open Access Read More

Formulation aspects behind the Development of a Stable Biphasic Liquid Dosage Form with Special Reference to Microemulsion: A Review

Author(s): Amrita Thakur, Nisha Nair, Mukta Agrawal, Yashi Thakur, Juhi Thakur,TemanNirmalkar,VedPrakashVerma,Vibhash Gupta,Vivek Singh Yadav,KalpanaMahilange, PoojaMahant, PritamYadav, Deepak Patel, Dinesh Khamari, JyotsanaMeshram, RakeshSahu, TarunGhatode, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0975-4377.2018.00018.6 Access: Open Access Read More

A Short Review on the Formulation of Transdermal Dermal Drug Delivery System (TDDS)

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9 Access: Open Access Read More

Fast Dissolving Tablets- A Review and Recent Advances in Manufacturing Technologies

Author(s): K Sonu Sharma, Rashmi Sharma, G Vidya Sagar

DOI: Access: Open Access Read More

Pharmacoepidemiology of Severe Systemic Infection and Need of Netilmicin Monotherapy or Combination Therapy: Systemic Review and Meta- Analysis

Author(s): Akhilesh Gupta, Swati Rawat, Prabhanshu Gupta

DOI: 10.5958/0975-4377.2017.00018.0 Access: Open Access Read More

Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Ketorolac Tromethamine and Olopatadine Hydrochloride in Pure and Pharmaceutical Formulation

Author(s): N. Sunitha, Y. Sujitha, B. Thangabalan, S. Manohar Babu

DOI: Access: Open Access Read More

Development of quality control parameters of an ayurvedic formulation: ‘Ashwagandhadi Churna’

Author(s): Mukesh Sharma, Nisha Amit, Kushagra Nagori, Sonam Soni, Shoyeb, Khushboo

DOI: Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377