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Research Journal of Pharmaceutical Dosage Forms and Technology
ISSN: 0975-4377(Online), 0975-234X(Print)
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Formulation and Evaluation of Chronomodulated Drug Delivery System
Mukund G Tawar
Satish V Shirolkar
Mahesh D Pawar
Nishant S Gandhi
Nilesh B Deore
Mukund G Tawar1*, Satish V Shirolkar1, Mahesh D Pawar2, Nishant S Gandhi1 and Nilesh B Deore1
1Pad. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018
2Microlabs Pvt. Ltd. Banglore.
A pulsatile drug delivery system which is time dependent, consist of an effervescent core surrounded by consecutive layers of swelling and rupturable layers were prepared and evaluated. The cores comprising of the active agent Terbutaline sulphate (ß2 blocker) was prepared by direct compression method using different ratios of Microcrystalline cellulose, Osmotic agent and effervescent agent. The outer rupturable layer consists of Eudragit RS/RL (1:1) which surround the inner swelling layer comprising of Hydroxy propyl methyl cellulose E5. The effect of various formulation and processing parameters were studied. The rupture and drug release studies were carried out using the USP paddle method at 50 rpm in 0.1 N HCl, and Phosphate buffer pH 6.8. The lag time of drug release was increased by increasing the rupturable layer and decreased by increasing the swelling layer level. The osmotic and the effervescent effect were involved in the drug release, as shown by the studies.
Nocturnal Asthma, Chronomudulated drug delivery, Terbutaline Sulphate, Swelling layer, Rupturable layer.
Mukund G Tawar, Satish V Shirolkar, Mahesh D Pawar, Nishant S Gandhi, Nilesh B Deore. Formulation and Evaluation of Chronomodulated Drug Delivery System. Research J. Pharma. Dosage Forms and Tech. 2010; 2(1):100-102.
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