Author(s): Y. Sirisha, Kurni Sai Kumar, Ramya Sri S

Email(s): ysirisha776@gmail.com

DOI: 10.52711/0975-4377.2023.00006   

Address: Y. Sirisha1*, Kurni Sai Kumar1, Ramya Sri S2
1Department of Pharmaceutics, Samskruti College of Pharmacy, Affiliated to JNTUH University, Hyderabad 501301, Telangana, India.
2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad – 500007, Telangana, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 1,     Year - 2023


ABSTRACT:
The aim of the present study was to develop Stavudine extended release tablets to maintain constant therapeutic levels of the drug for over 12 hrs. Xanthan gum, Sodium CMC and HPMC 15cps were used as polymers. All the formulations were passed various physicochemical evaluation parameters such as Bulk Density, Tapped Density, Carr’s Index, Hausners Ratio, Angle of Repose, Weight Variation, Hardness, Thickness, Friability and Drug Content. From the dissolution studies it was evident that the formulation F6 showed better and desired drug release pattern i.e., 99.12% in 12 hours. It contains the Sodium CMC as polymer. It followed Kars Mayer peppas release kinetics mechanism.


Cite this article:
Y. Sirisha, Kurni Sai Kumar, Ramya Sri S. Formulation Development and In vitro Characterisation of Stavudine Extended Release Matrix Tablets. Research Journal of Pharmaceutical Dosage Forms and Technology.2023; 15(1):31-5. doi: 10.52711/0975-4377.2023.00006

Cite(Electronic):
Y. Sirisha, Kurni Sai Kumar, Ramya Sri S. Formulation Development and In vitro Characterisation of Stavudine Extended Release Matrix Tablets. Research Journal of Pharmaceutical Dosage Forms and Technology.2023; 15(1):31-5. doi: 10.52711/0975-4377.2023.00006   Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-1-6


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